Spartalizumab in combination with platinum-doublet chemotherapy with or without canakinumab in patients with PD-L1-unselected, metastatic NSCLC

Autor: Armando Santoro, Garrido Pilar, Daniel S.W. Tan, Jon Zugazagoitia, Frances A. Shepherd, Alessandra Bearz, Fabrice Barlesi, Tae Min Kim, Tobias R. Overbeck, Enriqueta Felip, Can Cai, Eddy Simantini, Tracey McCulloch, Eric S. Schaefer

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Abstract Background Despite promising outcomes of treatment with anti-programmed cell death (PD)-1/PD-ligand (L)1 agents in combination with platinum-doublet chemotherapy (PDC) in the first-line setting, a significant unmet medical need remains in pa

Externí odkaz: https://doaj.org/article/49d4a4474e494f5081ff231d7fc7b4f8

Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis

Autor: Achim Burrer, Stephan T. Egger, Tobias R. Spiller, Matthias Kirschner, Philipp Homan, Erich Seifritz, Stefan Vetter

Publikováno v: BMC Medicine, Vol 22, Iss 1, Pp 1-9 (2024)

Abstract Background Among patients diagnosed with schizophrenia, the presence of substance use poses an aggravating comorbidity, exerting a negative impact on the course of the disease, adherence to therapeutic regimens, treatment outcomes, duration

Externí odkaz: https://doaj.org/article/1a64970b2c9148febc0657158f4871bd

Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

Autor: Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson, Elizna Schoeman, Patrycja Skut, Tabitha Woodman, Adrien Eynaud, Lucy Hartnell, Byron Brook, Bing Cai, Mandy Lo, Reza Falsafi, Robert E. W. Hancock, Msandeni Chiume-Kayuni, Norman Lufesi, Constantin R. Popescu, Pascal M. Lavoie, Tobias Strunk, Andrew J. Currie, Tobias R. Kollmann, Nelly Amenyogbe, Amy H. Lee

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeat

Externí odkaz: https://doaj.org/article/b54f31f4736543a6a2fa9c599d17c04a

Impact of psychopathology on day-to-day living in patients with schizophrenia: A network analysis

Autor: Mona Redlich Bossy, Daniel R. Müller, Daryl W. Niedermoser, Achim Burrer, Tobias R. Spiller, Stefan Vetter, Erich Seifritz, Stephan T. Egger

Publikováno v: Comprehensive Psychiatry, Vol 133, Iss , Pp 152501- (2024)

Although the relationship between schizophrenia and disability is well established, the association between the symptoms of the disorder and functional domains remains unclear. The current study explored the nuances of the relationship between sympto

Externí odkaz: https://doaj.org/article/b82a1845534e48979f0e7cbaca341bd4

The Replication Database: Documenting the Replicability of Psychological Science

Autor: Lukas Röseler, Leonard Kaiser, Christopher Doetsch, Noah Klett, Christian Seida, Astrid Schütz, Balazs Aczel, Nadia Adelina, Valeria Agostini, Samuel Alarie, Nihan Albayrak-Aydemir, Alaa Aldoh, Ali H. Al-Hoorie, Flavio Azevedo, Bradley J. Baker, Charlotte Lilian Barth, Julia Beitner, Cameron Brick, Hilmar Brohmer, Subramanya Prasad Chandrashekar, Kai Li Chung, Jamie P. Cockcroft, Jamie Cummins, Veronica Diveica, Tsvetomira Dumbalska, Emir Efendic, Mahmoud Elsherif, Thomas Evans, Gilad Feldman, Adrien Fillon, Nico Förster, Joris Frese, Oliver Genschow, Vaitsa Giannouli, Biljana Gjoneska, Timo Gnambs, Amélie Gourdon-Kanhukamwe, Christopher J. Graham, Helena Hartmann, Clove Haviva, Alina Herderich, Leon P. Hilbert, Darías Holgado, Ian Hussey, Zlatomira G. Ilchovska, Tamara Kalandadze, Veli-Matti Karhulahti, Leon Kasseckert, Maren Klingelhöfer-Jens, Alina Koppold, Max Korbmacher, Louisa Kulke, Niclas Kuper, Annalise LaPlume, Gavin Leech, Feline Lohkamp, Nigel Mantou Lou, Dermot Lynott, Maximilian Maier, Maria Meier, Maria Montefinese, David Moreau, Kellen Mrkva, Monika Nemcova, Danna Oomen, Julian Packheiser, Shubham Pandey, Frank Papenmeier, Mariola Paruzel-Czachura, Yuri G. Pavlov, Zoran Pavlović, Charlotte R. Pennington, Merle-Marie Pittelkow, Willemijn Plomp, Paul E. Plonski, Ekaterina Pronizius, Andrew Adrian Pua, Katarzyna Pypno-Blajda, Manuel Rausch, Tobias R. Rebholz, Elena Richert, Jan Philipp Röer, Robert Ross, Kathleen Schmidt, Aleksandrina Skvortsova, Matthias F. J. Sperl, Alvin W. M. Tan, J. Lukas Thürmer, Aleksandra Tołopiło, Wolf Vanpaemel, Leigh Ann Vaughn, Steven Verheyen, Lukas Wallrich, Lucia Weber, Julia K. Wolska, Mirela Zaneva, Yikang Zhang

Publikováno v: Journal of Open Psychology Data, Vol 12, Iss 1, Pp 8-8 (2024)

In psychological science, replicability—repeating a study with a new sample achieving consistent results (Parsons et al., 2022)—is critical for affirming the validity of scientific findings. Despite its importance, replication efforts are few and

Externí odkaz: https://doaj.org/article/713c9840de3c483bbd141bbebbac950a