Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Tobias Obser"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Membrane-associated enzymes have been found to behave differently qualitatively and quantitatively in terms of activity. These findings were highly debated in the 1970s and many general correlations and reaction specific models have been pro
Externí odkaz:
https://doaj.org/article/39dd6a303592447687864c4198358719
Autor:
Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider, Volker Huck
Publikováno v:
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhes
Externí odkaz:
https://doaj.org/article/4724211813a942f88ee1330187df5e2a
Autor:
Anton Letzer, Katja Lehmann, Christian Mess, Gesa König, Tobias Obser, Sven Peine, Sonja Schneppenheim, Ulrich Budde, Stefan W Schneider, Reinhard Schneppenheim, Maria A Brehm
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232637 (2020)
ADAMTS13 regulates the hemostatic activity of von Willebrand factor (VWF). Determined by static assays, proteolytic activity
Externí odkaz:
https://doaj.org/article/53fef788d1eb457e873b2fe593502998
Autor:
Hilger Jagau, Ina-Kristin Behrens, Karen Lahme, Georgina Lorz, Reinhard W. Köster, Reinhard Schneppenheim, Tobias Obser, Maria A. Brehm, Gesa König, Thomas P. Kohler, Manfred Rohde, Ronald Frank, Werner Tegge, Marcus Fulde, Sven Hammerschmidt, Michael Steinert, Simone Bergmann
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Streptococcus pneumoniae is a major cause of community acquired pneumonia and septicaemia in humans. These diseases are frequently associated with thromboembolic cardiovascular complications. Pneumococci induce the exocytosis of endothelial Weibel-Pa
Externí odkaz:
https://doaj.org/article/2f4315b814da42b68805ff930cfd2697
Autor:
Sandra Posch, Camilo Aponte-Santamaría, Richard Schwarzl, Andreas Karner, Matthias Radtke, Frauke Gräter, Tobias Obser, Gesa König, Maria A. Brehm, Hermann J. Gruber, Roland R. Netz, Carsten Baldauf, Reinhard Schneppenheim, Robert Tampé, Peter Hinterdorfer
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 1080-1087 (2016)
We here give information for a deeper understanding of single molecule force spectroscopy (SMFS) data through the example of the blood protein von Willebrand factor (VWF). It is also shown, how fitting of rupture forces versus loading rate profiles i
Externí odkaz:
https://doaj.org/article/a6af907a1b04473db79970e4cbf3d20c
Autor:
Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A. Gilad, Thomas S. Kickler, Tobias Obser, Zaverio M. Ruggeri, Joseph Katz
Publikováno v:
International Journal of Biomedical Imaging, Vol 2017 (2017)
Tracking cells and proteins’ phenotypic changes in deep suspensions is critical for the direct imaging of blood-related phenomena in in vitro replica of cardiovascular systems and blood-handling devices. This paper introduces fluorescence imaging t
Externí odkaz:
https://doaj.org/article/bfd9fc4082b840e7be01e1bdacd5e5b1
Autor:
Sophia Gruber, Achim Löf, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser, Gesa König, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gräter, Maria A. Brehm, Martin Benoit, Jan Lipfert
Publikováno v:
Blood Advances. 6:5198-5209
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the trans-Golgi is still not fully understood. We use the single-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c7e187512275ac34597028501738a1
https://doi.org/10.1182/bloodadvances.2022006978
https://doi.org/10.1182/bloodadvances.2022006978
Autor:
Yuanyuan Wang, Xiaobo Liu, Tobias Obser, Alexander T. Bauer, Martin Heyes, Sarah Starzonek, Mina Zulal, Karena Opitz, Leonie Ott, Sabine Riethdorf, Tobias Lange, Klaus Pantel, Gerd Bendas, Stefan W. Schneider, Marion Kusche-Gullberg, Christian Gorzelanny
Publikováno v:
Matrix Biology
Heparan sulfate (HS), a highly negatively charged glycosaminoglycan, is ubiquitously present in all tissues and also exposed on the surface of mammalian cells. A plethora of molecules such as growth factors, cytokines or coagulation factors bear HS b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1222fdcd860133dca4d62e11f77ac79a
https://hdl.handle.net/11250/3057939
https://hdl.handle.net/11250/3057939
Autor:
Achim Loef, Reinhard Schneppenheim, Jan Lipfert, Gesa Koenig, Res Joehr, Adina Hausch, Maria A. Brehm, Sophia Gruber, Martin Benoit, Tobias Obser
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the (trans-)Golgi is still not fully understood. We use the single-molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d252ea8470c93fe053e0a8021ee18ae
https://doi.org/10.1101/2021.11.29.470312
https://doi.org/10.1101/2021.11.29.470312
Autor:
Achim Löf, Sophia Gruber, Martin Benoit, Jan Lipfert, Maria A. Brehm, Steffen M. Sedlak, Tobias Obser, Philipp U. Walker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The physiological function of proteins is often critically regulated by mechanical forces acting on them. Single-molecule manipulation techniques such as atomic force microscopy or optical tweezers have enabled unprecedented insights int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d37d29acbe2fe3c1e00e6eaba4c8a7b
https://doi.org/10.1073/pnas.1901794116
https://doi.org/10.1073/pnas.1901794116