Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Tobias Grob"'
Autor:
Simon L. April-Monn, Philipp Kirchner, Katharina Detjen, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous malignancy. We established patient-de
Externí odkaz:
https://doaj.org/article/4501b816ee864b8c8c471a5b031bef76
Autor:
Dennis Hoch, Manuela Rabaglio, Tobias Grob, Michael von Gunten, Jörg Beyer, Dilara Akhoundova
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 1280-1286 (2023)
Mismatch repair-deficient (dMMR) prostate cancer (PCa) is a rare (1–5%) but highly actionable molecular subgroup of PCa, vulnerable to immune checkpoint inhibitors. Our case of sporadic dMMR PCa due to large monoallelic co-deletion of EPCAM, MSH2,
Externí odkaz:
https://doaj.org/article/72b6acf28ae945e6910516cdc196dfa0
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 871-877 (2023)
In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of thes
Externí odkaz:
https://doaj.org/article/057b934bc8824803a930934fdce6200c
Autor:
Juliane Friemel, Irianna Torres, Elizabeth Brauneis, Tim Thörner, Alejandro A. Schäffer, E. Michael Gertz, Tobias Grob, Kati Seidl, Achim Weber, Thomas Ried, Kerstin Heselmeyer-Haddad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor, nonalcoholic fatty liver disease (NAFLD) are an unmet health issue due to widespread obesity. We assessed copy number changes of genes associated w
Externí odkaz:
https://doaj.org/article/10d6221a6a564d01ae9307dfc0dda781
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Supplementary Figure 1. Inhibitory effect of Cetuximab determined by western blot analysis of 12 HNSCC cell line lysates. Supplementary Figure 2. Time course of EGFR phosphorylation in HNSCC cell line UT-SCC 8. Supplementary Figure 3. Correlation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2861dab98115ba59a2863d22258b88
https://doi.org/10.1158/0008-5472.22416219.v1
https://doi.org/10.1158/0008-5472.22416219.v1
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Supplementary Table 1 Patient characteristics including EGFRK521 allele frequency. Supplementary Table 2 Characteristics and sequencing data of squamous cell carcinoma cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf07edc18e7ba91ca942179f80df7e1
https://doi.org/10.1158/0008-5472.22416216
https://doi.org/10.1158/0008-5472.22416216
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Supplemental Figures 1 to 6 from Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4bc16eeae53fa30a4b111b627183ce
https://doi.org/10.1158/0008-5472.22416222
https://doi.org/10.1158/0008-5472.22416222
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Head and neck squamous cell carcinomas (HNSCC) exhibiting resistance to the EGFR-targeting drug cetuximab poses a challenge to their effective clinical management. Here, we report a specific mechanism of resistance in this setting based upon the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25965099290cbcc9845191154ace7fe
https://doi.org/10.1158/0008-5472.c.6509496.v1
https://doi.org/10.1158/0008-5472.c.6509496.v1
Autor:
Stian Knappskog, Tobias Grob, Andreas Venizelos, Ursula Amstutz, Geir O. Hjortland, Inger M. Lothe, Christian Kersten, Eva Hofsli, Anna Sundlöv, Hege Elvebakken, Herish Garresori, Anne Couvelard, Johanna Svensson, Halfdan Sorbye, Aurel Perren
Publikováno v:
Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir O; Lothe, Inger M; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (2023). Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced Gastroenteropancreatic Neuroendocrine Carcinoma. JCO precision oncology, 7, e2200336. American Society of Clinical Oncology 10.1200/PO.22.00336
PURPOSE Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We assessed the applicability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1970b14db7dc3567d76b6a5ce9d869f
Autor:
Simon L. April-Monn, Katharina Detjen, Philipp Kirchner, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous epithelial malignancy. We established patient-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb14c55c77b4f97ea94822d0fdde77a
https://doi.org/10.1101/2022.12.10.519855
https://doi.org/10.1101/2022.12.10.519855