Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Tobias Doerks"'
Autor:
Ivana Vonkova, Antoine-Emmanuel Saliba, Samy Deghou, Kanchan Anand, Stefano Ceschia, Tobias Doerks, Augustinus Galih, Karl G. Kugler, Kenji Maeda, Vladimir Rybin, Vera van Noort, Jan Ellenberg, Peer Bork, Anne-Claude Gavin
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1519-1530 (2015)
Many cellular processes involve the recruitment of proteins to specific membranes, which are decorated with distinctive lipids that act as docking sites. The phosphoinositides form signaling hubs, and we examine mechanisms underlying recruitment. We
Externí odkaz:
https://doaj.org/article/97ef8f3879ca4f83b893e2538afd84c9
Autor:
Carine F. Djuika, Jaime Huerta-Cepas, Jude M. Przyborski, Sophia Deil, Cecilia P. Sanchez, Tobias Doerks, Peer Bork, Michael Lanzer, Marcel Deponte
Publikováno v:
Microbial Cell, Vol 2, Iss 1, Pp 5-13 (2015)
Horizontal gene transfer has emerged as a crucial driving force for the evolution of eukaryotes. This also includes Plasmodium falciparum and related economically and clinically relevant apicomplexan parasites, whose rather small genomes have been sh
Externí odkaz:
https://doaj.org/article/c9bdf538bcf34ecfb4178e6c6e0ae2df
Autor:
Kalliopi Trachana, Kristoffer Forslund, Tomas Larsson, Sean Powell, Tobias Doerks, Christian von Mering, Peer Bork
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111122 (2014)
Accurate orthology prediction is crucial for many applications in the post-genomic era. The lack of broadly accepted benchmark tests precludes a comprehensive analysis of orthology inference. So far, functional annotation between orthologs serves as
Externí odkaz:
https://doaj.org/article/d24246b9e4a14841b46f80166b7ba9ed
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34302 (2012)
The genome of Mycobacterium tuberculosis (H37Rv) contains 4,019 protein coding genes, of which more than thousand have been categorized as 'hypothetical' implying that for these not even weak functional associations could be identified so far. We her
Externí odkaz:
https://doaj.org/article/feeed07e7f7040b7b8fd4affd1e26b6c
Autor:
Christopher J Creevey, Jean Muller, Tobias Doerks, Julie D Thompson, Detlev Arendt, Peer Bork
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 12, p e1002269 (2011)
The identification of single copy (1-to-1) orthologs in any group of organisms is important for functional classification and phylogenetic studies. The Metazoa are no exception, but only recently has there been a wide-enough distribution of taxa with
Externí odkaz:
https://doaj.org/article/071b686e981e41969b2a48c248e6cecb
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22099 (2011)
Single copy genes, universally distributed across the three domains of life and encoding mostly ancient parts of the translation machinery, are thought to be only rarely subjected to horizontal gene transfer (HGT). Indeed it has been proposed to have
Externí odkaz:
https://doaj.org/article/69d8765989154b2ebcb2998c4b3d94b8
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3515 (2008)
BackgroundPolyketides are a diverse group of biotechnologically important secondary metabolites that are produced by multi domain enzymes called polyketide synthases (PKS).Methodology/principal findingsWe have estimated frequencies of type I PKS (PKS
Externí odkaz:
https://doaj.org/article/3261e1002fea43c08699fcb7176d82e9
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3976 (2008)
Bacterial nitrile hydratase (NHases) are important industrial catalysts and waste water remediation tools. In a global computational screening of conventional and metagenomic sequence data for NHases, we detected the two usually separated NHase subun
Externí odkaz:
https://doaj.org/article/62b2fe4f090045d2815a4ad93584fd57
Autor:
Jan O Korbel, Tobias Doerks, Lars J Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D Hooper, Miguel A Andrade, Peer Bork
Publikováno v:
PLoS Biology, Vol 3, Iss 5, p e134 (2005)
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here
Externí odkaz:
https://doaj.org/article/dbc1889e4f1445f3b5c2e376ad3ef480
Autor:
Reinhard Büttner, Tobias Doerks, Nils Rahner, Magnus von Knebel-Doeberitz, Stefan Herms, Christoph Engel, Verena Steinke-Lange, Sukanya Horpaopan, Stefanie Holzapfel, Deepak Vangala, Juul T. Wijnen, Hans K. Schackert, Sascha B. Fischer, Monika Morak, Susanne Moebus, Stefan Aretz, Sophia Peters, Katrin Kayser, Isabel Spier, Peer Bork, Franziska Degenhardt, Per Hoffmann
Publikováno v:
International Journal of Cancer. 143:2800-2813
In many families with suspected Lynch syndrome (LS), no germline mutation in the causative mismatch repair (MMR) genes is detected during routine diagnostics. To identify novel causative genes for LS, the present study investigated 77 unrelated, muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ec338770ac0ae5c1cd02cb89dc9902d
https://doi.org/10.1002/ijc.31725
https://doi.org/10.1002/ijc.31725