Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tobias, Mühlethaler"'
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Beatrice Wagner, Florian P. C. Binder, Xiaohua Jiang, Tobias Mühlethaler, Roland C. Preston, Said Rabbani, Martin Smieško, Oliver Schwardt, Beat Ernst
Publikováno v:
Molecules, Vol 28, Iss 6, p 2595 (2023)
The d-GlcNAc moiety in sialyl Lewisx (sLex, 1) acts predominantly as a linker to position the d-Gal and the l-Fuc moieties in the bioactive spatial orientation. The hypothesis has been made that the NHAc group of GlcNAc pushes the fucose underneath t
Externí odkaz:
https://doaj.org/article/09c92691cdac462f95168204e153b667
Autor:
Nathália Moreno Cury, Tobias Mühlethaler, Angelo Brunelli Albertoni Laranjeira, Rafael Renatino Canevarolo, Priscila Pini Zenatti, Daniel Lucena-Agell, Isabel Barasoain, Chunhua Song, Dongxiao Sun, Sinisa Dovat, Rosendo Augusto Yunes, Andrea Enrico Prota, Michel Olivier Steinmetz, José Fernando Díaz, José Andrés Yunes
Publikováno v:
iScience, Vol 21, Iss , Pp 95-109 (2019)
Summary: Tubulin is one of the best validated anti-cancer targets, but most anti-tubulin agents have unfavorable therapeutic indexes. Here, we characterized the tubulin-binding activity, the mechanism of action, and the in vivo anti-leukemia efficacy
Externí odkaz:
https://doaj.org/article/67ad75df1ed143b6b2d81f30461805ab
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6031650b263dc281c6bcce2894cf2134
https://doi.org/10.7554/elife.84791.sa2
https://doi.org/10.7554/elife.84791.sa2
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Christopher Milne, Andrea Cavalli, Josef Wachtveitl, Michel Steinmetz, Jörg Standfuss
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a72c6a2aafb8c867ef93395e8b9fb46
https://doi.org/10.21203/rs.3.rs-1964458/v1
https://doi.org/10.21203/rs.3.rs-1964458/v1
Autor:
Hayley M. McDaid, Nancy R. Zhang, Andrea E. Prota, Alicia Rodriguez-Gabin, Tobias Mühlethaler, Michel O. Steinmetz, Kenny Ye, Amos B. Smith, Boying Guo, Susan Band Horwitz
Publikováno v:
Mol Pharmacol
The natural product (+)-discodermolide (DDM) is a microtubule stabilizing agent and potent inducer of senescence. We refined the structure of DDM and evaluated the activity of novel congeners in triple negative breast and ovarian cancers, malignancie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f91a5c25c2181a1b575a7fd5eba75df
https://doi.org/10.1124/mol.119.117457
https://doi.org/10.1124/mol.119.117457
Autor:
Tobias, Mühlethaler, Natacha, Olieric, Valentin A, Ehrhard, Maximilian, Wranik, Jörg, Standfuss, Ashwani, Sharma, Andrea E, Prota, Michel O, Steinmetz
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2430
Since the first moderate resolution, structural description of Taxol bound to tubulin by electron crystallography in 1998, several tubulin crystal systems have been developed and optimized for the high-resolution analysis of tubulin-ligand complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ca190ebc2b55e0f93a1e7e921339d7d
https://pubmed.ncbi.nlm.nih.gov/35476344
https://pubmed.ncbi.nlm.nih.gov/35476344
Autor:
Tobias Mühlethaler, Lampros Milanos, Jose Antonio Ortega, Thorsten B. Blum, Dario Gioia, Bibhas Roy, Andrea E. Prota, Andrea Cavalli, Michel O. Steinmetz
Publikováno v:
Angewandte Chemie. 134
In this study, we capitalized on our previously performed crystallographic fragment screen and developed the antitubulin small molecule Todalam with only two rounds of straightforward chemical synthesis. Todalam binds to a novel tubulin site, disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be20c20dcf6329e2f1ea656f9d1964d0
https://doi.org/10.1002/ange.202204052
https://doi.org/10.1002/ange.202204052
Autor:
Ilaria Callegari, Mika Schneider, Giuliano Berloffa, Tobias Mühlethaler, Sebastian Holdermann, Edoardo Galli, Tim Roloff, Renate Boss, Laura Infanti, Nina Khanna, Adrian Egli, Andreas Buser, Gert Zimmer, Tobias Derfuss, Nicholas S R Sanderson
Publikováno v:
Callegari, Ilaria; Schneider, Mika; Berloffa, Giuliano; Mühlethaler, Tobias; Holdermann, Sebastian; Galli, Edoardo; Roloff, Tim; Boss, Renate; Infanti, Laura; Khanna, Nina; Egli, Adrian; Buser, Andreas; Zimmer, Gert; Derfuss, Tobias; Sanderson, Nicholas S R (2022). Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch. EMBO reports, 23(7), e53956. EMBO press 10.15252/embr.202153956
To investigate the class-dependent properties of anti-viral IgM antibodies, we use membrane antigen capture activated cell sorting to isolate spike-protein-specific B cells from donors recently infected with SARS-CoV-2, allowing production of recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8deff3b366d2a75cb1f6bcdd9e36e97
https://pubmed.ncbi.nlm.nih.gov/35548920
https://pubmed.ncbi.nlm.nih.gov/35548920