Výsledky vyhledávání - "Tobias Janik"

Abstract 6227: Tumor cell heterogeneity may cause treatment failure of GPA33-targeted therapy in colorectal cancer

Autor: Teresa Börding, Tobias Janik, Markus Morkel, Christine Sers, David Horst

Publikováno v: Cancer Research. 83:6227-6227

Purpose: Glycoprotein A33 (GPA33) is a membrane protein almost exclusively expressed in intestinal epithelia and in more than 95% of colorectal cancers (CRCs). This renders GPA33 a promising antigen for targeted therapy, but trials did not meet pre-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e14a176dc64cdaa4fbdf0e25e268d33e
https://doi.org/10.1158/1538-7445.am2023-6227

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Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis

Autor: Laura Borsi, Katja Grün, Michael Kiehntopf, Alexander Berndt, Hartwig Kosmehl, Andreas Müller, Frank-D. Böhmer, Elisabeth Buchdunger, Andrea Uecker, Carola Leipner, Tobias Janik

Publikováno v: Cardiovascular Research. 79:118-126

Aims Coxsackievirus B3 (CVB3)-induced chronic myocarditis in mice is accompanied by severe fibrosis and by sustained elevation of platelet-derived growth factor (PDGF)-A, -B, and -C levels in the cardiac tissue. To test if PDGF stimulation of residen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035b718a77df13b09005c35bbf1424cc
https://doi.org/10.1093/cvr/cvn063

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Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1

Autor: Diana Herbert, Tobias Janik, Jan C. Simon, Matthias Busch, Anja Saalbach, Ulf Anderegg

Publikováno v: Experimental dermatology. 24(8)

The outcome of a cutaneous immune response is critically dependent upon the ability of dendritic cells (DC) to migrate from skin to the draining lymph nodes - a process that is influenced by the cutaneous tissue microenvironment. Here, the role of fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d514972fc2fb25fc133797b34bbd5455
https://pubmed.ncbi.nlm.nih.gov/25865800

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Interactions of T helper cells with fibroblast-like synoviocytes: up-regulation of matrix metalloproteinases by macrophage migration inhibitory factor from both Th1 and Th2 cells

Autor: Jürgen Bernhagen, Christina Pfirschke, Uta Schurigt, Rolf Bräuer, Marion Hückel, Tobias Janik, Ria Baumgrass, Ingo M. Irmler, Mieczyslaw Gajda

Publikováno v: Arthritis and rheumatism. 58(10)

Objective Interactions of immune cells, such as activated T helper cells, with fibroblast-like synoviocytes (FLS) play a crucial role in the joint destruction during human rheumatoid arthritis (RA). This study was undertaken to investigate the expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b70da158f44e29c6e455824aa66db25
https://pubmed.ncbi.nlm.nih.gov/18821693

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Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice

Autor: Tobias Janik, Peter K. Petrow, Mieczyslaw Gajda, Ricardo Bernhardt, Paul Saftig, Felix Beckmann, Rolf Bräuer, Klaus Matthias Hummel, Uta Schurigt, Renate Stöckigt, George Kollias, Peter Middel, Jochen Zwerina, Georg Schett, Susann Schüler, Bernd Wiederanders, Dieter Scharnweber

Publikováno v: Arthritis & rheumatism 58, 422-434 (2008). doi:10.1002/art.23224

Objective Cathepsin K is believed to have an eminent role in the pathologic resorption of bone. However, several studies have shown that other proteinases also participate in this process. In order to clarify the contribution of cathepsin K to the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdc746664357b610e657e650d2a35be
https://bib-pubdb1.desy.de/record/86957

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