Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tobias Welz"'
Autor:
Martin Kollmar, Tobias Welz, Aishwarya Ravi, Thomas Kaufmann, Noura Alzahofi, Klas Hatje, Asmahan Alghamdi, Jiyu Kim, Deborah A. Briggs, Annette Samol-Wolf, Olena Pylypenko, Alistair N. Hume, Pawel Burkhardt, Jan Faix, Eugen Kerkhoff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-21 (2024)
Abstract An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the origin of SPIRE actin nucleators. Mammalian SPIREs work with RAB GTPases, formin (FMN
Externí odkaz:
https://doaj.org/article/0ef371bb0f37464e940f4e2fa0201a73
Autor:
Noura Alzahofi, Tobias Welz, Christopher L. Robinson, Emma L. Page, Deborah A. Briggs, Amy K. Stainthorp, James Reekes, David A. Elbe, Felix Straub, Wouter W. Kallemeijn, Edward W. Tate, Philip S. Goff, Elena V. Sviderskaya, Marta Cantero, Lluis Montoliu, Francois Nedelec, Amanda K. Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N. Hume
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity
Externí odkaz:
https://doaj.org/article/4f3d5075c67d4d559d886e183af1f636
Autor:
Olena Pylypenko, Tobias Welz, Janine Tittel, Martin Kollmar, Florian Chardon, Gilles Malherbe, Sabine Weiss, Carina Ida Luise Michel, Annette Samol-Wolf, Andreas Till Grasskamp, Alistair Hume, Bruno Goud, Bruno Baron, Patrick England, Margaret A Titus, Petra Schwille, Thomas Weidemann, Anne Houdusse, Eugen Kerkhoff
Publikováno v:
eLife, Vol 5 (2016)
There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleato
Externí odkaz:
https://doaj.org/article/c2c1af684db44be18ca98b689ff18474
Autor:
Daniel Andritschke, Sabrina Dilling, Mario Emmenlauer, Tobias Welz, Fabian Schmich, Benjamin Misselwitz, Pauli Rämö, Klemens Rottner, Eugen Kerkhoff, Teiji Wada, Josef M Penninger, Niko Beerenwinkel, Peter Horvath, Christoph Dehio, Wolf-Dietrich Hardt
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161965 (2016)
Salmonella Typhimurium (S. Tm) is a leading cause of diarrhea. The disease is triggered by pathogen invasion into the gut epithelium. Invasion is attributed to the SPI-1 type 3 secretion system (T1). T1 injects effector proteins into epithelial cells
Externí odkaz:
https://doaj.org/article/5babca2e466f425b919d9eb22da76f5c
Autor:
Verena Leidgens, Corinna Seliger, Birgit Jachnik, Tobias Welz, Petra Leukel, Arabel Vollmann-Zwerenz, Ulrich Bogdahn, Marina Kreutz, Oliver M Grauer, Peter Hau
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140613 (2015)
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with anti-tumorigenic effects in different tumor entities. For glioma, research has generally focused on diclofenac; however data on other NSAIDs, such as ibuprofen, is limited. Ther
Externí odkaz:
https://doaj.org/article/6f67bea97fdd4be8afec4efcb9b5d982
Autor:
Philipp G Sand, Tobias Welz
Publikováno v:
Swiss Medical Weekly, Vol 144, Iss 0506 (2014)
Externí odkaz:
https://doaj.org/article/1c6882f4182f48cd86a605ee13df1728
Autor:
Tobias Welz, Eugen Kerkhoff
Publikováno v:
Journal of Cell Science. 136
Looking back at two decades of research on SPIRE actin nucleator proteins, the first decade was clearly dominated by the discovery of SPIRE proteins as founding members of the novel WH2-domain-based actin nucleators, which initiate actin filament ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05aaff599dda2bbb8d0ca072bc743b3c
https://doi.org/10.1242/jcs.260743
https://doi.org/10.1242/jcs.260743
Publikováno v:
PUB-Publications at Bielefeld University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ea8823ffb0d4e4b8e6ab98183d9727f
https://pub.uni-bielefeld.de/record/2968497
https://pub.uni-bielefeld.de/record/2968497
Advances in learning-based trajectory prediction are enabled by large-scale datasets. However, in-depth analysis of such datasets is limited. Moreover, the evaluation of prediction models is limited to metrics averaged over all samples in the dataset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336d6cb19a5793d3b057179f11083050
http://arxiv.org/abs/2206.05158
http://arxiv.org/abs/2206.05158
Autor:
Jessica Aprato, Magdalena Lippert, Jürgen Winkler, Alana Hoffmann, Stefanie Haase, María Nazareth González-Alvarado, Tobias Welz, Michael Wegner, Melissa Baumeister, Ralf A. Linker, Arif B. Ekici, Philipp Kirchner
Publikováno v:
GliaREFERENCES. 70(3)
Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0780539154e5b3cc5a98e5d7c7e35b
https://pubmed.ncbi.nlm.nih.gov/34787332
https://pubmed.ncbi.nlm.nih.gov/34787332