The temporal sequence of improved mitochondrial function on the dynamics of respiration, mobility, and cognition in aged Drosophila

Autor: Chris Hogg, Tobias W. Weinrich, Glen Jeffery

Publikováno v: Neurobiology of Aging. 70:140-147

Aging is associated with mitochondrial decline and reduced adenosine triphosphate (ATP) production leading to cellular dysfunction, but this is improved by long-wavelength light absorbed by cytochrome c oxidase, increasing cytochrome c oxidase activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742c71940d58880b7a06e3e9f1d4b0f9
https://doi.org/10.1016/j.neurobiolaging.2018.06.010

Fundamental differences in patterns of retinal ageing between primates and mice

Autor: Michael B. Powner, Nicholas W. Roberts, Tobias W. Weinrich, Harpreet Shinhmar, Jaimie Hoh Kam, Glen Jeffery, Asmaa Aboelnour

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Kam, J H, Weinrich, T W, Shinhmar, H, Powner, M B, Roberts, N W, Aboelnour, A & Jeffery, G 2019, ' Fundamental differences in patterns of retinal ageing between primates and mice ', Scientific Reports, vol. 9, 12574 (2019) . https://doi.org/10.1038/s41598-019-49121-0

Photoreceptors have high metabolic demands and age rapidly, undermining visual function. We base our understanding mainly on ageing mice where elevated inflammation, extracellular deposition, including that of amyloid beta, and rod and cone photorece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62bdfacf13adcad64b38990e9707d8d
https://doi.org/10.1038/s41598-019-49121-0

Mitochondrial absorption of short wavelength light drives primate blue retinal cones into glycolysis which may increase their pace of aging

Autor: Glen Jeffery, Tobias W. Weinrich, Jaimie Hoh Kam, Harpreet Sangha, R. A. E. Fosbury, Michael B. Powner

Publikováno v: Visual Neuroscience. 36

Photoreceptors have high energy demands and densely packed mitochondria through which light passes before phototransduction. Old world primates including humans have three cone photoreceptor types mediating color vision with short (S blue), medium (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5f20bf77b69364ca8cb0af6c887c2b
https://doi.org/10.1017/s0952523819000063

No evidence for loss of short-wavelength sensitive cone photoreceptors in normal ageing of the primate retina

Autor: Tobias W, Weinrich, Michael B, Powner, Aisling, Lynch, Ravi S, Jonnal, John S, Werner, Glen, Jeffery

Publikováno v: Scientific Reports

In old world primates including humans, cone photoreceptors are classified according to their maximal sensitivity at either short (S, blue), middle (M, green) or long (L, red) wavelengths. Colour discrimination studies show that the S-cone pathway is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81bd6c3de86c50a780639ce634b3a17e
https://pubmed.ncbi.nlm.nih.gov/28402329