Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Tobias Spielmann"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Plasmodium falciparum, the causative agent of malaria, poses a significant global health challenge, yet much of its biology remains elusive. A third of the genes in the P. falciparum genome lack annotations regarding their function, impeding
Externí odkaz:
https://doaj.org/article/98530d24615c438f967556237ba98df1
Autor:
Hannah M. Behrens, Sabine Schmidt, Isabelle G. Henshall, Patricia López-Barona, Domitille Peigney, Ricarda Sabitzki, Jürgen May, Oumou Maïga-Ascofaré, Tobias Spielmann
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Reduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in kelch13 (k13) but also in other genes, like ubp1. K13 and its compartment neighbors
Externí odkaz:
https://doaj.org/article/79e45d08ea3e46b7b85163877c8ff5a3
The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites.
Autor:
Sabine Schmidt, Jan Stephan Wichers-Misterek, Hannah Michaela Behrens, Jakob Birnbaum, Isabelle G Henshall, Jana Dröge, Ernst Jonscher, Sven Flemming, Carolina Castro-Peña, Paolo Mesén-Ramírez, Tobias Spielmann
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011814 (2023)
Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work indicated that K13 and other proteins co-localising with K13 (K13 compar
Externí odkaz:
https://doaj.org/article/44e7f5ab55c5407f99bc15ea3c9f69d5
Autor:
Jan Stephan Wichers, Paolo Mesén-Ramírez, Gwendolin Fuchs, Jing Yu-Strzelczyk, Jan Stäcker, Heidrun von Thien, Arne Alder, Isabelle Henshall, Benjamin Liffner, Georg Nagel, Christian Löw, Danny Wilson, Tobias Spielmann, Shiqiang Gao, Tim-Wolf Gilberger, Anna Bachmann, Jan Strauss
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients from the host, disp
Externí odkaz:
https://doaj.org/article/a379ad10a39b42889f322ee25fa90b4b
Autor:
Jan Stephan Wichers, Carolina van Gelder, Gwendolin Fuchs, Julia Mareike Ruge, Emma Pietsch, Josie L. Ferreira, Soraya Safavi, Heidrun von Thien, Paul-Christian Burda, Paolo Mesén-Ramirez, Tobias Spielmann, Jan Strauss, Tim-Wolf Gilberger, Anna Bachmann
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and blood plasma, requiring transport across mult
Externí odkaz:
https://doaj.org/article/38d7b0fafe1747a6b6d5b773d740b4e0
Autor:
Hugo Bisio, Rouaa Ben Chaabene, Ricarda Sabitzki, Bohumil Maco, Jean Baptiste Marq, Tim-Wolf Gilberger, Tobias Spielmann, Dominique Soldati-Favre
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Apicomplexans are obligate intracellular parasites harboring three sets of unique secretory organelles termed micronemes, rhoptries, and dense granules that are dedicated to the establishment of infection in the host cell. Apicomplexans rely
Externí odkaz:
https://doaj.org/article/83dfa7b17b2347c98d8759d52872bd43
Autor:
Paolo Mesén-Ramírez, Bärbel Bergmann, Thuy Tuyen Tran, Matthias Garten, Jan Stäcker, Isabel Naranjo-Prado, Katharina Höhn, Joshua Zimmerberg, Tobias Spielmann
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000473 (2019)
Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar membrane (PVM). This membrane fulfils critical roles for survival of the parasite in its intracellular niche such as in protein export and nutrient acquisitio
Externí odkaz:
https://doaj.org/article/2e356b474925443b84e89814ecf433bf
Autor:
Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000376 (2019)
Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline,
Externí odkaz:
https://doaj.org/article/19120ff55fa54ec1bc71582404843ed8
Autor:
Mariana De Niz, Ann-Katrin Ullrich, Arlett Heiber, Alexandra Blancke Soares, Christian Pick, Ruth Lyck, Derya Keller, Gesine Kaiser, Monica Prado, Sven Flemming, Hernando del Portillo, Chris J. Janse, Volker Heussler, Tobias Spielmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Proteins SBP1 and MAHRP1 of the human malaria parasite are required for sequestration of infected red blood cells in major organs. Here, De Niz et al. identify homologous proteins in the rodent parasite Plasmodium berghei, showing that they play simi
Externí odkaz:
https://doaj.org/article/ce5dde75c34e4b5ebcf04a7b660268c8
Autor:
Justin A. Boddey, Matthew T. O’Neill, Sash Lopaticki, Teresa G. Carvalho, Anthony N. Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J. Babon, Alan F. Cowman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via clea
Externí odkaz:
https://doaj.org/article/9c31a074ac774adfad666d242b4d3b61