Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Toby J. Underwood"'
Autor:
Roger M. Howard, Thomas S. Moody, Andrew S. Rowan, Iain Miskelly, Toby J. Underwood, Yanan He, Bo Wang
Publikováno v:
Tetrahedron: Asymmetry. 24:1369-1381
Libraries of highly enantioenriched secondary alcohols in both enantiomeric forms were synthesised by enzymatic reduction of their parent ketones using selectAZyme™ carbonyl reductase (CRED) technology. Commercially available CREDs were able to red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364537aac54e7e7a7a304b7a96d5091f
https://doi.org/10.1016/j.tetasy.2013.09.015
https://doi.org/10.1016/j.tetasy.2013.09.015
Autor:
Toby J. Underwood, Richard C. D. Brown, Joseph T. Hill-Cousins, Peter R. Birkin, Derek Pletcher, Jekaterina Kuleshova
Publikováno v:
Electrochimica Acta. 69:197-202
A single channel microfluidic electrolysis cell being developed for application alongside other routine microfluidic operations in the laboratory has been applied to the methoxylation of N -formylpyrrolidine. It is shown that very high conversions (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db494a3478a219998a7bca4abda445a0
https://doi.org/10.1016/j.electacta.2012.02.093
https://doi.org/10.1016/j.electacta.2012.02.093
Autor:
Justin Stephen Bryans, Julie Newman, Patrick S. Johnson, Christelle Pasquinet, Torren M. Peakman, Toby J. Underwood, Simon Wheeler, Thomas Ryckmans, David M. Beal
Publikováno v:
Tetrahedron Letters. 52:5913-5917
This Letter describes the synthesis of a number of fused tricyclic and bicyclic triazolobenzodiazepines for the Vasopressin V1a antagonist programme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d407495746402d5d058007e210271f36
https://doi.org/10.1016/j.tetlet.2011.08.011
https://doi.org/10.1016/j.tetlet.2011.08.011
Autor:
James Edward John Mills, Thomas Ryckmans, Christelle Pasquinet, Patrick S. Johnson, Dave J. Rawson, Mark L. Lewis, Lee R. Roberts, Toby J. Underwood, Simon Wheeler, Helen J. Mason, Rachel Jane Russell, Julie Newman, David M. Beal, Dack Kevin Neil, Deborah Spark, Robin Ward, Alan Stobie, Neil Feeder, Anthony Harrison, Justin Stephen Bryans
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5684-5687
The V1a receptor has emerged as an attractive target for a range of indications including Raynaud's disease and dysmenorrhoea. As part of an effort to discover a new class of orally active V1a antagonist, we optimised a highly lipophilic, metabolical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298afc0cdd277e1e2be50694f3272c12
https://doi.org/10.1016/j.bmcl.2011.08.038
https://doi.org/10.1016/j.bmcl.2011.08.038
Autor:
Toby J. Underwood, Jekaterina Kuleshova, Richard C. D. Brown, Joseph T. Hill-Cousins, Peter R. Birkin, Derek Pletcher
Publikováno v:
Electrochimica Acta. 56:4322-4326
A single channel microfluidic electrolysis cell based on inexpensive materials and fabrication techniques is described. The cell is characterised using the electrochemistry of the Fe(CN) 6 3− /Fe(CN) 6 4− couple and its application in electrosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3acbbc87a25ceeefa81ac37a8d1bbc1
https://doi.org/10.1016/j.electacta.2011.01.036
https://doi.org/10.1016/j.electacta.2011.01.036
Autor:
Karl Richard Gibson, Yann C. Lecouturier, Paul A. Bradley, Malcolm C. Mackenny, Toby J. Underwood, Cedric Poinsard, Pieter D. de Koning, Inaki Morao
Publikováno v:
Synlett. 2010:873-876
This paper describes the large-scale synthesis of a progesterone receptor metabolite. The key step in this sequence was the regioselective pyrazole N-alkylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd9209195d15fad58263d91b8c874b8
https://doi.org/10.1055/s-0029-1219535
https://doi.org/10.1055/s-0029-1219535
Publikováno v:
Tetrahedron Letters. 50:7263-7267
A method for the safe and reliable iododeamination of aromatic and heteroaromatic amines under copper-free conditions is described and its scope is evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd93fa40a608d8897a044c5306110d0d
https://doi.org/10.1016/j.tetlet.2009.10.007
https://doi.org/10.1016/j.tetlet.2009.10.007
Autor:
Yann C. Lecouturier, Patrick S. Johnson, David J. McManus, Toby J. Underwood, Pieter D. de Koning, Aurelie A. Robin, Paul A. Bradley
Publikováno v:
Organic Process Research & Development. 13:848-853
The development and implementation of a scaleable process for the manufacture of the nonsteroidal progesterone receptor antagonist 8 is described. Key aspects of the synthesis include (i) a telescoped chlorination−etherification sequence to prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8253c85beb53be0a659af1112204f3d
https://doi.org/10.1021/op900110k
https://doi.org/10.1021/op900110k
Autor:
Carmen M. Baldino, Toby J. Underwood, Grace Bi, Wenwei Huang, Mary-Margaret O’Donnell, Andrew Simon Bell, Libing Yu, Jifeng Liu
Publikováno v:
Tetrahedron Letters. 45:8511-8514
Olsson’s three-component reaction of cyclopropylketones, aldehydes, and primary amines was investigated for application to parallel synthesis. Using an excess of Et2AlI at elevated temperatures, pyrrolidines 4 , the initial products reported by Ols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998ad5530ee32caf7970fa66d702f5b1
https://doi.org/10.1016/j.tetlet.2004.09.116
https://doi.org/10.1016/j.tetlet.2004.09.116
Autor:
Toby J. Underwood, Peter R. Birkin, Derek Pletcher, Jekaterina Kuleshova, Joseph T. Hill-Cousins, Robert A. Green, Stuart G. Leach, Richard C. D. Brown
Publikováno v:
ChemSusChem. 5(2)
A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described. The electrocatalytic system utilises a buf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7c94042151b7f477eba6229b6c8d8f
https://pubmed.ncbi.nlm.nih.gov/22337651
https://pubmed.ncbi.nlm.nih.gov/22337651