Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

Autor: Dirk Fasshauer, Tobias H. Kloepper, Pawel Burkhardt, Christian Stegmann, Cordelia Imig, Markus C. Wahl, Frederique Varoqueaux, Benjamin H. Cooper

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 37, pp. 15264-15269
Proceedings of the National Academy of Sciences of the United States of America

SNARE protein-driven secretion of neurotransmitters from synaptic vesicles is at the center of neuronal communication. In the absence of the cytosolic protein Munc18-1, synaptic secretion comes to a halt. Although it is believed that Munc18-1 orchest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dced20bbb212ca6317870bd3c3bbbb
https://doi.org/10.1073/pnas.1106189108

SNAREing the Basis of Multicellularity: Consequences of Protein Family Expansion during Evolution

Autor: Dirk Fasshauer, Tobias H. Kloepper, C. Nickias Kienle

Publikováno v: Molecular Biology and Evolution. 25:2055-2068

Vesicle trafficking between intracellular compartments of eukaryotic cells is mediated by conserved protein machineries. In each trafficking step, fusion of the vesicle with the acceptor membrane is driven by a set of distinctive soluble N-ethylmalei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c26049faa219c1f92e2da82265f499a
https://doi.org/10.1093/molbev/msn151

Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis

Autor: Henning Urlaub, Mads Grønborg, Nathan J. Pavlos, Tobias H. Kloepper, John Jia En Chua, Janina Boyken, Dietmar Riedel, Silvio O. Rizzoli, Reinhard Jahn

Publikováno v: Journal of Neuroscience

Rab GTPases are molecular switches that orchestrate protein complexes before membrane fusion reactions. In synapses, Rab3 and Rab5 proteins have been implicated in the exo-endocytic cycling of synaptic vesicles (SVs), but an involvement of additional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a60cf818c780c45bcfd4369605c5a70
https://hdl.handle.net/11858/00-001M-0000-0018-08B5-111858/00-001M-0000-0018-08AE-411858/00-001M-0000-0012-D4F0-A11858/00-001M-0000-0018-08AC-8

Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi

Autor: Nickias, Kienle, Tobias H, Kloepper, Dirk, Fasshauer

Publikováno v: BMC Evolutionary Biology, Vol 9, Iss 1, p 19 (2009)
BMC Evolutionary Biology

Background In eukaryotic cells, directional transport between different compartments of the endomembrane system is mediated by vesicles that bud from a donor organelle and then fuse with an acceptor organelle. A family of integral membrane proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2abd7c83b66129b35b2f083a76b11261
http://www.biomedcentral.com/1471-2148/9/19

An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system

Autor: C. Nickias Kienle, Tobias H. Kloepper, Dirk Fasshauer

Publikováno v: Molecular Biology of the Cell

Proteins of the SNARE (soluble N-ethylmalemide–sensitive factor attachment protein receptor) family are essential for the fusion of transport vesicles with an acceptor membrane. Despite considerable sequence divergence, their mechanism of action is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655574c38cffdd1f783beee13c786647
https://pubmed.ncbi.nlm.nih.gov/17596510