Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Tobias, Grob"'
Autor:
Simon L. April-Monn, Philipp Kirchner, Katharina Detjen, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous malignancy. We established patient-de
Externí odkaz:
https://doaj.org/article/4501b816ee864b8c8c471a5b031bef76
Autor:
Dennis Hoch, Manuela Rabaglio, Tobias Grob, Michael von Gunten, Jörg Beyer, Dilara Akhoundova
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 1280-1286 (2023)
Mismatch repair-deficient (dMMR) prostate cancer (PCa) is a rare (1–5%) but highly actionable molecular subgroup of PCa, vulnerable to immune checkpoint inhibitors. Our case of sporadic dMMR PCa due to large monoallelic co-deletion of EPCAM, MSH2,
Externí odkaz:
https://doaj.org/article/72b6acf28ae945e6910516cdc196dfa0
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 871-877 (2023)
In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of thes
Externí odkaz:
https://doaj.org/article/057b934bc8824803a930934fdce6200c
Autor:
Juliane Friemel, Irianna Torres, Elizabeth Brauneis, Tim Thörner, Alejandro A. Schäffer, E. Michael Gertz, Tobias Grob, Kati Seidl, Achim Weber, Thomas Ried, Kerstin Heselmeyer-Haddad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor, nonalcoholic fatty liver disease (NAFLD) are an unmet health issue due to widespread obesity. We assessed copy number changes of genes associated w
Externí odkaz:
https://doaj.org/article/10d6221a6a564d01ae9307dfc0dda781
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Supplementary Figure 1. Inhibitory effect of Cetuximab determined by western blot analysis of 12 HNSCC cell line lysates. Supplementary Figure 2. Time course of EGFR phosphorylation in HNSCC cell line UT-SCC 8. Supplementary Figure 3. Correlation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2861dab98115ba59a2863d22258b88
https://doi.org/10.1158/0008-5472.22416219.v1
https://doi.org/10.1158/0008-5472.22416219.v1
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Supplementary Table 1 Patient characteristics including EGFRK521 allele frequency. Supplementary Table 2 Characteristics and sequencing data of squamous cell carcinoma cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf07edc18e7ba91ca942179f80df7e1
https://doi.org/10.1158/0008-5472.22416216
https://doi.org/10.1158/0008-5472.22416216
Autor:
Mascha Binder, Carsten Bokemeyer, Sonja Loges, Boris Fehse, Kristoffer Riecken, Rainald Knecht, Martin Trepel, Bruno Märkl, Elzbieta Jakubowicz, Steffen Goletz, Antje Danielczyk, Simon Laban, Ingke Braren, Isabel Ben Batalla, Anja Thalhammer, Markus Sack, Veronique Blanchard, Karina Biskup, Tobias Grob, Beate Habel, Minna Voigtlaender, Malte Kriegs, Friederike Braig
Head and neck squamous cell carcinomas (HNSCC) exhibiting resistance to the EGFR-targeting drug cetuximab poses a challenge to their effective clinical management. Here, we report a specific mechanism of resistance in this setting based upon the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25965099290cbcc9845191154ace7fe
https://doi.org/10.1158/0008-5472.c.6509496.v1
https://doi.org/10.1158/0008-5472.c.6509496.v1
Autor:
Simon L. April-Monn, Katharina Detjen, Philipp Kirchner, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous epithelial malignancy. We established patient-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb14c55c77b4f97ea94822d0fdde77a
https://doi.org/10.1101/2022.12.10.519855
https://doi.org/10.1101/2022.12.10.519855
Publikováno v:
IEEE Design & Test. 35:63-74
Editor’s note: You all know this from watching CSI: When a crime is committed, usually some form of digital evidence is left on devices such as computers, mobile phones, or the navigation system of a car a suspect has used. Indeed, law enforcement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38cc37017fd1e7e228f912cf1dc8d8f5
https://doi.org/10.1109/mdat.2018.2862366
https://doi.org/10.1109/mdat.2018.2862366
Autor:
Tobias Grob, Kerstin Borgmann, Arne Böttcher, Adrian Münscher, Waldemar Wilczak, Till S. Clauditz, Guido Sauter, Henning Hanken
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 144:53-61
FGFR1 is a receptor tyrosine kinases involved in tumor growth signaling, survival, and differentiation in many solid cancer types. There is growing evidence that FGFR1 amplification might predict therapy response to FGFR1 inhibitors in squamous cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea3dd215692684c06c65ec834d1de42
https://doi.org/10.1007/s00432-017-2528-x
https://doi.org/10.1007/s00432-017-2528-x