Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tobias Stopka"'
Publikováno v:
The Journal of Organic Chemistry. 88:3941-3944
Autor:
Jérémy Merad, Phillip S. Grant, Tobias Stopka, Juliette Sabbatani, Ricardo Meyrelles, Alexander Preinfalk, Ján Matyasovsky, Boris Maryasin, Leticia González, Nuno Maulide
Publikováno v:
Journal of the American Chemical Society. 144(27)
The reactivity of phosphorus and sulfur ylides toward carbonyl compounds constitutes a well-known dichotomy that is a common educational device in organic chemistry─the former gives olefins, while the latter gives epoxides. Herein, we report a ster
Autor:
Bogdan R. Brutiu, Jérémy Merad, Ján Matyašovský, Martina Drescher, Nuno Maulide, Alexandre Pinto, Tobias Stopka
Publikováno v:
Chemical Science
Isothiouronium salts are easily accessible and stable compounds. Herein, we report their use as versatile deoxasulfenylating agents enabling a stereoselective, thiol-free protocol for synthesis of thioethers from alcohols. The method is simple, scala
Publikováno v:
Synthesis. 51:194-202
In this article we describe the straightforward synthesis of polysubstituted pyrimidines by electrophilic activation of secondary amides in the presence of alkynes. An unusual mechanistic detour leading to pyridine derivatives as products is also pre
Publikováno v:
Angewandte Chemie. 129:13454-13458
Publikováno v:
Tetrahedron. 76:131460
α-Carbonyl cations were found to drive 1,2-carbon shift reactions with excellent selectivity. As opposed to traditional guidelines, this selectivity is based not on the electronic and steric properties of the migrating substituent but determined by
Publikováno v:
Organic Letters. 17:5080-5083
The reversible formation of covalent bonds enabled by the remarkably high Lewis acidity of our calcium-based catalyst system was used for the development of a new type of multicomponent reaction. Accordingly, a pharmacologically interesting bicyclic
Autor:
Tobias Stopka, Simon Janich, José Alemán, Ernst-Ulrich Würthwein, Constantin G. Daniliuc, Olga García Mancheño, Mercedes Zurro, Leyre Marzo
Publikováno v:
Angewandte Chemie International Edition. 54:5049-5053
Tricyclic dibenzoxepines and dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner-Meerwein-type rea
Autor:
Leyre Marzo, Ernst-Ulrich Würthwein, Constantin G. Daniliuc, Mercedes Zurro, Simon Janich, Olga García Mancheño, Tobias Stopka, José Alemán
Publikováno v:
Angewandte Chemie. 127:5137-5141
Tricyclische Dibenzoxepine und Dibenzazepine sind bedeutende Therapeutika fur die Pharmaindustrie und die akademische Forschung. Allerdings gestaltet sich ihre Synthese meist aufwandig und beinhaltet mehrere Stufen mit Wagner-Meerwein-Umlagerungen un
Publikováno v:
Angewandte Chemie (International ed. in English). 56(43)
The selective, metal-free generation of α-carbonyl cations from simple internal alkynes was accomplished by the addition of a sulfoxide to a densely substituted vinyl cation. The high reactivity of the α-carbonyl cations was found to efficiently in