Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tobias G Schips"'
Autor:
Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Jeffery D Molkentin
Publikováno v:
eLife, Vol 6 (2017)
Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013
Externí odkaz:
https://doaj.org/article/4aac43792af04e3fb223c85bf1c58adf
Autor:
Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin
Publikováno v:
eLife, Vol 5 (2016)
Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its
Externí odkaz:
https://doaj.org/article/211d0d632f9543a2ab9249ddaf6593b3
Autor:
Davy Vanhoutte, Tobias G. Schips, Rachel A. Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Vikram Prasad, Suh-Chin Lin, Michael J. Bround, Michelle A. Sargent, Christopher M. Adams, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114149- (2024)
Summary: Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle atrophy with age-dependent decreases in exercise capacity and prema
Externí odkaz:
https://doaj.org/article/cbb8ebd5e51b4718a055bc0a6afa780b
Autor:
Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyoc
Externí odkaz:
https://doaj.org/article/391d00d31af043e1bbe47abd09087451
Autor:
Tobias G. Schips, Davy Vanhoutte, Alexander Vo, Robert N. Correll, Matthew J. Brody, Hadi Khalil, Jason Karch, Andoria Tjondrokoesoemo, Michelle A. Sargent, Marjorie Maillet, Robert S. Ross, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopa
Externí odkaz:
https://doaj.org/article/74b8489711b44584b0c9cd975dc56e06
Autor:
Federica Accornero, Tobias G. Schips, Jennifer M. Petrosino, Shan-Qing Gu, Onur Kanisicak, Jop H. van Berlo, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing th
Externí odkaz:
https://doaj.org/article/6869b96703654f77bdb47ffe9c5e9636
Autor:
Robert N. Correll, Jeffrey M. Lynch, Tobias G. Schips, Vikram Prasad, Allen J. York, Michelle A. Sargent, Didier X. P. Brochet, Jianjie Ma, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Transverse tubules (t-tubules) are uniquely-adapted membrane invaginations in cardiac myocytes that facilitate the synchronous release of Ca2+ from internal stores and subsequent myofilament contraction, although these structures become diso
Externí odkaz:
https://doaj.org/article/e0793bad17014a878298a6f75b5f43f6
Autor:
Jeffery D. Molkentin, Federica Accornero, Jennifer M. Petrosino, Shan Qing Gu, Tobias G. Schips, Jop H. van Berlo, Onur Kanisicak
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
Regulation of mRNA splicing, processing and stability is increasingly recognized as a critical control point in dynamically altering gene expression during stress or disease. Very little is understood of this process in heart failure. Here, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefde683fb07cf69f343c969aafedd66
http://link.springer.com/article/10.1038/s41467-017-02005-1
http://link.springer.com/article/10.1038/s41467-017-02005-1
Autor:
Kelly M. Grimes, Michelle A. Sargent, Alexander Vo, Davy Vanhoutte, Tobias G. Schips, Tanya A. Baldwin, Matthew J. Brody, Jeffery D. Molkentin, Federica Accornero
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production. Here we show that Thbs1, but not Thbs2, Thbs3 or Thbs4, induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34e1c257a84a4cfe2833d7d7998f1be
https://pubmed.ncbi.nlm.nih.gov/34168130
https://pubmed.ncbi.nlm.nih.gov/34168130
Autor:
Hadi Khalil, Bryan D. Maliken, Ronald J. Vagnozzi, Jeffery D. Molkentin, Anne Katrine Z. Johansen, Vikram Prasad, Justin G. Boyer, Kunito Kawasaki, Robert N. Correll, Matthew J. Brody, Kazuhiro Nagata, Onur Kanisicak, Katja K. Kilian, Tobias G. Schips
Publikováno v:
JCI Insight
Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular chaperones are required for procollagen biosynthesis, including heat sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8bf71d129cb5da3acb83a5021115a7
https://doi.org/10.1172/jci.insight.128722
https://doi.org/10.1172/jci.insight.128722