Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tobias Grabe"'
Autor:
Tobias Grabe, Kirujan Jeyakumar, Janina Niggenaber, Tom Schulz, Sandra Koska, Silke Kleinbölting, Michael Edmund Beck, Matthias P. Müller, Daniel Rauh
Publikováno v:
ACS Medicinal Chemistry Letters. 14:591-598
Autor:
Junjun Wu, Tobias Grabe, Jan-Luca Götz, Joshua Trapp, Aureo Serrano de Souza, Tobias Biermann, Alexander Wolf, Peer-Phillip Ley, Kun Duan, Roland Lachmayer, Wei Ren
Publikováno v:
Applied Physics B. 129
Autor:
Jonas Lategahn, Hannah L. Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Janina Niggenaber, Marina Keul, Fatma Parmaksiz, Matthias Baumann, Sascha Menninger, Eldar Zent, Ina Landel, Jörn Weisner, Kirujan Jeyakumar, Leonie Heyden, Nicole Russ, Fabienne Müller, Carina Lorenz, Johannes Brägelmann, Inga Spille, Tobias Grabe, Matthias P. Müller, Johannes M. Heuckmann, Bert M. Klebl, Peter Nussbaumer, Martin L. Sos, Daniel Rauh
Publikováno v:
Journal of Medicinal Chemistry. 65:6643-6655
Despite the clinical efficacy of epidermal growth factor receptor (EGFR) inhibitors, a subset of patients with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limited treatment options. Here, we present the dev
Autor:
Tobias Grabe, Tobias Biermann, Alexander Wolf, Jassim Al-Nuwaider, Henrik Krauss, Jannes August, Weijia Yu, Jannis Ben Heinz, Maximilian Bayerl, Ke Xu, Qiang Wang, Junjun Wu, Bernhard Roth, Wei Ren, Roland Lachmayer
Publikováno v:
Optics and Laser Technology 165 (2023)
Optics and Laser Technology
Optics and Laser Technology
While additive manufacturing (AM) enables the production of versatile optical components, the limited knowledge of manufacturing processes makes the development of accurate simulation tools and evaluation criteria challenging. In this work, we presen
Autor:
Julian Röttger, Tobias Grabe, Max Caspar Sundermeier, Fabian Kranert, Oktay Heizmann, Tobias Biermann, Arved Ziebehl, Peer-Phillip Ley, Alexander Wolf, Roland Lachmayer
Publikováno v:
Innovative Product Development by Additive Manufacturing 2021 ISBN: 9783031059179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b43bae6eff56164f97a70db8b3dc4bf8
https://doi.org/10.1007/978-3-031-05918-6_12
https://doi.org/10.1007/978-3-031-05918-6_12
Autor:
Shubhendu Palei, Jörn Weisner, Melina Vogt, Rajesh Gontla, Benjamin Buchmuller, Christiane Ehrt, Tobias Grabe, Silke Kleinbölting, Matthias Müller, Guido H. Clever, Daniel Rauh, Daniel Summerer
Ten-eleven translocation dioxygenases (TETs) are the erasers of 5-methylcytosine (mC), the central epigenetic regulator of mammalian DNA. TETs convert mC to three oxidized derivatives with unique physicochemical properties and inherent regulatory pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d120b97693d77b10687f4944c2e4be
Autor:
Daniel Rauh, Matthias P. Müller, Jonas Lategahn, Tobias Grabe, Janina Niggenaber, Leonie Heyden
Publikováno v:
ACS Med Chem Lett
[Image: see text] Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) and currently the gold-standard for the treatment of patients suffering from non-small cell lung cancer (NSCLC) harboring T790M-mutated epidermal growth factor recept
Autor:
Philip Klövekorn, Jonas Lategahn, Willem A. L. van Otterlo, Julia Hardick, Tobias Grabe, Daniel Rauh, Luke Hodson, Matthias P. Müller, Tonia Kirschner, Kirujan Jeyakumar, Matthias Baumann, Julia Ketzer, Sebastian Bauer, Susanne Terheyden, Janina Niggenaber, Christian Becker, Anke Unger, Hannah L. Tumbrink, Jörn Weisner, Marina Keul
Publikováno v:
Journal of Medicinal Chemistry. 63:11725-11755
Mutated or amplified Her2 serves as a driver of non-small cell lung cancer or mediates resistance toward the inhibition of its family member epidermal growth factor receptor with small-molecule inhibitors. To date, small-molecule inhibitors targeting
Publikováno v:
Generative Manufacturing of Optical, Thermal and Structural Components (GROTESK) ISBN: 9783030965006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67109807869b9b358fae81a23ed2d080
https://doi.org/10.1007/978-3-030-96501-3_3
https://doi.org/10.1007/978-3-030-96501-3_3
Autor:
Janina Niggenaber, Matthias Baumann, Sebastian Bauer, Heiko Muller, Tobias Grabe, Jan G. Hengstler, Marina Keul, Luke Hodson, Georgia Günther, Anke Unger, Bernhard Blank-Landeshammer, Daniel Rauh, Alena Heimsoeth, Hannah L. Tumbrink, Julia Ketzer, Christopher Golz, Matthias P. Müller, René P. Zahedi, Carsten Strohmann, Wolf Hiller, Julian Engel, Willem A. L. van Otterlo, Julia Hardick, Philip Klövekorn, Jonas Lategahn, Maren Flaßhoff, Laxmikanth Kollipara, Carsten Schultz-Fademrecht, Thomas Mühlenberg
Publikováno v:
Chemical science, 10:10789
Chemical Science
Chemical Science
We present inhibitors of drug resistant mutants of EGFR including T790M and C797S. In addition, we present the first X-ray crystal structures of covalent inhibitors in complex with C797S-mutated EGFR to gain insight into their binding mode.
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