Výsledky vyhledávání - "Tobias B. Beigl"

Akademický článek

Efficient and crucial quality control of HAP1 cell ploidy status

Autor: Tobias B. Beigl, Ine Kjosås, Emilie Seljeseth, Nina Glomnes, Henriette Aksnes

Publikováno v: Biology Open, Vol 9, Iss 11 (2020)

The near-haploid human cell line HAP1 recently became a popular subject for CRISPR/Cas9 editing, since only one allele requires modification. Through the gene-editing service at Horizon Discovery, there are at present more than 7500 edited cell lines

Externí odkaz: https://doaj.org/article/a844467042424c7aae47e00375a26a05

Zobrazit plný text záznamu

Abstract 2524: Critical interactions and tumor-specific mutations of Bcl-2 transmembrane domains revealed by a novel split luciferase assay

Autor: Tobias B. Beigl, Alexander Paul, Sandra Weller, Benjamin Schäfer, Walter E. Aulitzky, Hans-Georg Kopp, Thomas Fellmeth, Kristyna Pluhackova, Markus Rehm, Frank Essmann

Publikováno v: Cancer Research. 83:2524-2524

In intrinsic apoptosis, the interaction network of the Bcl-2 protein family controls the decision over life and death. Cells are sentenced to death when pro-apoptotic multidomain effector proteins BAX, BAK or BOK oligomerize and form pores in the mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e2d1fcc9c06019751f760ab2ac1349
https://doi.org/10.1158/1538-7445.am2023-2524

Zobrazit plný text záznamu

Abstract 3710: Synergistic cell death induction in ovarian cancer by cisplatin and ABT-199 is mediated by expression of NOXA

Autor: Benjamin Schaefer, Sandra Weller, Tobias B. Beigl, Klaus Schulze-Osthoff, Hans-Georg Kopp, Walter E. Aulitzky, Frank Essmann

Publikováno v: Cancer Research. 82:3710-3710

Ovarian cancer is among the top ten leading causes of cancer death in women worldwide with a mortality rate of roughly 5% among all cancer deaths. So far, there are no recommended screening tests for the early detection of ovarian cancer. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e75dcfb2e65343f0a06ba90407fa5611
https://doi.org/10.1158/1538-7445.am2022-3710

Zobrazit plný text záznamu

Abstract 3706: Double impact of ABT-199 by directly blocking anti-apoptotic BCL-2 and inhibiting MCL-1 via transactivation of NOXA

Autor: Sandra Weller, Benjamin Schaefer, Tobias B. Beigl, Kathrin Böpple, Ute Hofmann, Walter E. Aulitzky, Hans-Georg Kopp, Frank Essmann

Publikováno v: Cancer Research. 82:3706-3706

Soft-Tissue Sarcomas (STS) are mesenchymal malignancies with high heterogeneity and poor prognosis. As recently shown, ABT-199 and Bortezomib (BTZ) synergistically induce apoptosis in STS derived cells and cell lines (Muenchow et al. 2020). This is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::030360885db26d36fc5a5cfd1d1a253c
https://doi.org/10.1158/1538-7445.am2022-3706

Zobrazit plný text záznamu

Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids

Autor: Kai Cao, Peter Scheurich, Roland E. Kontermann, Tobias B. Beigl, Thomas E. Mürdter, Cathrin Hagenlocher, Alexandra Mack, Daniela Simone Maichl, Stephen W.G. Tait, Daniela Stöhr, Markus Rehm, Beate Budai, Jens O Schmid, Gavin Fullstone, Nadine Pollak

Publikováno v: Cell Death and Differentiation

The influence of 3D microenvironments on apoptosis susceptibility remains poorly understood. Here, we studied the susceptibility of cancer cell spheroids, grown to the size of micrometastases, to tumor necrosis factor-related apoptosis-inducing ligan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4746167a42442d4aa67874014f1dcaf8
https://eprints.gla.ac.uk/219472/1/219472.pdf

Zobrazit plný text záznamu

Abstract 1398: Impact of proteasome inhibitor specificity and efficacy on apoptosis induction by combination with ABT-199

Autor: Frank Essmann, Benjamin Schaefer, Walter E. Aulitzky, Tobias B. Beigl, Sandra Weller, Kathrin Böpple, Hans-Georg Kopp

Publikováno v: Cancer Research. 81:1398-1398

Metastatic Soft-Tissue Sarcomas (STS) are a rare and highly heterogeneous group of mesenchymal malignancies that carry a poor prognosis. Therapy is hampered by a limited number of effective treatments, and the almost non-existing long-term survival r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db1e6ce4ef486166454752872f928522
https://doi.org/10.1158/1538-7445.am2021-1398

Zobrazit plný text záznamu

Abstract 1947: Brought to light: the homotypic interaction pattern of Bcl-2 effector transmembrane domains in a bimolecular luciferase complementation assay

Autor: Sandra Weller, Lara-Sophie Rieder, Walter E. Aulitzky, Kathrin Böpple, Tobias B. Beigl, Benjamin Schäfer, Hans-Georg Kopp, Frank Essmann, Markus Rehm

Publikováno v: Cancer Research. 81:1947-1947

The intrinsic apoptosis signaling pathway comprises the intimate interaction network of the Bcl-2 protein family, in which both pro- and antiapoptotic members pushing cell fate to either survival or death. As a critical event, oligomerization of pore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a0db4dbdf1b94369e97a1e2a51dfd74
https://doi.org/10.1158/1538-7445.am2021-1947

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání