Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tobias N. Hansen"'
Publikováno v:
JACS Au, Vol 4, Iss 5, Pp 1854-1862 (2024)
Externí odkaz:
https://doaj.org/article/7c34f47ddeab411d9d8c6102b3e57d53
Autor:
Julie E. Bolding, Pablo Martín-Gago, Nima Rajabi, Luke F. Gamon, Tobias N. Hansen, Michael Jonathan Davies, Christian Adam Olsen
The sirtuin enzymes are a family of lysine deacylases that regulate gene transcription and metabolism. Sirtuin 5 (SIRT5) hydrolyzes malonyl, succinyl, and glutaryl epsilon‐N‐carboxyacyllysine posttranslational modifications and has recently emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028176782758f24ed656f10fafd8abeb
https://doi.org/10.26434/chemrxiv-2022-zds91
https://doi.org/10.26434/chemrxiv-2022-zds91
Autor:
Nima Rajabi, Tobias N. Hansen, Alexander L. Nielsen, Huy T. Nguyen, Michael Bæk, Julie. E. Bolding, Oskar Ø. Bahlke, Sylvester E. G. Petersen, Christian R. O. Bartling, Kristian Strømgaard, Christian A. Olsen
Publikováno v:
Rajabi, N, Hansen, T N, Nielsen, A L, Nguyen, H T, Bæk, M, Bolding, J E, Bahlke, O, Petersen, S E G, Bartling, C R O, Strømgaard, K & Olsen, C A 2022, ' Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme** ', Angewandte Chemie-International Edition, vol. 61, no. 22, e202115805 . https://doi.org/10.1002/anie.202115805
Sirtuin 5 (SIRT5) is a protein lysine deacylase enzyme that regulates diverse biology by hydrolyzing ϵ-N-carboxyacyllysine posttranslational modifications in the cell. Inhibition of SIRT5 has been linked to potential treatment of several cancers but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956ebf1e24bd8815528df1bf86d2fcfe
https://curis.ku.dk/portal/da/publications/investigation-of-carboxylic-acid-isosteres-and-prodrugs-for-inhibition-of-the-human-sirt5-lysine-deacylase-enzyme(30614323-0e9e-4a4a-a1f4-3ac1d53aea94).html
https://curis.ku.dk/portal/da/publications/investigation-of-carboxylic-acid-isosteres-and-prodrugs-for-inhibition-of-the-human-sirt5-lysine-deacylase-enzyme(30614323-0e9e-4a4a-a1f4-3ac1d53aea94).html
Autor:
Tobias N. Hansen, Katrine Qvotrup, Hüsün Sheyma Kizilkaya, Florent Xavier Smit, Wijnand J.C. van der Velden, Thomas M. Frimurer, Mette M. Rosenkilde, Michael Lückmann, Amalie Nørskov, Alexander Hovard Sparre-Ulrich
Publikováno v:
Structure. 29:679-693.e6
Summary The glucose-dependent insulinotropic polypeptide (GIP) is a 42-residue metabolic hormone that is actively being targeted for its regulatory role of glycemia and energy balance. Limited structural data of its receptor has made ligand design te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1076ffb9356fcb342cd7e59b3e08f3e1
https://doi.org/10.1016/j.str.2021.04.001
https://doi.org/10.1016/j.str.2021.04.001