Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tobias Messemaker"'
Autor:
Maaike van Putten, Margriet Hulsker, Vishna Devi Nadarajah, Sandra H van Heiningen, Ella van Huizen, Maarten van Iterson, Peter Admiraal, Tobias Messemaker, Johan T den Dunnen, Peter A C 't Hoen, Annemieke Aartsma-Rus
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31937 (2012)
Duchenne muscular dystrophy (DMD) is a severe progressive muscular disorder caused by reading frame disrupting mutations in the DMD gene, preventing the synthesis of functional dystrophin. As dystrophin provides muscle fiber stability during contract
Externí odkaz:
https://doaj.org/article/fbe238b2ff9d4796865f9f03a0b85a9d
Autor:
Oliver Distler, Fiona Oakley, Shervin Assassi, Wouter T. van Haaften, Britta Maurer, Maurizio Calcagni, Mojca Frank-Bertoncelj, Jörg H W Distler, Gloria Salazar, Gabriela Kania, Janine Schniering, Fina A S Kurreeman, Robert Lafyatis, Jeska K de Vries-Bouwstra, Carol Feghali-Bostwick, Florian Renoux, Mara Stellato, E. Pachera, Tobias Messemaker, Gerard Dijkstra, Przemyslaw Blyszczuk, Adam Wunderlin, Gerhard Rogler
Publikováno v:
J Clin Invest
Journal of Clinical Investigation, 130(9), 4888-4905. AMER SOC CLINICAL INVESTIGATION INC
CLIN Journal, 130(9), 4888-4905. AMER SOC CLINICAL INVESTIGATION INC
Journal of Clinical Investigation, 130(9), 4888-4905. AMER SOC CLINICAL INVESTIGATION INC
CLIN Journal, 130(9), 4888-4905. AMER SOC CLINICAL INVESTIGATION INC
TGF-beta is a master regulator of fibrosis, driving the differentiation of fibroblasts into apoptosis-resistant myofibroblasts and sustaining the production of extracellular matrix (ECM) components. Here, we identified the nuclear long noncoding RNA
Autor:
René E. M. Toes, Fina A S Kurreeman, Mohey Eldin M. El Shikh, Frances Humby, Gianni Marone, S. Pagani, Amato de Paulis, Liliane Fossati-Jimack, Gareth W. Jones, Francesca Wanda Rossi, Felice Rivellese, Tobias Messemaker, Andreas Ramming, Simon Arnett Jones, Daniele Mauro, Alessandra Nerviani, Simon Rauber, Georg Schett, Costantino Pitzalis
Publikováno v:
Rivellese, F, Mauro, D, Nerviani, A, Pagani, S, Fossati-Jimack, L, Messemaker, T, Kurreeman, F, Toes, R, Rauber, S, Schett, G, Jones, G, Jones, S A, Rossi, F, Paulis, A D, Marone, G, Shikh, M E E, Humby, F & Pitzalis, C 2018, ' Mast cells in early rheumatoid arthritis associate with disease severity and support B-cell autoantibody production ', Annals of the Rheumatic Diseases, vol. 77, no. 12, pp. 1773-1781 . https://doi.org/10.1136/annrheumdis-2018-213418
ObjectivesMast cells (MCs) are involved in the pathogenesis of rheumatoid arthritis (RA). However, their contribution remains controversial. To establish their role in RA, we analysed their presence in the synovium of treatment-naïve patients with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3c02e9a14f5ac5b74cc489e2b39a7a
https://orca.cardiff.ac.uk/id/eprint/113384/1/ARD-18.pdf
https://orca.cardiff.ac.uk/id/eprint/113384/1/ARD-18.pdf
Autor:
Stefan Semrau, Rob C. Hoeben, Anke E. J. ât Jong, Selina M. van Leeuwen, Patrick R. van den Berg, Robert-Jan Palstra, Tobias Messemaker, Harald Mikkers
Publikováno v:
Scientific Reports, 8, 386
Scientific Reports, 8
Scientific Reports
Scientific Reports, 8:386. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, 8
Scientific Reports
Scientific Reports, 8:386. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells. This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 regulation is partially controlled by the Sox2 overlapping long non
Autor:
Varshna S. Goelela, Oliver Distler, A. Dorjee, Michael L. Whitfield, René E. M. Toes, Tobias Messemaker, Loubna Chadli, Jeroen de Groot, Harald Mikkers, Tom W J Huizinga, S.N. Andersen, Guoshuai Cai, Fina A S Kurreeman, Maaike Boonstra, Jamil Aarbiou, Jeska K de Vries-Bouwstra, Zhenghui Li
Publikováno v:
Poster Presentations.
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and multiple organs of which pathogenesis is poorly understood. Here we studied differentially expressed coding and non-coding genes in relation to SSc pat
Autor:
Fina A S Kurreeman, A.H.M. van der Helm-van Mil, Twj Huizinga, Tobias Messemaker, Harald Mikkers, Rem Toes
Publikováno v:
Genes and Immunity, 18(3), 191-196
Innate immune cells, such as monocytes, can adopt a long-lasting pro-inflammatory phenotype, a phenomenon called 'trained immunity'. In trained immunity, increased cytokine levels of genes, like interleukin (IL)-6 and tumor necrosis factor (TNF)-α,
Autor:
René E. M. Toes, A. Dorjee, Tom W J Huizinga, Tobias Messemaker, Joris J Schonkeren, Marieke Heijink, Jolien Suurmond, Fina A S Kurreeman, Kim L. L. Habets, M. Giera
Publikováno v:
Immune regulation.
Background Traditionally, immunological responses have been studied in-vitro whereby immune cells are subject to certain stimuli following which alterations in RNA and/or protein expression are measured. Recently, we have challenged this model by sho
Autor:
Hailiang Mei, Fina A S Kurreeman, René E. M. Toes, Varshna S. Goelela, Jeroen DeGroot, Guoshuai Cai, Jamil Aarbiou, S.N. Andersen, Loubna Chadli, Harmen H.M. Draisma, Jeska K de Vries-Bouwstra, Peter van ‘t Hof, Robert W. Simms, M. Boonstra, Oliver Distler, Tom W J Huizinga, Michael E. Johnson, Harald Mikkers, Michael L. Whitfield, Tobias Messemaker, Nicole M. Orzechowski, Annemarie L. Dorjée
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, 138(4), 826-835
Journal of Investigative Dermatology, 138(4), 826-835
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and multiple organs of which the pathogenesis is poorly understood. Here we studied differentially expressed coding and non-coding genes in relation to SSc pathogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8cf541a15a9aed2dc2eb13d732b297
http://hdl.handle.net/1887/115736
http://hdl.handle.net/1887/115736
Publikováno v:
Journal of Immunology, 195(1), 3-4
In their published article, Giles et al. ([1][1]) explored functional consequences of rs17611 in the TRAF1-C5 region and propose a mechanism for its contribution to rheumatoid arthritis (RA) pathology, as this SNP would associate with RA. To substant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c42ee7ede423015b5ff1b06a6c27713
https://hdl.handle.net/1887/101525
https://hdl.handle.net/1887/101525
Publikováno v:
Journal of Autoimmunity
Journal of Autoimmunity, 64, 74-81
Journal of Autoimmunity, 64, 74-81
The last decade has seen a dramatic technological revolution. The characterisation of the majority of the common variations in our genetic code in 2003 precipitated the discovery of the genetic risk factors predisposing to Rheumatoid Arthritis develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244498b7d0f48b8652a2f58225ce4352
https://hdl.handle.net/1887/114799
https://hdl.handle.net/1887/114799