Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Tobias Heinen"'
Autor:
Jasper Panten, Tobias Heinen, Christina Ernst, Nils Eling, Rebecca E. Wagner, Maja Satorius, John C. Marioni, Oliver Stegle, Duncan T. Odom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here,
Externí odkaz:
https://doaj.org/article/0aabafdc3a6a47a1b3c45ad1b7b7f851
CellRegMap: a statistical framework for mapping context‐specific regulatory variants using scRNA‐seq
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 8, Pp 1-14 (2022)
Abstract Single‐cell RNA sequencing (scRNA‐seq) enables characterizing the cellular heterogeneity in human tissues. Recent technological advances have enabled the first population‐scale scRNA‐seq studies in hundreds of individuals, allowing t
Externí odkaz:
https://doaj.org/article/dd1f4450ca5c4d6f8d42bc6a9a7ce3e3
Autor:
Tobias Heinen, Stefano Secchia, James P. Reddington, Bingqing Zhao, Eileen E. M. Furlong, Oliver Stegle
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract While it is established that the functional impact of genetic variation can vary across cell types and states, capturing this diversity remains challenging. Current studies using bulk sequencing either ignore this heterogeneity or use sorted
Externí odkaz:
https://doaj.org/article/d6e21545247040abb5ec9a11c8b36ae5
Publikováno v:
Molecules, Vol 28, Iss 15, p 5910 (2023)
Sulphonamides have been one of the major pharmaceutical compound classes since their introduction in the 1930s. Co-crystallisation of sulphonamides with halogen bonding (XB) might lead to a new class of pharmaceutical-relevant co-crystals. We present
Externí odkaz:
https://doaj.org/article/32bbb4cdd6834484ba93c909c9a3dbb8
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Iridium oxide (IrOx-NP) and palladium nanoparticles (Pd-NP) were supported on a 2,6-dicyanopyridine-based covalent-triazine framework (DCP-CTF) by energy-saving and sustainable microwave-assisted thermal decomposition reactions in propylene carbonate
Externí odkaz:
https://doaj.org/article/0e06bedee7d34f2b89bbcadd54b34bcc
Autor:
Lars Rademacher, Thi Hai Yen Beglau, Özgür Karakas, Alex Spieß, Dennis Woschko, Tobias Heinen, Juri Barthel, Christoph Janiak
Publikováno v:
Electrochemistry Communications, Vol 136, Iss , Pp 107243- (2022)
Tin nanoparticles (Sn-NPs) embedded in Ketjen Black carbon (KB) were synthesized from anhydrous tin(II) chloride by reduction with sodium borohydride in the presence of different imidazolium based ionic liquids (ILs) or water and tested towards the h
Externí odkaz:
https://doaj.org/article/729ac47d75214ec2ae29b5678df9dc37
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Map2k7 (synonym Mkk7) is a conserved regulatory kinase gene and a central component of the JNK signaling cascade with key functions during cellular differentiation. It shows complex transcription patterns, and different transcript isoforms are known
Externí odkaz:
https://doaj.org/article/0b26a50be08a474cae4166c6d4266ba3
Autor:
Saskia Menzel, Tobias Heinen, Ishtvan Boldog, Thi Hai Yen Beglau, Shanghua Xing, Alex Spieß, Dennis Woschko, Christoph Janiak
Publikováno v:
CrystEngComm. 24:3675-3691
The hexagonal motifs dictated by the {Cu3} pyrazolate triangular units are joined together by the additional connectivity of the various alternating zinc (oxo)carboxylate units to form 2D/3D open structures (* relates the same example-structure).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb201ac8196e7eedd5b52fbb8138f9f6
https://doi.org/10.1039/d2ce00268j
https://doi.org/10.1039/d2ce00268j
Autor:
Dietrich Püschel, Julia Wiefermann, Simon Hédé, Tobias Heinen, Leo Pfeifer, Oliver Weingart, Markus Suta, Thomas J.J. Müller, Christoph Janiak
Publikováno v:
Journal of Materials Chemistry C.
The photoluminescence properties of the compounds 3,3'-(phenazine-5,10-diyl)dibenzonitrile (mBN) and 4',4'''-(phenazine-5,10-diyl)bis(([1,1'-biphenyl]-4-carbonitrile)) (BPN) are presented and compared to the known fluorophore 4,4'-(phenazine-5,10-diy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6077097ea3c1fe223fcd68ae7ca864
https://doi.org/10.1039/d3tc01228j
https://doi.org/10.1039/d3tc01228j
Publikováno v:
Zeitschrift für Kristallographie - Crystalline Materials. 237:109-116
5-Fluorouracil is a widely used anti-cancer drug which exhibits diverse polymorphic and co-crystalline behavior. Here we report two new solvent-free co-crystals of 5-fluorouracil with model co-formers nicotinamide and isonicotinamide, along with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0f1fd7c80b5ae65d80be272128b7b9c
https://doi.org/10.1515/zkri-2021-2052
https://doi.org/10.1515/zkri-2021-2052