Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tobias M. Postma"'
Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides
Autor:
Rob M. J. Liskamp, Carol-Anne Smith, Mathis O. Riehle, Mohammed Hezwani, Tobias M. Postma, Susan Gannon, Alin Pirvan, Ezequiel Silva Nigenda
Publikováno v:
MedChemComm. 9:982-987
A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides. The required building blocks were conveniently accessible from cysteine and could be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0979da7f452d27545a811c142c6816cf
https://doi.org/10.1039/c8md00113h
https://doi.org/10.1039/c8md00113h
Autor:
Tobias M. Postma, Fernando Albericio
Publikováno v:
European Journal of Organic Chemistry. 2014:3519-3530
Disulfide bonds play an important role in both proteins and peptides. They cause conformational constraints and increase the stability of such molecules. In nature, disulfide bonds are very common in animal and plant peptide toxins. These disulfide-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dff3c2ab2b6397d1102744cfc735ffd
https://doi.org/10.1002/ejoc.201402149
https://doi.org/10.1002/ejoc.201402149
Autor:
Tobias M. Postma, Fernando Albericio
Publikováno v:
ACS Combinatorial Science
A novel immobilized N-chlorosuccinimide resin was developed for peptide disulfide bond formation in combinatorial libraries. The resin is prepared in a simple two-step process from commercial starting materials. Disulfide formation is initiated by ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74289bfa58c29b4345b0b691b21be4f2
http://europepmc.org/articles/PMC3987461
http://europepmc.org/articles/PMC3987461
Autor:
Warren R. J. D. Galloway, Tobias M. Postma, David R. Spring, Jamie E. Stokes, G. Dan Pantoş, Fabien B. L. Cougnon
Publikováno v:
Synlett. 24:765-769
We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aa0f027a0c7dbf153e3af5585bc3245
https://doi.org/10.1055/s-0032-1318407
https://doi.org/10.1055/s-0032-1318407
Autor:
Wim E. Hennink, Rob M. J. Liskamp, Dirk T. S. Rijkers, Maarten van Dijk, Tobias M. Postma, Cornelus F. van Nostrum
Publikováno v:
Polymer. 51:2479-2485
A series of monomers based on the methyl, ethyl, and isopropyl esters of Nα-(methacryloyl)-serine and -threonine were synthesized, and used in an AIBN-initiated radical polymerization reaction to yield polymers with an Mn ranging between 6.6 and 23.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914d10e4883c2be05baab2650f154d7f
https://doi.org/10.1016/j.polymer.2010.04.010
https://doi.org/10.1016/j.polymer.2010.04.010
Autor:
Tobias M. Postma, Fernando Albericio
Publikováno v:
ChemInform. 45
Disulfide bonds play an important role in both proteins and peptides. They cause conformational constraints and increase the stability of such molecules. In nature, disulfide bonds are very common in animal and plant peptide toxins. These disulfide-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f5f9a703c92fec7a965c07006edd53
https://doi.org/10.1002/chin.201447257
https://doi.org/10.1002/chin.201447257
Autor:
Tobias M. Postma, Fernando Albericio
Publikováno v:
Organic Letters
Contrary to other studies, here we describe cysteine (Cys) pseudoproline-containing peptides with short deprotection times in TFA. The deprotection times fell in the same range as other protecting groups commonly used in SPPS (e.g., 1–3 h). Moreove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ebcfeb8eed3f139763d0be7f1cb668
https://pubmed.ncbi.nlm.nih.gov/24617568
https://pubmed.ncbi.nlm.nih.gov/24617568
Autor:
Tobias M. Postma, Fernando Albericio
Publikováno v:
ResearcherID
N-Chlorosuccinimide is described as a widely applicable on-resin disulfide-forming reagent. Disulfide bond formation was completed within 15 min in DMF. This strategy was successfully used in the synthesis of oxytocin and a regioselective synthesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942fc0a02e6ba53e2fe8ac996c3a907c
https://pubmed.ncbi.nlm.nih.gov/23320397
https://pubmed.ncbi.nlm.nih.gov/23320397
Publikováno v:
Organic letters. 14(21)
Trimethoxyphenylthio (S-Tmp) is described as a novel cysteine protecting group in Fmoc solid phase peptide synthesis replacing the difficult to remove tert-butylthio. S-Tmp and dimethoxyphenylthio (S-Dmp) were successfully used for cysteine protectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefdc6d3e7d33cef33a68a83f216ed68
https://pubmed.ncbi.nlm.nih.gov/23075145
https://pubmed.ncbi.nlm.nih.gov/23075145
Autor:
Tobias M. Postma, Fernando Albericio
Publikováno v:
RSC Advances. 3:14277
A novel method has been developed for the efficient formation of peptide disulfide bonds under aqueous conditions using N-chlorosuccinimide. Complete disulfide bond formation is achieved in 15 min with solvent mixtures containing water and acetonitri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea46f07a3d874614d9ebecc255c58c43
https://doi.org/10.1039/c3ra43149e
https://doi.org/10.1039/c3ra43149e