Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Tobias Langenhan"'
Autor:
Tobias Langenhan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/43fd77e2fc0d415cbe47d1ea8c09b78e
Autor:
Fernando Vieira Contreras, Genevieve M. Auger, Lena Müller, Vincent Richter, Wolf Huetteroth, Florian Seufert, Peter W. Hildebrand, Nicole Scholz, Andreas S. Thum, Dmitrij Ljaschenko, Beatriz Blanco-Redondo, Tobias Langenhan
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113640- (2024)
Summary: Adhesion G-protein-coupled receptors (aGPCRs) form a large family of cell surface molecules with versatile tasks in organ development. Many aGPCRs still await their functional and pharmacological deorphanization. Here, we characterized the o
Externí odkaz:
https://doaj.org/article/6b0d071b2da64c7ca6015f86548323a1
Autor:
Tobias Langenhan
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113474- (2023)
Glioblastoma is a devastating brain malignancy that has remained intractable to modern cancer treatments. Ravn-Boess et al.1 have discovered that the adhesion G protein-coupled receptor CD97/ADGRE5 contributes to glioblastogenesis and makes for an ex
Externí odkaz:
https://doaj.org/article/e9b01978d3f14f9581c16abbe78633c7
Autor:
Marek B. Körner, Akhil Velluva, Linnaeus Bundalian, Maximilian Radtke, Chen-Ching Lin, Pia Zacher, Tobias Bartolomaeus, Anna S. Kirstein, Achmed Mrestani, Nicole Scholz, Konrad Platzer, Anne-Christin Teichmann, Julia Hentschel, Tobias Langenhan, Johannes R. Lemke, Antje Garten, Rami Abou Jamra, Diana Le Duc
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The 15q13.3 microdeletion has pleiotropic effects ranging from apparently healthy to severely affected individuals. The underlying basis of the variable phenotype remains elusive. We analyzed gene expression using blood from three individual
Externí odkaz:
https://doaj.org/article/f0c825a9e8ef41399622f3cfb955f5f9
Autor:
Jannik M. Buettner, Josiane K. Sime Longang, Florian Gerstner, Katharina S. Apel, Beatriz Blanco-Redondo, Leonie Sowoidnich, Eva Janzen, Tobias Langenhan, Brunhilde Wirth, Christian M. Simon
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103376- (2021)
Summary: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by reduced survival motor neuron (SMN) protein. Recently, SMN dysfunction has been linked to individual aspects of motor circuit pathology in a severe SMA mouse model. To de
Externí odkaz:
https://doaj.org/article/876d4240d23740fc9dadab41c2948ab4
Autor:
Sven Dannhäuser, Thomas J Lux, Chun Hu, Mareike Selcho, Jeremy T-C Chen, Nadine Ehmann, Divya Sachidanandan, Sarah Stopp, Dennis Pauls, Matthias Pawlak, Tobias Langenhan, Peter Soba, Heike L Rittner, Robert J Kittel
Publikováno v:
eLife, Vol 9 (2020)
Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes. Their frequent association with mechanosensitive functions suggests that processing of mechanical stimuli may be a common feature of this receptor family. Previously
Externí odkaz:
https://doaj.org/article/3621e5484bc74582b2f575daf6b07b1f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 9, Pp 3109-3118 (2018)
Precise modification of sequences in the Drosophila melanogaster genome underlies the powerful capacity to study molecular structure-function relationships in this model species. The emergence of CRISPR/Cas9 tools in combination with recombinase syst
Externí odkaz:
https://doaj.org/article/a439e974857a4bde845065cb4633532f
Autor:
Nicole Scholz, Jennifer Gehring, Chonglin Guan, Dmitrij Ljaschenko, Robin Fischer, Vetrivel Lakshmanan, Robert J. Kittel, Tobias Langenhan
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 866-874 (2015)
G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of
Externí odkaz:
https://doaj.org/article/6ec3e70356a24eb7bf4ff6a7477b6427
Autor:
Nicole Scholz, Chonglin Guan, Matthias Nieberler, Alexander Grotemeyer, Isabella Maiellaro, Shiqiang Gao, Sebastian Beck, Matthias Pawlak, Markus Sauer, Esther Asan, Sven Rothemund, Jana Winkler, Simone Prömel, Georg Nagel, Tobias Langenhan, Robert J Kittel
Publikováno v:
eLife, Vol 6 (2017)
Adhesion-type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, operate in organ development, brain function and govern immunological responses. Correspondingly, this receptor family is linked to a multitud
Externí odkaz:
https://doaj.org/article/e820c749773040feb7f732624cecd87d
Autor:
Simone Prömel, Marie Frickenhaus, Samantha Hughes, Lamia Mestek, David Staunton, Alison Woollard, Ioannis Vakonakis, Torsten Schöneberg, Ralf Schnabel, Andreas P. Russ, Tobias Langenhan
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 321-331 (2012)
Adhesion class G protein-coupled receptors (aGPCR) form the second largest group of seven-transmembrane-spanning (7TM) receptors whose molecular layout and function differ from canonical 7TM receptors. Despite their essential roles in immunity, tumor
Externí odkaz:
https://doaj.org/article/d46d010d9fbc404a8102cca8d868f516