Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Tobias M. Böckers"'
Autor:
Xing-Yu Lan, You-Yu Gu, Ming-Juan Li, Tian-Jia Song, Fu-Jun Zhai, Yong Zhang, Jiang-Shan Zhan, Tobias M. Böckers, Xiao-Nan Yue, Jia-Nan Wang, Shuo Yuan, Meng-Ying Jin, Yu-Fei Xie, Wan-Wen Dang, Hai-Heng Hong, Zi-Rui Guo, Xue-Wei Wang, Rong Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Maternal immune activation (MIA) is closely related to the onset of autism-like behaviors in offspring, but the mechanism remains unclear. Maternal behaviors can influence offspring’s development and behaviors, as indicated in both hu
Externí odkaz:
https://doaj.org/article/3996c3bc24dc4066b9c29e958d3108cf
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102061- (2023)
Summary: We describe here a time-efficient, in-house protocol for synaptosome isolation and enrichment of the post-synaptic density (PSD) from hiPSC-derived motor neurons. By using biochemical sub-cellular fractionation, the crude synaptosome is firs
Externí odkaz:
https://doaj.org/article/f95c0d02a39145f99e2f9d1697692254
Autor:
Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Jürgen Bockmann, Anita Ignatius, Tobias M. Böckers, Jan Tuckermann
Publikováno v:
JBMR Plus, Vol 7, Iss 2, Pp n/a-n/a (2023)
ABSTRACT Mutations of the postsynaptic scaffold protein Shank2 lead to autism spectrum disorders (ASD). These patients frequently suffer from higher fracture risk. Here, we investigated whether Shank2 directly regulates bone mass. We show that Shank2
Externí odkaz:
https://doaj.org/article/46146bcba9f2479d9d2e4235043799ce
Autor:
Wonphorn Kandhavivorn, Hannes Glaß, Thomas Herrmannsdörfer, Tobias M. Böckers, Marc Uhlarz, Jonas Gronemann, Richard H. W. Funk, Jens Pietzsch, Arun Pal, Andreas Hermann
Publikováno v:
Cells, Vol 12, Iss 11, p 1502 (2023)
Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease characterized by sustained loss of neuromuscular junctions, degenerating corticospinal motoneurons and rapidly progressing muscle paralysis. Motoneurons have unique features, ess
Externí odkaz:
https://doaj.org/article/fd435e2e4066492885790824c9aaa7b5
Autor:
David Bayer, Stefano Antonucci, Hans-Peter Müller, Rami Saad, Luc Dupuis, Volker Rasche, Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek, Francesco Roselli
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-17 (2021)
Abstract Background Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS, but the exact exten
Externí odkaz:
https://doaj.org/article/a6593394dc8947b5b66f4a710304a553
Autor:
Yu-Chuan Dai, Hong-Feng Zhang, Michael Schön, Tobias M. Böckers, Song-Ping Han, Ji-Sheng Han, Rong Zhang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Autism spectrum disorder (ASD) is characterized by impaired social communication and repetitive/stereotyped behaviors. The neuropeptide oxytocin (OXT) plays a critical role in regulating social behaviors in the central nervous system, as indicated in
Externí odkaz:
https://doaj.org/article/142a0f1892964c06b5bd0b0d5479fc75
Autor:
Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Jürgen Bockmann, Anita Ignatius, Tobias M. Böckers, Jan Tuckermann
Publikováno v:
JBMR Plus. 7
Autor:
Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek, David Bayer, Luc Dupuis, Hans-Peter Müller, Stefano Antonucci, Volker Rasche, Rami Saad, Francesco Roselli
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-17 (2021)
Translational Neurodegeneration
Translational Neurodegeneration, [London] : BioMed Central, 2012-, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational Neurodegeneration, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational neurodegeneration 10(1), 17 (2021). doi:10.1186/s40035-021-00241-6
Translational Neurodegeneration
Translational Neurodegeneration, [London] : BioMed Central, 2012-, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational Neurodegeneration, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational neurodegeneration 10(1), 17 (2021). doi:10.1186/s40035-021-00241-6
Background Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS, but the exact extent of hypo
Autor:
Anika M. Helferich, Peter M. Andersen, Priyanka Tripathi, Vitaly Zimyanin, Sarah J Brockmann, Axel Freischmidt, Albert C. Ludolph, Hannes Glaß, Joachim Weis, Eleonora Aronica, Andreas Hermann, Peter J. Oefner, Karin M Danzer, Maria Demestre, Karlheinz Holzmann, Alfred Yamoah, Anand Goswami, Tobias M. Böckers, Jörg Reinders, Jochen H. Weishaupt, Katharina Limm, Ina Poser
Publikováno v:
Brain
Brain 144(4), 1214-1229 (2021). doi:10.1093/brain/awab018
Brain, 144(4), 1214-1229. Oxford University Press
Brain 144(4), 1214-1229 (2021). doi:10.1093/brain/awab018
Brain, 144(4), 1214-1229. Oxford University Press
Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in most ALS cases. Previously, we identified serum microRNAs downregulated in familial ALS, t
Autor:
Annika Risch, Tobias M. Böckers, Konrad Steinestel, Michael Schön, Ulrich Fassnacht, Nikola Golenhofen, Doreen Spiegelburg, Leon Schurr, Anja Böckers, Mira Seidel
Publikováno v:
Anatomical Sciences Education. 15:89-101
Scientific competences as defined in the German competency framework describes the ability to think independently and act scientifically, and forms a central component of medical education. This report describes its integration into anatomical teachi