Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Tobias D. Merson"'
Autor:
Yasuyuki Osanai, Yao Lulu Xing, Shinya Mochizuki, Kenta Kobayashi, Jihane Homman-Ludiye, Amali Cooray, Jasmine Poh, Ayumu Inutsuka, Nobuhiko Ohno, Tobias D. Merson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101288- (2024)
Molecular cloning techniques enabling contemporaneous expression of two or more protein-coding sequences provide an invaluable tool for understanding the molecular regulation of cellular functions. The Cre-lox system is used for inducing the expressi
Externí odkaz:
https://doaj.org/article/58ba34fea2c24f2c9fe996aecdcdaad2
Autor:
Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang, Kaveh Moradi, Stanislaw Mitew, William D. Richardson, Trevor J. Kilpatrick, Yasuyuki Osanai, Tobias D. Merson
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 2, Pp 100414- (2023)
Summary: Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) by targeted cell ablation in the rodent CNS have limitations in the extent and duration of OPC depletion. We have developed a pharmacogenetic approach for conditional OP
Externí odkaz:
https://doaj.org/article/ac75dafd8a5c4a4eab2d291381dfd8b3
Autor:
Anthony G. Boghdadi, Joshua Spurrier, Leon Teo, Mingfeng Li, Mario Skarica, Benjamin Cao, William C. Kwan, Tobias D. Merson, Susan K. Nilsson, Nenad Sestan, Stephen M. Strittmatter, James A. Bourne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Astrocytes are important players in ischemic stroke. Here, the authors use single nuclei transcriptomics to characterise marmoset astrocytes following brain injury. At functional level, they show that NogoAexpressing astrocytes limit macrophage infil
Externí odkaz:
https://doaj.org/article/7d7d2c9ecae3430ebc0d5c40de26ce6f
Autor:
Stanislaw Mitew, Ilan Gobius, Laura R. Fenlon, Stuart J. McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L. Gundlach, Linda J. Richards, Trevor J. Kilpatrick, Tobias D. Merson, Ben Emery
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferen
Externí odkaz:
https://doaj.org/article/dabe9ec425ca41538111396c6350e1d3
Autor:
Sepideh Motamed, Mark P. Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J. Crack, Tobias D. Merson, Marie-Isabel Aguilar, David I. Finkelstein, John S. Forsythe
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migrate long distances and engraft. To overcome these problems, previous research has demonstrated the use of biomaterial im
Externí odkaz:
https://doaj.org/article/ab37ac9151e2435e8ddbe6b4e2b0be95
Autor:
Lai Ling Tsang, Gang Li, Fuyuan Yang, Ye Chun Ruan, Zhihui Weng, Jiawei Huang, Tobias D Merson, Zeyuan Ji, Jiacheng Lin, Xiaohua Jiang, Chao Wan, Kin Pong U
Publikováno v:
Theranostics
Aims: Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in neonates and infants. Mesenchymal stromal cell (MSC)-based therapy is emerging as a promising treatment avenue for HIE. However, despite its enormous potential,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95970c2457ac3dcf67bbe568fedee116
http://europepmc.org/articles/PMC8690936
http://europepmc.org/articles/PMC8690936
Autor:
William C. Kwan, Benjamin Cao, James A. Bourne, Mario Skarica, Stephen M. Strittmatter, Anthony G. Boghdadi, Joshua Spurrier, Susan K. Nilsson, Mingfeng Li, Leon Teo, Nenad Sestan, Tobias D. Merson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Astrocytes play critical roles after brain injury, but their precise function is poorly defined. Utilizing single-nuclei transcriptomics to characterize astrocytes after ischemic stroke in the visual cortex of the marmoset monkey, we observed nearly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5827aa43cbbf6076dcd3796939ed0d33
https://doaj.org/article/7d7d2c9ecae3430ebc0d5c40de26ce6f
https://doaj.org/article/7d7d2c9ecae3430ebc0d5c40de26ce6f
Autor:
Yasuyuki Osanai, Yao Lulu Xing, Kenta Kobayashi, Jihane Homman-Ludiye, Amali Cooray, Jasmine Poh, Nobuhiko Ohno, Tobias D. Merson
Molecular cloning techniques enabling contemporaneous expression of two or more protein-coding sequences in a cell type of interest provide an invaluable tool for understanding the molecular regulation of cellular functions. DNA recombination employi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d758050259f73b3ed0b1d8720ab600a
https://doi.org/10.1101/2022.04.23.489261
https://doi.org/10.1101/2022.04.23.489261
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165673 (2016)
The cellular mechanisms that regulate the topographic arrangement of myelin internodes along axons remain largely uncharacterized. Recent clonal analysis of oligodendrocyte morphologies in the mouse optic nerve revealed that adjacent oligodendrocytes
Externí odkaz:
https://doaj.org/article/97c4774b6aa84ea19672534ca8eb8ae3
Autor:
Roberto Cappai, Margaret Ayers, Loredana Spoerri, Giuseppe D. Ciccotosto, Tobias D. Merson, Mun Joo Chuei, Ben Emery, Yao Lulu Xing, Phan H. Truong
Publikováno v:
Glia. 67:525-538
The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate nervous system development and myelin regeneration after injury. In this study, we investigated the role of amyloid precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699730c357874c70c501c8b39cdbdf61
https://doi.org/10.1002/glia.23561
https://doi.org/10.1002/glia.23561