Výsledky vyhledávání - "Tobias Wiedemann"

Akademický článek

Angpt2/Tie2 autostimulatory loop controls tumorigenesis

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-17 (2022)

Abstract Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non‐resectable neoplasms associated with frequent relapses and significant comorbidities. As the current therapies of NF‐PitNETs often fail, new therapeutic targe

Externí odkaz: https://doaj.org/article/c28ccb9ad81b4240bda2ef1d892b654e

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Akademický článek

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue,

Externí odkaz: https://doaj.org/article/4238107fca564fd486a026933c82d054

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Akademický článek

Helicobacter pylori induced gastric immunopathology is associated with distinct microbiota changes in the large intestines of long-term infected Mongolian gerbils.

Autor: Markus M Heimesaat, André Fischer, Rita Plickert, Tobias Wiedemann, Christoph Loddenkemper, Ulf B Göbel, Stefan Bereswill, Gabriele Rieder

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100362 (2014)

BACKGROUND: Gastrointestinal (GI) inflammation in mice and men are frequently accompanied by distinct changes of the GI microbiota composition at sites of inflammation. Helicobacter (H.) pylori infection results in gastric immunopathology accompanied

Externí odkaz: https://doaj.org/article/81295ed80cce4a8b9c8dd1d330564478

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Akademický článek

Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils.

Autor: Tobias Wiedemann, Eva Loell, Susanna Mueller, Mechthild Stoeckelhuber, Manfred Stolte, Rainer Haas, Gabriele Rieder

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4754 (2009)

Infection with Helicobacter pylori, carrying a functional cag type IV secretion system (cag-T4SS) to inject the Cytotoxin associated antigen (CagA) into gastric cells, is associated with an increased risk for severe gastric diseases in humans. Here w

Externí odkaz: https://doaj.org/article/cb6aeebad6d6483a92a92927e6583f03

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Data from Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas

Autor: Natalia S. Pellegata, Rickmer Braren, Federico Roncaroli, Ines Leinhäuser, Claudia Gross, Tobias Wiedemann, Misu Lee

Purpose: Novel therapeutic approaches are needed to improve the postoperative management of residual nonfunctioning pituitary adenomas (NFPA), given their high relapse rate. Here, we evaluated the antitumor efficacy of the dual PI3K/mTOR inhibitor NV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fe3c473316ec3faf4c55ba1d43a38b
https://doi.org/10.1158/1078-0432.c.6523961.v1

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WITHDRAWN: Adipocyte Deletion of ADAM17 Leads to Insulin Resistance in Association with Age and HFD in Mice

Autor: Maria Troullinaki, Valeria Lopez Salazar, Maria Rohm, Rhoda Anane Karikari, Lun Li, Moya Wu, Tobias Wiedemann, Anastasia Georgiadi, Rabih El-Merahbi, Alina Walth, Stephan Herzig, Manuel Gil Lozano

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35

Withdrawal: Valeria Lopez Salazar, Rhoda Anane Karikari, Lun Li, Rabih El-Merahbi, Maria Troullinaki, Moya Wu, Tobias Wiedemann, Alina Walth, Manuel Gil Lozano, Maria Rohm, Stephan Herzig, Anastasia Georgiadi. Adipocyte Deletion of ADAM17 Leads to In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf8916eb8b8a2e07dbbe8efef619cb5
https://pubmed.ncbi.nlm.nih.gov/34318951

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Gender-Specific Efficacy Revealed by Head-to-Head Comparison of Pasireotide and Octreotide in a Representative In Vivo Model of Nonfunctioning Pituitary Tumors

Autor: Johannes Notni, Isabel Valença, Donna P. Ankerst, Sebastian Gulde, Stefan Schulz, Mathias Schillmaier, Katja Steiger, Hsi-Yu Yen, Raúl M. Luque, Stephen Bäuerle, Amelie Lupp, Franz Schilling, Tobias Wiedemann, Herbert A. Schmid, Natalia S Pellegata

Publikováno v: Cancers
Cancers 13:3097 (2021)
Volume 13
Issue 12
Cancers, Vol 13, Iss 3097, p 3097 (2021)

Simple Summary No effective medical therapy exists for residual/recurrent nonfunctioning pituitary tumors (NFPTs). First-generation somatostatin analogs (SSAs) like octreotide targeting somatostatin receptor type 2 (SSTR2) are the mainstay therapy fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d51be59f934f391a616b3fc9064954c
http://europepmc.org/articles/PMC8235746

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Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Publikováno v: Nat. Commun. 12:1588 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Adipose tissue expansion, as seen in obesity, is often metabolically detrimental causing insulin resistance and the metabolic syndrome. However, white adipose tissue expansion at early ages is essential to establish a functional metabolism. To unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5656df324ae7869e70226bf68eaa0754
https://doi.org/10.1038/s41467-021-21826-9

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Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development

Autor: S. Ballke, Nicole Bechmann, Mirko Peitzsch, Tobias Wiedemann, Sebastian Gulde, Natalia S Pellegata, Hermine Mohr, Jaber Malekzadeh-Najafabadi, Vasilis Ntziachristos, Katja Steiger

Publikováno v: Cancers
Cancers 13:126 (2021)
Volume 13
Issue 1
Cancers, Vol 13, Iss 126, p 126 (2021)

Simple Summary Pheochromocytomas and paragangliomas (PPGLs) can be subdivided into at least three different subgroups associated with different clinical manifestations and depending on the risk to metastasize. A shortage in human tumor material, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12af82d48abe44e10adb19b459bbbe66
http://europepmc.org/articles/PMC7794757

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