Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Toby, Prout"'
Autor:
Robert Brown, Christina Yap, Johann De Bono, Malaka Ameratunga, Anna Minchom, Wei Yuan, Mateus Crespo, Bora Gurel, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Ana Ferreira, Claudia Bertan, Rita Pereira, Chloe Baker, Nina Tunariu, Suzanne Carreira, Udai Banerji, Juanita Lopez, Alison Turner, Wentin Chen, Abhijit Pal, Dionysis Papadatos-Pastos, Toby Prout, Maxime Chénard-Poirier, Andra Curcean, Nahal Masrour, Ricardo Morilla, Ben Jenkins, Anna Zachariou, Mona Parmar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/b9a84246b2264ed1b2c2acbbf2f19d79
Autor:
Susana Banerjee, Vasiliki Michalarea, Joo Ern Ang, Alvaro Ingles Garces, Andrea Biondo, Ionut-Gabriel Funingana, Martin Little, Ruth Ruddle, Florence Raynaud, Ruth Riisnaes, Bora Gurel, Sue Chua, Nina Tunariu, Joanna C. Porter, Toby Prout, Mona Parmar, Anna Zachariou, Alison Turner, Ben Jenkins, Stuart McIntosh, Ed Ainscow, Anna Minchom, Juanita Lopez, Johann de Bono, Robert Jones, Emma Hall, Natalie Cook, Bristi Basu, Udai Banerji
Publikováno v:
Clinical Cancer Research. 28:4634-4641
Purpose: CT900 is a novel small molecule thymidylate synthase inhibitor that binds to α-folate receptor (α-FR) and thus is selectively taken up by α-FR–overexpressing tumors. Patients and Methods: A 3+3 dose escalation design was used. During do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acc878b283c3c6e9cd5e46255c97453
https://doi.org/10.1158/1078-0432.ccr-22-1268
https://doi.org/10.1158/1078-0432.ccr-22-1268
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
Escalation phase dose levels and final recruitment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbcf33f6c433c0a43b2c0b533ff6f99
https://doi.org/10.1158/2159-8290.22535459.v1
https://doi.org/10.1158/2159-8290.22535459.v1
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
RMH200 panel design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463cc86a1d265fa62da6f6887c6a661c
https://doi.org/10.1158/2159-8290.22535438.v1
https://doi.org/10.1158/2159-8290.22535438.v1
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
Cyclin-dependent kinase 4/6 (CDK4/6) and PI3K inhibitors synergize in PIK3CA-mutant ER-positive HER2-negative breast cancer models. We conducted a phase Ib trial investigating the safety and efficacy of doublet CDK4/6 inhibitor palbociclib plus selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2188840c665bdd2ddabfa9e80f44d33
https://doi.org/10.1158/2159-8290.c.6547859.v1
https://doi.org/10.1158/2159-8290.c.6547859.v1
Autor:
Udai Banerji, Bristi Basu, Natalie Cook, Emma Hall, Robert Jones, Johann de Bono, Juanita Lopez, Anna Minchom, Ed Ainscow, Stuart McIntosh, Ben Jenkins, Alison Turner, Anna Zachariou, Mona Parmar, Toby Prout, Joanna C. Porter, Nina Tunariu, Sue Chua, Bora Gurel, Ruth Riisnaes, Florence Raynaud, Ruth Ruddle, Martin Little, Ionut-Gabriel Funingana, Andrea Biondo, Alvaro Ingles Garces, Joo Ern Ang, Vasiliki Michalarea, Susana Banerjee
Supplementary Figure from A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2704c4994794b5ac32f8afd095444629
https://doi.org/10.1158/1078-0432.22489008
https://doi.org/10.1158/1078-0432.22489008
Autor:
Udai Banerji, Bristi Basu, Natalie Cook, Emma Hall, Robert Jones, Johann de Bono, Juanita Lopez, Anna Minchom, Ed Ainscow, Stuart McIntosh, Ben Jenkins, Alison Turner, Anna Zachariou, Mona Parmar, Toby Prout, Joanna C. Porter, Nina Tunariu, Sue Chua, Bora Gurel, Ruth Riisnaes, Florence Raynaud, Ruth Ruddle, Martin Little, Ionut-Gabriel Funingana, Andrea Biondo, Alvaro Ingles Garces, Joo Ern Ang, Vasiliki Michalarea, Susana Banerjee
Supplementary Table from A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0475121ba5d79aa5db6a42030c640f34
https://doi.org/10.1158/1078-0432.22488999
https://doi.org/10.1158/1078-0432.22488999
Autor:
Udai Banerji, Bristi Basu, Natalie Cook, Emma Hall, Robert Jones, Johann de Bono, Juanita Lopez, Anna Minchom, Ed Ainscow, Stuart McIntosh, Ben Jenkins, Alison Turner, Anna Zachariou, Mona Parmar, Toby Prout, Joanna C. Porter, Nina Tunariu, Sue Chua, Bora Gurel, Ruth Riisnaes, Florence Raynaud, Ruth Ruddle, Martin Little, Ionut-Gabriel Funingana, Andrea Biondo, Alvaro Ingles Garces, Joo Ern Ang, Vasiliki Michalarea, Susana Banerjee
Purpose:CT900 is a novel small molecule thymidylate synthase inhibitor that binds to α-folate receptor (α-FR) and thus is selectively taken up by α-FR–overexpressing tumors.Patients and Methods:A 3+3 dose escalation design was used. During dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2962569a9f2efd37fe6e40c644a7cac
https://doi.org/10.1158/1078-0432.c.6532860
https://doi.org/10.1158/1078-0432.c.6532860
Autor:
Crescens Tiu, Wing Hing Yau, Liam C. Welsh, Timothy L. Jones, Anna Zachariou, Toby Prout, Mona Parmar, Alison J. Turner, Robert W. Daly, Christina Yap, Mateus Crespo, Bora Gurel, Ruth M. Riisnaes, Shaun A. DeCordova, Karen E. Swales, Udai Banerji, Anna R. Minchom, Adam Sharp, Johann S. de Bono, Juanita S. Lopez
Publikováno v:
Cancer Research. 83:CT093-CT093
Background PTEN loss of function is frequent in GBM correlating with poor prognosis, impaired antitumor responses and reduced efficacy of Immune Checkpoint Inhibitors (ICI). Ipat is a potent, selective, small-molecule inhibitor of Akt. Ipat efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd95f501edf0b9e956c9cf513010a42
https://doi.org/10.1158/1538-7445.am2023-ct093
https://doi.org/10.1158/1538-7445.am2023-ct093
Autor:
Simon Rodney, Adam R. Stewart, Victoria Sanchez Perez, Cienne Morton, Lisa A. Pickard, Taleen Shakouri, Toby Prout, Mona Parmar, Alison J. Turner, Silvia Coma, Jonathan Pachter, Laura Finneran, Emma Hall, James Spicer, Anna Minchom, Udai Banerji
Publikováno v:
Cancer Research. 83:3461-3461
Background: KRAS mutations (mt) are found in ~30% of non-small cell lung cancers (NSCLC). Despite the approval and development of KRAS G12C and KRAS G12D inhibitors respectively, mechanisms of resistance to MAPK pathway inhibitors are emerging and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c093cf361855d1d29362c252ceb8dad
https://doi.org/10.1158/1538-7445.am2023-3461
https://doi.org/10.1158/1538-7445.am2023-3461