Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tobias, Speerschneider"'
Autor:
Bo Hjorth Bentzen, Sofia Hammami Bomholtz, Rafel Simó-Vicens, Lasse Folkersen, Lea Abildgaard, Tobias Speerschneider, Kalai Mangai Muthukumarasamy, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsSmall conductance Ca2+-activated K+ channels (SK channels, KCa2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of KCa2 channels that is currently in clinical development for treatment of AF. The
Externí odkaz:
https://doaj.org/article/f462fdae02ad4e698282f8bd9227d4e9
Autor:
Jonas Goldin Diness, Jeppe Egedal Kirchhoff, Tobias Speerschneider, Lea Abildgaard, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsTo describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistant
Externí odkaz:
https://doaj.org/article/5c0147df7d244338b19b09ac7b4cb339
Autor:
Jonas Tind Hansen, Christina Lyngsø, Tobias Speerschneider, Pernille B L Hansen, Céline Galés, David M Weiner, Søren P Sheikh, Ethan S Burstein, Jakob Lerche Hansen
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58890 (2013)
BACKGROUND: Functional cross-talk between seven transmembrane (7TM) receptors can dramatically alter their pharmacological properties, both in vitro and in vivo. This represents an opportunity for the development of novel therapeutics that potentiall
Externí odkaz:
https://doaj.org/article/5b51a6c1117a4f438c194d1e3a276b1d
Autor:
Jonas Goldin, Diness, Jeppe Egedal, Kirchhoff, Tobias, Speerschneider, Lea, Abildgaard, Nils, Edvardsson, Ulrik S, Sørensen, Morten, Grunnet, Bo Hjorth, Bentzen
Publikováno v:
Frontiers in Pharmacology
Aims To describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d63613cb828a5134e32c3a01bfca8792
https://pubmed.ncbi.nlm.nih.gov/32180722
https://pubmed.ncbi.nlm.nih.gov/32180722
Autor:
Tobias Speerschneider, Rafel Simó-Vicens, Bo Hjorth Bentzen, Jonas Goldin Diness, Bernardo Dolce, Morten Grunnet, Jeppe Egedal Kirchhoff, Lea Abildgaard, Ulrik Svane Sørensen
Publikováno v:
British Journal of Pharmacology. 174:4396-4408
Background and Purpose Small conductance calcium-activated potassium (KCa2) channels represent a promising atrial-selective target for treatment of atrial fibrillation. Here, we establish the mechanism of KCa2 channel inhibition by the new compound A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a92d7c83d2d5b0aebee866c6d20388
https://doi.org/10.1111/bph.14043
https://doi.org/10.1111/bph.14043
Autor:
Jussi T. Koivumäki, Kirstine Calloe, Søren Grubb, Søren-Peter Olesen, Lisa A. Gottlieb, Nancy Mutsaers, Tobias Speerschneider, Morten B. Thomsen, Gary L. Aistrup
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 309:H481-H489
Inherited ion channelopathies and electrical remodeling in heart disease alter the cardiac action potential with important consequences for excitation-contraction coupling. Potassium channel-interacting protein 2 (KChIP2) is reduced in heart failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97de6d6755a224f4f829da8ea8590b58
https://doi.org/10.1152/ajpheart.00166.2015
https://doi.org/10.1152/ajpheart.00166.2015
Autor:
Rafel, Simó-Vicens, Jeppe E, Kirchhoff, Bernardo, Dolce, Lea, Abildgaard, Tobias, Speerschneider, Ulrik S, Sørensen, Morten, Grunnet, Jonas G, Diness, Bo H, Bentzen
Publikováno v:
British journal of pharmacology. 174(23)
Small conductance calcium-activated potassium (KUsing site-directed mutagenesis, binding determinants for AP14145 inhibition were explored. AP14145 selectivity and mechanism of action were investigated by patch-clamp recordings of heterologously expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::584cefb779c8321257eeb3242096ff21
https://pubmed.ncbi.nlm.nih.gov/28925012
https://pubmed.ncbi.nlm.nih.gov/28925012
Autor:
Søren-Peter Olesen, Kirstine Calloe, Morten B. Thomsen, Tobias Speerschneider, Dona Occhipinti, Søren Grubb, Céline Fiset
Publikováno v:
Journal of Cardiovascular Electrophysiology. 25:896-904
The Role of KChIP2 in Heart Failure Introduction KV4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f) in the heart. KChIP2 is downregulated in human heart failure (HF), po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc503879a475e0ad81e2788f2f6fd63b
https://doi.org/10.1111/jce.12422
https://doi.org/10.1111/jce.12422
Autor:
Morten B. Thomsen, Tobias Speerschneider, Søren Grubb, Kirstine Calloe, Artina Metoska, Søren-Peter Olesen
Publikováno v:
The Journal of Physiology. 591:5923-5937
Key points • Previous studies have suggested that the K+ channel auxiliary subunit K+ channel-interacting protein 2 (KChIP2) serves as a regulator of cardiac remodelling leading to heart failure and increased risk of arrhythmias. • The results pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b3590364b2188b181103ed91821754
https://doi.org/10.1113/jphysiol.2013.263483
https://doi.org/10.1113/jphysiol.2013.263483
Publikováno v:
Acta Physiologica. 209:262-271
Aim The murine electrocardiogram (ECG) is a valuable tool in cardiac research, although the definition of the T wave has been a matter of debate for several years potentially leading to incomparable data. By this study, we seek to make a clear defini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b3ee52d96e80c8d62c71fa70ca69e4
https://doi.org/10.1111/apha.12172
https://doi.org/10.1111/apha.12172