Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Tobias, Boettler"'
Autor:
Dorothea Dehnen, Tobias Boettler, Hartmut Hengel, Jürgen in der Schmitten, Suzan Botzenhardt, Benjamin Borchardt, Stephanie Vollmer-Raschdorf, Jassin Rashidi-Alavijeh, Sebastian Voigt, Daniela Huzly, Eva-Maria Hüßler, Anne Halenius, Katharina Willuweit, Mirko Trilling
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Introduction Shingrix, an effective adjuvanted, recombinant herpes zoster vaccine (RZV), has been available since 2018. Immunocompromised patients are known to be predisposed to vaccine failure. In-vitro testing of immunological surrogates of vaccine
Externí odkaz:
https://doaj.org/article/565b1c27c7b643a69c51aa08b6cf88e0
Autor:
Lukas Sturm, Misa Hirose, Laura Stolz, Michael Schultheiss, Katharina Zoldan, Marlene Reincke, Jan Patrick Huber, Rafael Kaeser, Tobias Boettler, Robert Thimme, Elisabeth Albert, Hauke Busch, Axel Künstner, Dominik Bettinger
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Recent studies have linked proton pump inhibitor (PPI) treatment to increased complications of cirrhosis, such as bacterial infections and hepatic encephalopathy. However, the underlying pathophysiological mechanisms remain unclear. The pres
Externí odkaz:
https://doaj.org/article/e841650409eb40b89821619cd8c12ecb
Autor:
Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David B. Reeg, Valerie Oberhardt, Natascha Roehlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 me
Externí odkaz:
https://doaj.org/article/fca8aca08c224586bb686b0fe9b5ffd3
Autor:
Katharina Wild, Maike Smits, Saskia Killmer, Shirin Strohmeier, Christoph Neumann-Haefelin, Bertram Bengsch, Florian Krammer, Martin Schwemmle, Maike Hofmann, Robert Thimme, Katharina Zoldan, Tobias Boettler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Understanding individual variations in the response to seasonal influenza vaccines has broad implications from basic immunology to public health. Here authors show that influenza hemagglutinin-specific T and B cell responses are determined by the pre
Externí odkaz:
https://doaj.org/article/5ecdcebcaf7d4d5180dbe8bfd157f337
Autor:
Miriam Fritz-Weltin, Estelle Frommherz, Nora Isenmann, Lisa Niedermeier, Benedikt Csernalabics, Tobias Boettler, Christoph Neumann-Haefelin, Dominique Endres, Marcus Panning, Benjamin Berger
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. An association with neuralgic amyotrophy and Guillain-Barré syndrome (GBS) was previously described. Concerning GBS, studies from other countrie
Externí odkaz:
https://doaj.org/article/dc91951f816143e99049047186e529e8
Autor:
Tobias Boettler, Upkar S. Gill, Lena Allweiss, Teresa Pollicino, John E. Tavis, Fabien Zoulim
Publikováno v:
JHEP Reports, Vol 4, Iss 6, Pp 100480- (2022)
Summary: Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that
Externí odkaz:
https://doaj.org/article/c73505d934a64b0292ee760cf659529d
Autor:
Anna-Maria Globig, Nikola Patricia Sommer, Katharina Wild, Josefine Schardey, Katharina Zoldan, Anne Kerstin Thomann, Lucas-Alexander Schulte, Rupert Schreiner, Wolfgang Reindl, Jochen Klaus, Christoph Mathis Schempp, Maike Hofmann, Robert Thimme, Tobias Boettler, Peter Hasselblatt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 1-12 (2021)
Background & aims: The pathogenesis of chronic inflammatory bowel diseases (Crohn’s disease [CD] and ulcerative colitis) involves dysregulated TH1 and TH17 cell responses, which can be targeted therapeutically by the monoclonal antibody Ustekinumab
Externí odkaz:
https://doaj.org/article/3f4907d75eda44b7956b621be2fdf692
Autor:
Frédérique Kok, Marcus Rosenblatt, Melissa Teusel, Tamar Nizharadze, Vladimir Gonçalves Magalhães, Christopher Dächert, Tim Maiwald, Artyom Vlasov, Marvin Wäsch, Silvana Tyufekchieva, Katrin Hoffmann, Georg Damm, Daniel Seehofer, Tobias Boettler, Marco Binder, Jens Timmer, Marcel Schilling, Ursula Klingmüller
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp 1-32 (2020)
Abstract Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that
Externí odkaz:
https://doaj.org/article/0f487b7e463c482f8349a29b3ad0fd4c
Autor:
Lukas Sturm, Dominik Bettinger, Lisa Roth, Katharina Zoldan, Laura Stolz, Chiara Gahm, Jan Patrick Huber, Marlene Reincke, Rafael Kaeser, Tobias Boettler, Wolfgang Kreisel, Robert Thimme, Michael Schultheiss
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Introduction: Despite intensive research, reliable blood-derived parameters to detect clinically significant portal hypertension (CSPH) in patients with cirrhosis are lacking. As altered homeostasis of cyclic guanosine monophosphate (cGMP), the centr
Externí odkaz:
https://doaj.org/article/86435637f41642d4b1ce7393ac66252e
Autor:
Katharina Zoldan, Sabine Ehrlich, Saskia Killmer, Katharina Wild, Maike Smits, Marissa Russ, Anna-Maria Globig, Maike Hofmann, Robert Thimme, Tobias Boettler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Circulating Th1-biased follicular T helper (cTfh1) cells have been associated with antibody responses to viral infection and after vaccination but their B cell helper functionality is less understood. After viral elimination, Tfh1 cells are the domin
Externí odkaz:
https://doaj.org/article/895155876c274890bd036e105668b36b