Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tobias W. M. Keil"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 179:58-64
Nucleic acid drugs hold great promise for potential treatment of a variety of diseases. But efficient delivery is still the major challenge impeding translation. Nanoformulations based on polymers and lipids require preparation processes such as micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b96d874a8155bf00471034700dc9760
https://doi.org/10.1016/j.ejpb.2022.08.014
https://doi.org/10.1016/j.ejpb.2022.08.014
Autor:
Olivia M. Merkel, Tobias W. M. Keil
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
Eur J Pharm Biopharm
Eur J Pharm Biopharm
With the approval of the first siRNA-based drugs, non-viral siRNA delivery has gained special interest in industry and academia in the last two years. For non-viral delivery, positively charged lipid and polymer formulations play a central role in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe475e16860a4ceff061d74848d93cd
Publikováno v:
WIREs Nanomedicine and Nanobiotechnology. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a9c96c3da8f6cb686bfa406d09dd69
https://doi.org/10.1002/wnan.1666
https://doi.org/10.1002/wnan.1666
Publikováno v:
Wiley Interdiscip Rev Nanomed Nanobiotechnol
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Despite the large number of drugs available for the treatment of asthma, in 5-10% of the patients this disease is not well controlled. While most treatments palliate symptoms, those suffering from severe and uncontrolled asthma could benefit more fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b53dd442f8d50224f2c94efd614ef0
https://pubmed.ncbi.nlm.nih.gov/32267622
https://pubmed.ncbi.nlm.nih.gov/32267622
Autor:
Gabriella Costabile, Daniel P. Feldmann, Olivia M. Merkel, Qian Zhong, Sandro R. P. da Rocha, Tobias W. M. Keil
Publikováno v:
Eur J Pharm Biopharm
European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics
Localized aerosol delivery of gene therapies is a promising treatment of severe pulmonary diseases including lung cancer, cystic fibrosis, COPD and asthma. The administration of drugs by inhalation features multiple benefits including an enhanced pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b3065585411b358ea9d26496937b46
https://pubmed.ncbi.nlm.nih.gov/31445157
https://pubmed.ncbi.nlm.nih.gov/31445157
Autor:
Olivia M. Merkel, Tobias W. M. Keil
Publikováno v:
Therapeutic Delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7b03b21231780213714fa6dbbe08d9
Autor:
Aditi Mehta, Tobias W. M. Keil, Olivia M. Merkel, Domizia Baldassi, Wolfgang Friess, Christoph M Zimmermann, Friederike Adams
Publikováno v:
Advanced Therapeutics
Adv Ther (Weinh)
Adv Ther (Weinh)
To develop stable and inhalable dry powder formulations with long shelf life, we spray dried polyplexes consisting of siRNA and a polyethylenimine based block copolymer in presence of mannitol or trehalose. We investigated the effect of inlet (T-In)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994dfc98e2041240534f66695a427084
https://doi.org/10.1002/adtp.202100073
https://doi.org/10.1002/adtp.202100073
Autor:
Tobias W. M. Keil, Gregor K. Wenning, Lorenz Härtner, Nadia Stefanova, Eva Maria Fritz, Matthias Kreuzer, Thomas Fenzl
Publikováno v:
Frontiers in Behavioral Neuroscience
Multiple system atrophy (MSA) is a neurodegenerative movement disorder characterized by parkinsonian symptoms and cerebellar symptoms. Sleep disturbances also play a crucial role in MSA. One of the most convincing animal models in MSA research is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b78a74668a776972e8081154e1ed04
https://doi.org/10.3389/fnbeh.2016.00252
https://doi.org/10.3389/fnbeh.2016.00252