Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis

Autor: Finny Paterson, Iain Uings, John P. Iredale, Lisa Derr, George E. Dukes, Dawn Lyster, Andreas Tsoumanis, Lesley Briody, Natalie Z.M. Homer, Darren C. Robertson, Xiaozhong Zheng, Damian J. Mole, Alastair J. Hayes, Christos Skouras, Wayne L. Wright, O. James Garden, Toby B J Murray, Rowan W. Parks, Scott P. Webster, Heather Spence, John Liddle, Margaret Binnie

Publikováno v: Scientific Reports
Skouras, C, Zheng, X, Binnie, M, Homer, N Z M, Murray, T B J, Robertson, D, Briody, L, Paterson, F, Spence, H, Derr, L, Hayes, A J, Tsoumanis, A, Lyster, D, Parks, R W, Garden, O J, Iredale, J P, Uings, I J, Liddle, J, Wright, W L, Dukes, G, Webster, S P & Mole, D J 2016, ' Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis ', Scientific Reports, vol. 6, pp. 33951 . https://doi.org/10.1038/srep33951

Inhibition of kynurenine 3-monooxygenase (KMO) protects against multiple organ dysfunction (MODS) in experimental acute pancreatitis (AP). We aimed to precisely define the kynurenine pathway activation in relation to AP and AP-MODS in humans, by carr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfd3bce56fe1f72812882e67ba2a0f3
https://pubmed.ncbi.nlm.nih.gov/27669975