Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Tobias K, Karakach"'
Autor:
Brendon D. Parsons, Daniel Medina-Luna, Michal Scur, Marinella Pinelli, Gayani S. Gamage, Rebecca A. Chilvers, Yannick Hamon, Ibrahim H.I. Ahmed, Stéphane Savary, Andrew P. Makrigiannis, Nancy E. Braverman, Juan F. Rodriguez-Alcazar, Eicke Latz, Tobias K. Karakach, Francesca Di Cara
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113744- (2024)
Summary: Peroxisome biogenesis disorders (PBDs) represent a group of metabolic conditions that cause severe developmental defects. Peroxisomes are essential metabolic organelles, present in virtually every eukaryotic cell and mediating key processes
Externí odkaz:
https://doaj.org/article/a066126b3d614f75b0ca3c0d6ec4d610
Autor:
Thomas H. Mahood, Christopher D. Pascoe, Tobias K. Karakach, Aruni Jha, Sujata Basu, Peyman Ezzati, Victor Spicer, Neeloffer Mookherjee, Andrew J. Halayko
Publikováno v:
ACS Omega, Vol 6, Iss 2, Pp 1171-1189 (2021)
Externí odkaz:
https://doaj.org/article/74375d0e46a440cb93c0276699ab6f97
Autor:
Laure-Anne Teuwen, Laura P.M.H. De Rooij, Anne Cuypers, Katerina Rohlenova, Sébastien J. Dumas, Melissa García-Caballero, Elda Meta, Jacob Amersfoort, Federico Taverna, Lisa M. Becker, Nuphar Veiga, Anna Rita Cantelmo, Vincent Geldhof, Nadine V. Conchinha, Joanna Kalucka, Lucas Treps, Lena-Christin Conradi, Shawez Khan, Tobias K. Karakach, Stefaan Soenen, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Steven Van Laere, Mieke Dewerchin, Luc Dirix, Massimiliano Mazzone, Yonglun Luo, Peter Vermeulen, Peter Carmeliet
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109253- (2021)
Summary: Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing vi
Externí odkaz:
https://doaj.org/article/7dadc23d237d4576aa0fd412a6c1555b
Autor:
Neeloffer Mookherjee, Andrew J. Halayko, Thomas H. Mahood, Sujata Basu, Peyman Ezzati, Christopher D. Pascoe, Tobias K. Karakach, Aruni Jha, Victor Spicer
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 2, Pp 1171-1189 (2021)
ACS Omega, Vol 6, Iss 2, Pp 1171-1189 (2021)
To capture interplay between biological pathways, we analyzed the proteome from matched lung tissues and bronchoalveolar lavage fluid (BALF) of individual allergen-naïve and house dust mite (HDM)-challenged BALB/c mice, a model of allergic asthma. U
Serial RNA-seq studies of bulk samples are widespread and provide an opportunity for improved understanding of gene regulation during e.g., development or response to an incremental dose of a pharmacotherapeutic. In addition, the widely popular singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0043674085cbd519a74e8ec640443db4
https://doi.org/10.1101/2022.02.18.481000
https://doi.org/10.1101/2022.02.18.481000
Autor:
Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Giusy Di Conza, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-Maria Fendt
Publikováno v:
Cell Reports
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8+ T cells activated and differentiated in vitro in physiological medium to resolve these metabolic dynamics. We identify a differential
Autor:
Peter Carmeliet, M. Cristina Avramut, Valeria V. Orlova, Ton J. Rabelink, Wendy M.P.J. Sol, Bernard M. van den Berg, Christine L. Mummery, Gangqi Wang, Tobias K. Karakach, Cathelijne W. van den Berg, Gesa L. Tiemeier, Sébastien J. Dumas
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 803-816 (2019)
Stem Cell Reports
Stem Cell Reports, 13(5), 803-816. CELL PRESS
Stem Cell Reports
Stem Cell Reports, 13(5), 803-816. CELL PRESS
Summary Human induced pluripotent stem cells (hiPSCs) are used to study organogenesis and model disease as well as being developed for regenerative medicine. Endothelial cells are among the many cell types differentiated from hiPSCs, but their matura
Autor:
Juan, Fernández-García, Fabien, Franco, Sweta, Parik, Patricia, Altea-Manzano, Antonino Alejandro, Pane, Dorien, Broekaert, Joke, van Elsen, Ines, Vermeire, Tessa, Schalley, Mélanie, Planque, Thomas, van Brussel, Rogier, Schepers, Elodie, Modave, Tobias K, Karakach, Peter, Carmeliet, Diether, Lambrechts, Ping-Chih, Ho, Sarah-Maria, Fendt
Publikováno v:
Cell reports. 41(7)
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8
Autor:
Sarah-Maria Fendt, Peter Carmeliet, Rogier Schepers, Sweta Parik, Antonino Alejandro Pane, Juan Fernández-García, Fabien Franco, Tobias K. Karakach, Ping-Chih Ho, Dorien Broekaert, Joke Van Elsen, Ines Vermeire, Elodie Modave, Thomas Van Brussel, Diether Lambrechts
Cytotoxic T cells dynamically rewire their metabolism during the course of an immune response. While T-cell metabolism has been extensively studied at phenotypic endpoints of activation and differentiation, the underlying dynamics remain largely elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81551b208900057b3f8feb8cdf0f083
https://doi.org/10.1101/2021.07.27.453976
https://doi.org/10.1101/2021.07.27.453976
Autor:
Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort
Publikováno v:
Teuwen, L-A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L-C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, pp. 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec69ffb517f91c2c67be4491da86f10
https://lirias.kuleuven.be/handle/123456789/676947
https://lirias.kuleuven.be/handle/123456789/676947