Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tobias Bogner"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 2060-2066 (2012)
Cryptophycins are cytotoxic natural products that exhibit considerable activities even against multi-drug-resistant tumor cell lines. As fluorinated pharmaceuticals have become more and more important during the past decades, fluorine-functionalized
Externí odkaz:
https://doaj.org/article/1a8ba266108d484ebff6e7de7ca2b820
Autor:
Benedikt Sammet, Christine Weiß, Jens Conradi, Soledad Royo Gracia, Markus Nahrwold, Norbert Sewald, Ralf Palmisano, Felix Mertink, Thomas Preuße, Tobias Bogner
Publikováno v:
Journal of Medicinal Chemistry. 56:1853-1864
Tumor targeting anticancer drug conjugates that contain a tumor recognition motif (homing device) are of high current relevance. Cryptophycins, naturally occurring cytotoxic cyclo-depsipeptides, have been modified by total synthesis to provide analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5ce4e4972c259e90b93e7603d8df39
https://doi.org/10.1021/jm301346z
https://doi.org/10.1021/jm301346z
Autor:
Silvère Ngouela, Bruno Ndjakou Lenta, Etienne Tsamo, Yanick F. Fongang, Angelbert F. Awantu, Norbert Sewald, Jean Duplex Wansi, Tobias Bogner
Publikováno v:
ChemInform. 42
Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2-13). The structure of the new compound as well as those of the kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3862fd704b18673b154a6d2db4ec7937
https://doi.org/10.1002/chin.201142188
https://doi.org/10.1002/chin.201142188
Autor:
Tobias Bogner, Bruno Ndjakou Lenta, Angelbert F. Awantu, Jean Duplex Wansi, Yanick F. Fongang, Silvère Ngouela, Etienne Tsamo, Norbert Sewald
Publikováno v:
ResearcherID
Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2 - 13). The structure of the new compound as well as those of the k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949b33c93cd5958b3d4666fd757402a4
https://pub.uni-bielefeld.de/record/2394639
https://pub.uni-bielefeld.de/record/2394639
Publikováno v:
The Journal of organic chemistry. 75(20)
The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14c246788e173ee3d82b9b1cc344006
https://pubmed.ncbi.nlm.nih.gov/20857920
https://pubmed.ncbi.nlm.nih.gov/20857920
Publikováno v:
Organic letters. 12(5)
An endocyclic trans-amide linkage within the macrocyclic antitumor agent cryptophycin-52 was replaced by a 1,4-disubstituted 1H-1,2,3-triazole ring. Macrocyclisation of the triazole analogue was accomplished by macrolactamization as well as by Cu(I)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f219b6edccef5ecf674a708cab7b408e
https://pubmed.ncbi.nlm.nih.gov/20131817
https://pubmed.ncbi.nlm.nih.gov/20131817
Cryptophycins are a family of highly cytotoxic, cyclic depsipeptides. They display antitumour activity that is largely maintained for multidrug-resistant tumour cells. Cryptophycins are composed of four building blocks (units A-D) that correspond to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e8c4b7da64edd6b053b9a78f562cf2
https://doi.org/10.1002/chem.200901750
https://doi.org/10.1002/chem.200901750