Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tobias Langenberg"'
Autor:
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L. Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Publikováno v:
Cells, Vol 12, Iss 6, p 960 (2023)
In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that induction of a heat shock-related stress response mediated by Foldlin, a small-molecule to
Externí odkaz:
https://doaj.org/article/37999acd49cb4597b94c46b713bf272c
Autor:
Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Mutations in aggregation prone regions of recombinant proteins often improve their solubility, although they might cause negative effects on their structure and function. Here, the authors identify proteins hot spots that can be exploited to optimize
Externí odkaz:
https://doaj.org/article/83b3c708399847f480f311a4edf53932
Autor:
Annelii Ny, Wouter Vandevelde, Philipp Hohensinner, Manu Beerens, Ilse Geudens, Antonio Diez-Juan, Katleen Brepoels, Stéphane Plaisance, Paul A. Krieg, Tobias Langenberg, Stefan Vinckier, Aernout Luttun, Peter Carmeliet, Mieke Dewerchin
Publikováno v:
Biology Open, Vol 2, Iss 9, Pp 882-890 (2013)
Summary The importance of the blood- and lymph vessels in the transport of essential fluids, gases, macromolecules and cells in vertebrates warrants optimal insight into the regulatory mechanisms underlying their development. Mouse and zebrafish mode
Externí odkaz:
https://doaj.org/article/0dac48970f794fc39c5192857ccb5b71
Autor:
Evelyne Naus, Greet De Baets, Rob van der Kant, Frederic Rousseau, Jarne Pauwels, Keith L. Ligon, Joost Schymkowitz, Zeynep Kalender Atak, Stein Aerts, Veerle Haemels, F. De Smet, Mark Fiers, Kris Gevaert, Jie Xu, Tobias Langenberg, Joost Van Durme, Filip Claes, Youlia Lampi
Publikováno v:
SSRN Electronic Journal.
In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that the induction of a heat-shock response by Foldlin, a small-molecule tool compound, reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b36fc34be4642c80877f29149018aa
https://doi.org/10.2139/ssrn.3720306
https://doi.org/10.2139/ssrn.3720306
Autor:
Javier Delgado Blanco, Matty P. Weijenberg, Joost Schymkowitz, Mark S. Hipp, Shakti Ramkissoon, Frederik De Smet, Frédéric Amant, Piet A. van den Brandt, Tobias Langenberg, Keith L. Ligon, André D'Hoore, Filip Claes, Daphne Hompes, Evelyne Naus, Manon Van England, Lori A. Ramkissoon, Greet De Baets, Sandrina Lambrechts, Bert Houben, Xavier Sagaert, Mirian Saiz Rubio, Colinda C. J. M. Simons, Sarah Charbonneau, Stéphane Plaisance, Frederic Rousseau
Publikováno v:
The Journal of Pathology. 242:24-38
Although p53 protein aggregates have been observed in cancer cell lines and tumour tissue, their impact in cancer remains largely unknown. Here, we extensively screened for p53 aggregation phenotypes in tumour biopsies, and identified nuclear inclusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a6071d28cee5d8b2c507a710ffc26d
https://doi.org/10.1002/path.4872
https://doi.org/10.1002/path.4872
Publikováno v:
Nature biomedical engineering. 1(10)
© 2017 The Author(s). High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases. ispartof: Nature Biomedical Engineering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c930083f0bcb7f7b69ba1be3c52f95
https://pubmed.ncbi.nlm.nih.gov/31015591
https://pubmed.ncbi.nlm.nih.gov/31015591
Autor:
Greet De Baets, Marijke Brams, Joost Schymkowitz, Tobias Langenberg, Rodrigo Gallardo, Jacinte Beerten, Aleksandra Siekierska, Meine Ramakers, Joost Van Durme, Frederic Rousseau, Ashok Ganesan, Chris Ulens, Hannah Wilkinson, Frederik De Smet, Rob van der Kant
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature Communications
Nature Communications
Natural selection shapes protein solubility to physiological requirements and recombinant applications that require higher protein concentrations are often problematic. This raises the question whether the solubility of natural protein sequences can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513e7953bed9dcba7bfa9eeddb93dadf
https://doaj.org/article/83b3c708399847f480f311a4edf53932
https://doaj.org/article/83b3c708399847f480f311a4edf53932
Autor:
Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Frederic Rousseau, Tobias Langenberg, Hannah Wilkinson, Joost Van Durme, Rafaela Cassio, Joost Schymkowitz, Rob van der Kant, Chris Ulens, Nikolaos N. Louros, Ramon Duran-Romaña
Publikováno v:
Cell Reports
Summary The amyloid-like aggregation propensity present in most globular proteins is generally considered to be a secondary side effect resulting from the requirements of protein stability. Here, we demonstrate, however, that mutations in the globula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52de9236416a6beeee140c0ac5da9163
https://doi.org/10.1016/j.celrep.2020.03.076
https://doi.org/10.1016/j.celrep.2020.03.076
Autor:
Frederik De Smet, Mirian Saiz Rubio, Daphne Hompes, Evelyne Naus, Greet De Baets, Tobias Langenberg, Mark S Hipp, Bert Houben, Filip Claes, Sarah Charbonneau, Javier Delgado Blanco, Stephane Plaisance, Shakti Ramkissoon, Lori Ramkissoon, Colinda Simons, Piet van den Brandt, Matty Weijenberg, Manon Van England, Sandrina Lambrechts, Frederic Amant, André D'Hoore, Keith L Ligon, Xavier Sagaert, Joos
Publikováno v:
The Journal of Pathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::01a6071d28cee5d8b2c507a710ffc26d
Autor:
Peter Carmeliet, Aernout Luttun, Tobias Langenberg, Annelii Ny, Ilse Geudens, Philipp J. Hohensinner, Wouter Vandevelde, Stefan Vinckier, Paul A. Krieg, Mieke Dewerchin, Manu Beerens, Stéphane Plaisance, Antonio Diez-Juan, Katleen Brepoels
Publikováno v:
Biology Open
Biology Open, Vol 2, Iss 9, Pp 882-890 (2013)
Biology Open, Vol 2, Iss 9, Pp 882-890 (2013)
The importance of the blood- and lymph vessels in the transport of essential fluids, gases, macromolecules and cells in vertebrates warrants optimal insight into the regulatory mechanisms underlying their development. Mouse and zebrafish models of ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694cbd51f7cb8bdd606c846c56549f92
https://doi.org/10.1242/bio.20134739
https://doi.org/10.1242/bio.20134739