Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Tobias Dörr"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract To withstand their internal turgor pressure and external threats, most bacteria have a protective peptidoglycan (PG) cell wall. The growth of this PG polymer relies on autolysins, enzymes that create space within the structure. Despite exten
Externí odkaz:
https://doaj.org/article/748da71e208647a6bc8ff8dc84bc4866
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012488 (2024)
Antimicrobial peptides (AMPs) are a promising tool with which to fight rising antibiotic resistance. However, pathogenic bacteria are equipped with several AMP defense mechanisms, whose contributions to AMP resistance are often poorly defined. Here,
Externí odkaz:
https://doaj.org/article/13625bc6db594ddda28eb38b5fe4b0da
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1011234 (2024)
Peptidoglycan (PG) is the main component of the bacterial cell wall; it maintains cell shape while protecting the cell from internal osmotic pressure and external environmental challenges. PG synthesis is essential for bacterial growth and survival,
Externí odkaz:
https://doaj.org/article/48b1ffeec5ee42c29fd68de000d010e0
Autor:
Christine E. Harper, Wenyao Zhang, Junsung Lee, Jung-Ho Shin, Megan R. Keller, Ellen van Wijngaarden, Emily Chou, Zhaohong Wang, Tobias Dörr, Peng Chen, Christopher J. Hernandez
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Mechanosensitive mechanisms are often used to sense damage to tissue structure, stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well recognized in eukaryotic systems, it is not known whether such a pr
Externí odkaz:
https://doaj.org/article/55c378c485e9407bae72177b781bbc90
Autor:
Nowrosh Islam, Misha I. Kazi, Katie N. Kang, Jacob Biboy, Joe Gray, Feroz Ahmed, Richard D. Schargel, Cara C. Boutte, Tobias Dörr, Waldemar Vollmer, Joseph M. Boll
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT β-Lactam antibiotics exploit the essentiality of the bacterial cell envelope by perturbing the peptidoglycan layer, typically resulting in rapid lysis and death. Many Gram-negative bacteria do not lyse but instead exhibit “tolerance,” t
Externí odkaz:
https://doaj.org/article/c4b7e0c5719345918cf7f34490526802
Autor:
Andrew N Murtha, Misha I Kazi, Richard D Schargel, Trevor Cross, Conrad Fihn, Vincent Cattoir, Erin E Carlson, Joseph M Boll, Tobias Dörr
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010307 (2022)
Antibiotic tolerance is an understudied potential contributor to antibiotic treatment failure and the emergence of multidrug-resistant bacteria. The molecular mechanisms governing tolerance remain poorly understood. A prominent type of β-lactam tole
Externí odkaz:
https://doaj.org/article/a72bff4ca83c403286627b0b9f6ecec6
Autor:
Anna Isabell Weaver, Laura Alvarez, Kelly M Rosch, Asraa Ahmed, Garrett Sean Wang, Michael S van Nieuwenhze, Felipe Cava, Tobias Dörr
Publikováno v:
eLife, Vol 11 (2022)
The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autol
Externí odkaz:
https://doaj.org/article/ce8640e6677d4f7285ca9c6bfe5a1bb9
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009624 (2021)
Vibrio cholerae is the causative agent of cholera, a notorious diarrheal disease that is typically transmitted via contaminated drinking water. The current pandemic agent, the El Tor biotype, has undergone several genetic changes that include horizon
Externí odkaz:
https://doaj.org/article/a3887e3f81f7459a90dec42cbd5b3eff
Autor:
Shannon G. Murphy, Andrew N. Murtha, Ziyi Zhao, Laura Alvarez, Peter Diebold, Jung-Ho Shin, Michael S. VanNieuwenhze, Felipe Cava, Tobias Dörr
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Synthesis and turnover of the bacterial cell wall must be tightly coordinated to avoid structural integrity failure and cell death. Details of this coordination are poorly understood, particularly if and how cell wall turnover enzymes are required fo
Externí odkaz:
https://doaj.org/article/3448cb1d79ee482086f35f91076bef55
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008892 (2020)
Externí odkaz:
https://doaj.org/article/0d2aeb7fa4024884b4c2b480e33f8376