Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Tobias J, Erb"'
Autor:
Hai He, Paul A. Gómez-Coronado, Jan Zarzycki, Sebastian Barthel, Jörg Kahnt, Peter Claus, Moritz Klein, Melanie Klose, Valérie de Crécy-Lagard, Daniel Schindler, Nicole Paczia, Timo Glatter, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Promiscuous enzymes often serve as the starting point for the evolution of novel functions. Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several times independently for different purposes during evolution
Externí odkaz:
https://doaj.org/article/5f1a2364ec8a465f91e3ac80a6c06931
Autor:
Helena Schulz-Mirbach, Jan Lukas Krüsemann, Theofania Andreadaki, Jana Natalie Nerlich, Eleni Mavrothalassiti, Simon Boecker, Philipp Schneider, Moritz Weresow, Omar Abdelwahab, Nicole Paczia, Beau Dronsella, Tobias J. Erb, Arren Bar-Even, Steffen Klamt, Steffen N. Lindner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Anaerobic microbial fermentations provide high product yields and are a cornerstone of industrial bio-based processes. However, the need for redox balancing limits the array of fermentable substrate-product combinations. To overcome this lim
Externí odkaz:
https://doaj.org/article/70455d7d634d43588ef2f556c5b5c224
Autor:
Youngchang Kim, Seung Hwan Lee, Priyanka Gade, Maren Nattermann, Natalia Maltseva, Michael Endres, Jing Chen, Philipp Wichmann, Yang Hu, Daniel G. Marchal, Yasuo Yoshikuni, Tobias J. Erb, Ramon Gonzalez, Karolina Michalska, Andrzej Joachimiak
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract 2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, cond
Externí odkaz:
https://doaj.org/article/6aa21acb3e0a48658c899fdf3ca1d48f
Autor:
Lennart Schada von Borzyskowski, Lucas Hermann, Katharina Kremer, Sebastian Barthel, Bianca Pommerenke, Timo Glatter, Nicole Paczia, Erhard Bremer, Tobias J. Erb
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT The hydroxyacid glycolate is a highly abundant carbon source in the environment. Glycolate is produced by unicellular photosynthetic organisms and excreted at petagram scales to the environment, where it serves as growth substrate for hetero
Externí odkaz:
https://doaj.org/article/86cb0367fb6d4e4992e9eb5c88e1bb4c
Autor:
Tong Wu, Paul A. Gómez-Coronado, Armin Kubis, Steffen N. Lindner, Philippe Marlière, Tobias J. Erb, Arren Bar-Even, Hai He
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract One-carbon (C1) substrates, such as methanol or formate, are attractive feedstocks for circular bioeconomy. These substrates are typically converted into formaldehyde, serving as the entry point into metabolism. Here, we design an erythrulos
Externí odkaz:
https://doaj.org/article/dc77682e3c67450e8410256ef49ef34f
Autor:
Kyoyoung Seo, Wei Shu, Christian Rückert-Reed, Patrick Gerlinger, Tobias J. Erb, Jörn Kalinowski, Christoph Wittmann
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-25 (2023)
Abstract Background Transforming waste and nonfood materials into bulk biofuels and chemicals represents a major stride in creating a sustainable bioindustry to optimize the use of resources while reducing environmental footprint. However, despite th
Externí odkaz:
https://doaj.org/article/f838683782cc46d4aa8b5f0777d5904a
Autor:
Amir Pandi, David Adam, Amir Zare, Van Tuan Trinh, Stefan L. Schaefer, Marie Burt, Björn Klabunde, Elizaveta Bobkova, Manish Kushwaha, Yeganeh Foroughijabbari, Peter Braun, Christoph Spahn, Christian Preußer, Elke Pogge von Strandmann, Helge B. Bode, Heiner von Buttlar, Wilhelm Bertrams, Anna Lena Jung, Frank Abendroth, Bernd Schmeck, Gerhard Hummer, Olalla Vázquez, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Bioactive peptides are key molecules in health and medicine. Deep learning holds a big promise for the discovery and design of bioactive peptides. Yet, suitable experimental approaches are required to validate candidates in high throughput a
Externí odkaz:
https://doaj.org/article/adbbacf7db9c45aca2f0981cf0f79344
Autor:
Maren Nattermann, Sebastian Wenk, Pascal Pfister, Hai He, Seung Hwan Lee, Witold Szymanski, Nils Guntermann, Fayin Zhu, Lennart Nickel, Charlotte Wallner, Jan Zarzycki, Nicole Paczia, Nina Gaißert, Giancarlo Franciò, Walter Leitner, Ramon Gonzalez, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced from CO2 by (electro-)chemical means and converted into value-added products by enzymatic cascades or engineered microbes. A key step in expanding syn
Externí odkaz:
https://doaj.org/article/e3ea1543e7bb47f085fc0b1f3974546b
Autor:
Amir Pandi, Christoph Diehl, Ali Yazdizadeh Kharrazi, Scott A. Scholz, Elizaveta Bobkova, Léon Faure, Maren Nattermann, David Adam, Nils Chapin, Yeganeh Foroughijabbari, Charles Moritz, Nicole Paczia, Niña Socorro Cortina, Jean-Loup Faulon, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Optimization of biological networks is often limited by wet lab labor and cost, and the lack of convenient computational tools. Here, aimed at democratization and standardization, the authors describe METIS, a modular and versatile active machine lea
Externí odkaz:
https://doaj.org/article/b8a33041772a47edb859903b3d19f8ed
Autor:
Helena Schulz-Mirbach, Alexandra Müller, Tong Wu, Pascal Pfister, Selçuk Aslan, Lennart Schada von Borzyskowski, Tobias J Erb, Arren Bar-Even, Steffen N Lindner
Publikováno v:
eLife, Vol 11 (2022)
Ammonium (NH4+) is essential to generate the nitrogenous building blocks of life. It gets assimilated via the canonical biosynthetic routes to glutamate and is further distributed throughout metabolism via a network of transaminases. To study the fle
Externí odkaz:
https://doaj.org/article/7a3f24498c7c496496cb5bc745ca4658