Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Toby A. Ferguson"'
Autor:
Matthew C. Kiernan, Steve Vucic, Toby A. Ferguson, Catherine Cummings, Kasper C D Roet, Merit Cudkowicz, Michael T Hotchkin, Angela Genge, Robert Glanzman
Publikováno v:
Muscle & Nerve. 64:532-537
Diagnostic criteria for amyotrophic lateral sclerosis (ALS) are complex, incorporating multiple levels of certainty from possible through to definite, and are thereby prone to error. Specifically, interrater variability was previously established to
Autor:
Timothy M, Miller, Merit E, Cudkowicz, Angela, Genge, Pamela J, Shaw, Gen, Sobue, Robert C, Bucelli, Adriano, Chiò, Philip, Van Damme, Albert C, Ludolph, Jonathan D, Glass, Jinsy A, Andrews, Suma, Babu, Michael, Benatar, Christopher J, McDermott, Thos, Cochrane, Sowmya, Chary, Sheena, Chew, Han, Zhu, Fan, Wu, Ivan, Nestorov, Danielle, Graham, Peng, Sun, Manjit, McNeill, Laura, Fanning, Toby A, Ferguson, Stephanie, Fradette, Cathy, Zhong
Publikováno v:
The New England journal of medicine. 387(12)
The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations inIn this phase 3 tri
Publikováno v:
Statistics in Medicine. 40:3035-3052
Amyotrophic lateral sclerosis (ALS) is a neurological disease that starts at a focal point and gradually spreads to other parts of the nervous system. One of the main clinical symptoms of ALS is muscle weakness. To study spreading patterns of muscle
Autor:
Marek Ma, Toby A. Ferguson, Kathleen M. Schoch, Jian Li, Yaping Qian, Frances S. Shofer, Kathryn E. Saatman, Robert W. Neumar
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 34-46 (2013)
In both the central nervous system (CNS) and peripheral nervous system (PNS), transected axons undergo Wallerian degeneration. Even though Augustus Waller first described this process after transection of axons in 1850, the molecular mechanisms may b
Externí odkaz:
https://doaj.org/article/bf91bd1d413b4af4bfd31e4befe8b270
Autor:
Robert C. Bucelli, Manjit McNeill, Shafeeq Ladha, Angela Genge, Stephanie Fradette, Ivan Nestorov, John Ravits, Philip Van Damme, Roger Lane, Christopher J McDermott, Jonathan Glass, Merit Cudkowicz, Laura Fanning, C. Frank Bennett, Heiko Runz, Ih Chang, Hani Houshyar, Toby A. Ferguson, Alfred Sandrock, Alan Pestronk, Danielle Graham, Timothy M. Miller, Randall G. Trudell, Nazem Atassi, Peter M. Andersen, François Salachas, Nicholas J. Maragakis, Albert L. Ludolph, Pamela J. Shaw, Lorne Zinman, Alexander McCampbell
Publikováno v:
New England Journal of Medicine. 383:109-119
Background Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administratio...
Autor:
Sonia Boodram, Amber Salter, Robert H. Baloh, Diane McKenna-Yasek, Matthew B. Harms, Thomas J. Esparza, Theodore Hyman, Robert H. Brown, Caroline Drain, Nicholas Wightman, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Leonard H. van den Berg, Toby A. Ferguson, Jan H. Veldink, Alexander Sherman, Michael A. van Es, Hong Yu, Catherine Douthwright, Jennifer Jockel-Balsarotti, Merit Cudkowicz, Alexander McCampbell, Margaret A. Owegi, Timothy M. Miller, Nazem Atassi, Amber Malcolm, Alexander J. Cammack, Bálint S de Vries, Jeffrey D. Rothstein
Publikováno v:
Neurology. 93:e1605-e1617
ObjectiveTo define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies.MethodsWe prospectively collected clinical and demographic data from 116
Publikováno v:
Biometrics. 75:1310-1320
This paper focuses on analysis of spatiotemporal binary data with absorbing states. The research was motivated by a clinical study on amyotrophic lateral sclerosis (ALS), a neurological disease marked by gradual loss of muscle strength over time in m
Autor:
Timothy, Miller, Merit, Cudkowicz, Pamela J, Shaw, Peter M, Andersen, Nazem, Atassi, Robert C, Bucelli, Angela, Genge, Jonathan, Glass, Shafeeq, Ladha, Albert L, Ludolph, Nicholas J, Maragakis, Christopher J, McDermott, Alan, Pestronk, John, Ravits, François, Salachas, Randall, Trudell, Philip, Van Damme, Lorne, Zinman, C Frank, Bennett, Roger, Lane, Alfred, Sandrock, Heiko, Runz, Danielle, Graham, Hani, Houshyar, Alexander, McCampbell, Ivan, Nestorov, Ih, Chang, Manjit, McNeill, Laura, Fanning, Stephanie, Fradette, Toby A, Ferguson
Publikováno v:
The New England journal of medicine. 383(2)
Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administration of tofersen is being studied for the treatment of amyotrophic lateral s
Autor:
Marinus J.C. Eijkemans, Leonard H. van den Berg, P. Nigel Leigh, Toby A. Ferguson, Ruben P A van Eijk, Kit C.B. Roes, Bas M. Middelkoop, Pamela J. Shaw, Ammar Al-Chalabi, Stavros Nikolakopoulos
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry, 90(12), 1331. BMJ Publishing Group
Journal of Neurology, Neurosurgery, and Psychiatry
Journal of Neurology, Neurosurgery, and Psychiatry, 90, 12, pp. 1331-1337
Journal of Neurology, Neurosurgery, and Psychiatry, 90, 1331-1337
Journal of Neurology, Neurosurgery, and Psychiatry
Journal of Neurology, Neurosurgery, and Psychiatry, 90, 12, pp. 1331-1337
Journal of Neurology, Neurosurgery, and Psychiatry, 90, 1331-1337
BackgroundFunding and resources for low prevalent neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) are limited, and optimising their use is vital for efficient drug development. In this study, we review the design assumptions f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7387d5532147e31785914711e9b6c3
https://dspace.library.uu.nl/handle/1874/390327
https://dspace.library.uu.nl/handle/1874/390327
Autor:
Maria O. Kovalchuk, Leonard H. van den Berg, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Hessel Franssen, Boudewijn T.H.M. Sleutjes, Toby A. Ferguson, Dimitrios Ziagkos
Publikováno v:
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 104(6), 1136-1145
Clinical Pharmacology and Therapeutics, 104(6), 1136-1145
Increased excitability of motor neurons in patients with amyotrophic lateral sclerosis (ALS) may be a relevant factor leading to motor neuron damage. This randomized, double-blind, three-way crossover, placebo-controlled study evaluated peripheral mo