Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Tobin R. Sosnick"'
An adaptive biomolecular condensation response is conserved across environmentally divergent species
Autor:
Samantha Keyport Kik, Dana Christopher, Hendrik Glauninger, Caitlin Wong Hickernell, Jared A. M. Bard, Kyle M. Lin, Allison H. Squires, Michael Ford, Tobin R. Sosnick, D. Allan Drummond
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and
Externí odkaz:
https://doaj.org/article/cba3406cd8d648c9bf1a14d49761dcdf
Autor:
Tobin R. Sosnick
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Externí odkaz:
https://doaj.org/article/e5fb109c4ccb4e2885de2582da07e4da
Autor:
Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback, Ezra Feldman, Jingxian Li, Tobin R. Sosnick, Minglei Zhao, Kelly R. Monk, Demet Araç
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and si
Externí odkaz:
https://doaj.org/article/e5359c615ebc4086814c00727386b7d8
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 1238-1243 (2019)
Externí odkaz:
https://doaj.org/article/0fbd8bc8c87f496fa9041f98545043ff
Discovering RNA-Protein Interactome by Using Chemical Context Profiling of the RNA-Protein Interface
Autor:
Marc Parisien, Xiaoyun Wang, George Perdrizet, II, Corissa Lamphear, Carol A. Fierke, Ketan C. Maheshwari, Michael J. Wilde, Tobin R. Sosnick, Tao Pan
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1703-1713 (2013)
RNA-protein (RNP) interactions generally are required for RNA function. At least 5% of human genes code for RNA-binding proteins. Whereas many approaches can identify the RNA partners for a specific protein, finding the protein partners for a specifi
Externí odkaz:
https://doaj.org/article/efd1fe3de01248769cbc26442ef46592
Publikováno v:
Journal of Chemical Theory and Computation. 18:2016-2032
Predicting protein binding is a core problem of computational biophysics. That this objective can be partly achieved with some amount of success using docking algorithms based on rigid protein models is remarkable, although going further requires all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bb6d95d14ac3810b99a9797079c954
https://doi.org/10.1021/acs.jctc.1c01255
https://doi.org/10.1021/acs.jctc.1c01255
Publikováno v:
bioRxiv
Prestin responds to transmembrane voltage fluctuations by changing its cross-sectional area, a process underlying the electromotility of outer hair cells and cochlear amplification. Prestin belongs to the SLC26 family of anion transporters yet is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249766d984c76aca724311cee473bd82
https://europepmc.org/articles/PMC10002659/
https://europepmc.org/articles/PMC10002659/
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2654
Volume 24
Issue 3
Pages: 2654
Single-molecule force spectroscopy methods, such as AFM and magnetic tweezers, have proved extremely beneficial in elucidating folding pathways for soluble and membrane proteins. To identify factors that determine the force rupture levels in force-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44cc97a5aa521cbec2228da7c00b4b3
Autor:
Shi-Jie Chen, Mubashir Hassan, Robert L. Jernigan, Kejue Jia, Daisuke Kihara, Andrzej Kloczkowski, Sergei Kotelnikov, Dima Kozakov, Jie Liang, Adam Liwo, Silvina Matysiak, Jarek Meller, Cristian Micheletti, Julie C. Mitchell, Sayantan Mondal, Ruth Nussinov, Kei-ichi Okazaki, Dzmitry Padhorny, Jeffrey Skolnick, Tobin R. Sosnick, George Stan, Ilya Vakser, Xiaoqin Zou, George D. Rose
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c481d1d5f097b8ed3738ea070541b2
https://pubmed.ncbi.nlm.nih.gov/36580595
https://pubmed.ncbi.nlm.nih.gov/36580595
Autor:
Ruofan Chen, Darren Kahan, Julia Shangguan, Joseph R. Sachleben, Joshua A. Riback, D. Allan Drummond, Tobin R. Sosnick
Eukaryotic cells form biomolecular condensates to sense and adapt to their environment1,2. Poly(A)-binding protein (Pab1), a canonical stress granule marker3,4, condenses upon heat shock or starvation, promoting adaptation5. The molecular basis of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5780b6267f1d7e342688f7a50514afe
https://doi.org/10.1101/2022.09.21.508844
https://doi.org/10.1101/2022.09.21.508844