Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Tobias Goschzik"'
Autor:
Steffen Albrecht, Barbara Miedzybrodzki, Laura Palma, Van Hung Nguyen, Roy W.R. Dudley, Torsten Pietsch, Tobias Goschzik, Nada Jabado, Catherine Goudie, William D. Foulkes
Publikováno v:
Free Neuropathology, Vol 3 (2022)
Cowden syndrome (CS) is an autosomal dominant hamartoma and tumor predisposition syndrome caused by heterozygous pathogenic germline variants in PTEN in most affected individuals. Major features include macrocrania, multiple facial tricholemmomas, ac
Externí odkaz:
https://doaj.org/article/a049d1d22d2d46be910ef5921046b451
Autor:
Jack Goddard, Jemma Castle, Emily Southworth, Anya Fletcher, Stephen Crosier, Idoia Martin-Guerrero, Miguel García-Ariza, Aurora Navajas, Julien Masliah-Planchon, Franck Bourdeaut, Christelle Dufour, Olivier Ayrault, Tobias Goschzik, Torsten Pietsch, Martin Sill, Stefan M. Pfister, Stefan Rutkowski, Stacey Richardson, Rebecca M. Hill, Daniel Williamson, Simon Bailey, Edward C. Schwalbe, Steven C. Clifford, Debbie Hicks
Publikováno v:
Acta Neuropathologica. 145:651-666
Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MBGrp4 molecular substructures have been identified (e.g. subgroups/cytogenetics/mutations), howev
Autor:
Svenja Tonn, Andrey Korshunov, Denise Obrecht, Martin Sill, Michael Spohn, Katja von Hoff, Till Milde, Torsten Pietsch, Tobias Goschzik, Brigitte Bison, Björn-Ole Juhnke, Nina Struve, Dominik Sturm, Felix Sahm, Michael Bockmayr, Carsten Friedrich, André O von Bueren, Nicolas U Gerber, Martin Benesch, David T W Jones, Marcel Kool, Annika K Wefers, Ulrich Schüller, Stefan M Pfister, Stefan Rutkowski, Martin Mynarek
Publikováno v:
Neuro-Oncology.
Background The prognostic impact of clinical risk factors and DNA methylation patterns in sonic hedgehog (SHH)-activated early childhood desmoplastic/nodular medulloblastoma (DMB) or medulloblastoma with extensive nodularity (MBEN) were evaluated to
Autor:
Tobias Goschzik, Mathias Yuan, Martin Mynarek, Elke Pfaff, Evelyn Dörner, David T. Jones, Stefan M. Pfister, Stefan Rutkowski, Torsten Pietsch
Publikováno v:
Cancer Research. 83:3561-3561
Introduction: Genome-wide methylation analyses recently revealed novel epigenetic pineoblastoma (PBL) subtypes, but so far few data are available on recurrent cytogenetic alterations due to the rarity of these neoplasms. Therefore, our aim was to she
Autor:
Pitt Niehusmann, Einar Stensvold, Henning Leske, Torsten Pietsch, Tobias Goschzik, Gerrit H. Gielen, Bernt Due‐Tønnessen, Radek Frič, Yngvar Nilssen, Petter Brandal
Publikováno v:
Pediatric bloodcancerREFERENCES. 69(9)
Background An unexplained regional difference in survival was observed in previous publications on outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS-PNET) in Norway. We aimed now to reevaluate an
Autor:
Lea L. Friker, Theophilos Tzaridis, Simon Jonas Enkirch, Christine Lüders, Elke Hattingen, Glen Kristiansen, Tobias Goschzik, Andreas Waha, Christiana Lütter, Johannes Weller, Ulrich Herrlinger, Torsten Pietsch, Marco Gessi, Brigitta Baumert, Gerrit H. Gielen
Gliosarcoma is a rare histopathological subtype of glioblastoma. Metastatic spreading is very unusual. In this report, we illustrate a case of gliosarcoma with extensive extracranial metastases with confirmation of histological and molecular concorda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc49fb3729b0a99fac01aa668776dfb5
https://doi.org/10.21203/rs.3.rs-1412200/v1
https://doi.org/10.21203/rs.3.rs-1412200/v1
Autor:
Tobias Goschzik, Martin Mynarek, Evelyn Doerner, Alina Schenk, Isabel Spier, Monika Warmuth-Metz, Brigitte Bison, Denise Obrecht, Nina Struve, Rolf-Dieter Kortmann, Matthias Schmid, Stefan Aretz, Stefan Rutkowski, Torsten Pietsch
This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations as possible prognostic markers in WNT-activated medulloblastoma (WNT-MB). In a cohort of 191 patients with WNT-MBs, mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f25a0e0ba90caea122b672003b0d1a
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/98937
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/98937
Autor:
Martin Mynarek, Tobias Goschzik, Marcel Kool, Katja von Hoff, Holger Ottensmeier, Monika Warmuth-Metz, Brigitte Bison, Martin Sill, Elisabeth Jane Rushing, Martin Hasselblatt, Arend Koch, Ulrich Schüller, Andreas von Deimling, Markus J Riemenschneider, Hildegard Dohmen, Camelia-Maria Monoranu, Clemens Sommer, Ori Staszewski, Christian Mawrin, Jens Schittenhelm, Wolfgang Brück, Katharina Filipski, Christian Hartmann, Matthias Meinhardt, Klaus Pietschmann, Christine Haberler, Irene Slavc, Nicolas U Gerber, Michael Grotzer, Martin Benesch, Paul-Gerhardt Schlegel, Frank Deinlein, Udo Bode, André O von Bueren, Carsten Friedrich, Denise Obrecht, Gudrun Fleischhack, Robert Kwiecien, Andreas Faldum, Rolf-Dieter Kortmann, Torsten Pietsch, Stefan Pfister, Stefan Rutkowski
PURPOSE: To assess outcomes and biological parameters of children younger than 4 years with metastatic medulloblastoma treated within the MET-HIT2000-BIS4 trial or outside the protocol. PATIENTS AND METHODS: 48 trial participants received either carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26187211dc17b2d398fb0478ac9803b1
Autor:
Mathias Yuan, Martin Mynarek, Tobias Goschzik, Elke Pfaff, Rolf Kortmann, Brigitte Bison, Monika Warmuth-Metz, Ulrich Schiller, Christian Hagel, Denise Obrecht, Martin Benesch, Stefan M Pfister, Torsten Pietsch, Stefan Rutkowski
Publikováno v:
Neuro-Oncology. 24:i11-i12
BACKGROUND: Pineoblastoma is a malignant tumor of the pineal gland and accounts for 4y differed according to metastatic status (M0 (n=40) 72.7±8.3%/75.0±8.3%; M+ (n=28) 28.7±10.3%/40.8±10.9%, p=0.001/0.001). Therapy escalation in M0 patients by g
Autor:
Maria Luisa Garrè, Maura Massimino, Francesca Romana Buttarelli, Lorenza Gandola, Salvina Barra, Felice Giangaspero, Tobias Goschzik, Veronica Biassoni, Lorenza Pastorino, Angela Pistorio, Torsten Pietsch
Publikováno v:
Neuro-Oncology. 24:i112-i113
AIMS: We report a cohort of YCMB cases homogeneously treated with HDCT in two Italian institutions, and the prognostic impact of histology and genetics retrospectively evaluated. METHODS: All YCMB (aged≤3 years) treated with upfront HDCT in the per