Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tobias Gerach"'
Publikováno v:
BioMedical Engineering OnLine, Vol 20, Iss 1, Pp 1-28 (2021)
Abstract Background Hypertrophic cardiomyopathy (HCM) is typically caused by mutations in sarcomeric genes leading to cardiomyocyte disarray, replacement fibrosis, impaired contractility, and elevated filling pressures. These varying tissue propertie
Externí odkaz:
https://doaj.org/article/ec4b253f44434f0a91ca08648e9be80c
Autor:
Tobias Gerach, Stephanie Appel, Jacek Wilczek, Krzysztof S. Golba, Tomasz Jadczyk, Axel Loewe
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Cardiac resynchronization therapy is a valuable tool to restore left ventricular function in patients experiencing dyssynchronous ventricular activation. However, the non-responder rate is still as high as 40%. Recent studies suggest that left ventri
Externí odkaz:
https://doaj.org/article/df954df6fa6e48c09ca3f889dc279eb9
Autor:
Jochen Brenneisen, Anna Daub, Tobias Gerach, Ekaterina Kovacheva, Larissa Huetter, Bettina Frohnapfel, Olaf Dössel, Axel Loewe
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: The human heart is a masterpiece of the highest complexity coordinating multi-physics aspects on a multi-scale range. Thus, modeling the cardiac function in silico to reproduce physiological characteristics and diseases remains challengin
Externí odkaz:
https://doaj.org/article/a1a001ca5e944b2f91c8b5ae01683ed0
Autor:
Tobias Gerach, Steffen Schuler, Jonathan Fröhlich, Laura Lindner, Ekaterina Kovacheva, Robin Moss, Eike Moritz Wülfers, Gunnar Seemann, Christian Wieners, Axel Loewe
Publikováno v:
Mathematics, Vol 9, Iss 11, p 1247 (2021)
Mathematical models of the human heart are evolving to become a cornerstone of precision medicine and support clinical decision making by providing a powerful tool to understand the mechanisms underlying pathophysiological conditions. In this study,
Externí odkaz:
https://doaj.org/article/4a0180b32450494cb929dc8f5f40076c
Publikováno v:
Cardiovascular Engineering and Technology
Purpose Atrial fibrillation is one of the most frequent cardiac arrhythmias in the industrialized world and ablation therapy is the method of choice for many patients. However, ablation scars alter the electrophysiological activation and the mechanic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9107ad3a87dc775930badf115893a18
https://publikationen.bibliothek.kit.edu/1000155483/150170503
https://publikationen.bibliothek.kit.edu/1000155483/150170503
Publikováno v:
Computing in Cardiology Conference (CinC).
Publikováno v:
Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 251-254 (2021)
Today a variety of models describe the physiological behavior of the heart on a cellular level. The intracellular calcium concentration plays an important role, since it is the main driver for the active contraction of the heart. Due to different imp
Publikováno v:
Current Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 95-98 (2020)
Over the last decades, computational models have been applied in in-silico simulations of the heart biomechanics. These models depend on input parameters. In particular, four parameters are needed for the constitutive law of Guccione et al., a model
Autor:
Tobias, Gerach, Stephanie, Appel, Jacek, Wilczek, Krzysztof S, Golba, Tomasz, Jadczyk, Axel, Loewe
Publikováno v:
Frontiers in physiology. 13
Cardiac resynchronization therapy is a valuable tool to restore left ventricular function in patients experiencing dyssynchronous ventricular activation. However, the non-responder rate is still as high as 40%. Recent studies suggest that left ventri
Publikováno v:
GEOPHYSICS. 84:B311-B324
Evidence for gas-hydrate occurrence in the Western Black Sea is found from seismic measurements revealing bottom-simulating reflectors (BSRs) of varying distinctness. From an ocean-bottom seismic data set, low-resolution traveltime-tomography models