Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Toby G. Bush"'
Autor:
Piers C. Emson, Sarah L. Lambourne, Lynda A. Sellers, Lawrence Stephen Wilkinson, Toby G. Bush, Yoo-Hun Suh, Shewly K. Choudhury
Publikováno v:
Molecular and Cellular Biology. 25:278-293
Abnormal tau phosphorylation occurs in several neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Here, we compare mechanisms of tau phosphorylation in mous
Autor:
Toby G. Bush
Publikováno v:
BioEssays. 24:130-140
As a direct consequence of the sophisticated arrangement of its intrinsic neurons, the gastrointestinal tract is unique among peripheral organs, in its ability to mediate its own reflexes. Neurons of the enteric nervous system are intimately associat
Autor:
Lennart Mucke, Toby G. Bush, Michael V. Sofroniew, Natalie Blumauer, Lawrence Kruger, Martin H. Johnson
Publikováno v:
Brain Research. 835:91-95
Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated abl
Autor:
Narman Puvanachandra, Michael V. Sofroniew, Clive N. Svendsen, Anabella Polito, Thor Ostenfeld, Lennart Mucke, Toby G Bush, Martin H. Johnson, Catherine H. Horner
Publikováno v:
Neuron. 23(2):297-308
Reactive astrocytes adjacent to a forebrain stab injury were selectively ablated in adult mice expressing HSV-TK from the Gfap promoter by treatment with ganciclovir. Injured tissue that was depleted of GFAP-positive astrocytes exhibited (1) a prolon
Autor:
Elizabeth A. Campbell, Michael V. Sofroniew, Lennart Mucke, Tom C. Freeman, Tor C. Savidge, Toby G Bush, Hilary Cox, Martin H. Johnson
Publikováno v:
Cell. 93:189-201
To investigate the roles of astroglial cells, we targeted their ablation genetically. Transgenic mice were generated expressing herpes simplex virus thymidine kinase from the mouse glial fibrillary acidic protein (GFAP) promoter. In adult transgenic
Publikováno v:
Nature neuroscience. 7(11)
Establishing the cellular identity in vivo of adult multipotent neural progenitors is fundamental to understanding their biology. We used two transgenic strategies to determine the relative contribution of glial fibrillary acidic protein (GFAP)-expre
Publikováno v:
Autonomic neuroscience : basicclinical. 84(3)
We have studied migrating motor complexes (MMCs) in the isolated terminal ileum or colon (IMMCs and CMMCs respectively) of the C57BL/6 mouse. Periodic contractions occurred spontaneously in both preparations in the absence of intraluminal stimulation
Publikováno v:
Gastroenterology. 120:A186-A187
Publikováno v:
Gastroenterology. 118:A401
Publikováno v:
Europe PubMed Central
Alosetron (Lotronex) is a serotonin subtype 3 (5-HT3) receptor antagonist that alleviates symptoms of irritable bowel syndrome (IBS) in female patients. Alosetron may act centrally, involve the alteration of ascending pain sensation, or modulate peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78451775c569902cc05140ecf07aa50b
http://europepmc.org/abstract/med/11557518
http://europepmc.org/abstract/med/11557518