Zobrazeno 1 - 10
of 23
pro vyhledávání: '"To Kwong-Him"'
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 69 (2012)
Abstract Background Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found. High expression of the p53-antagonist MDM2 in hu
Externí odkaz:
https://doaj.org/article/ec39998c72124a8fa5f5a6390c741282
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 71K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1e12a2827bef15e4c7f52b8f26d01a
https://doi.org/10.1158/0008-5472.22398773.v1
https://doi.org/10.1158/0008-5472.22398773.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 12K, Antitumor activity of RG7112 against a panel of solid tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9c982ff418c10759c503fddf33cbb1
https://doi.org/10.1158/0008-5472.22398764.v1
https://doi.org/10.1158/0008-5472.22398764.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 1272K, Comparison of MDM2 binding properties of RG7112 and nutlin-3a (S1); Overlay of the crystal structures of MDM2 bound to RG7112 and Nutlin-2 (S2); RG7112 is a non-genotoxic p53 activator (S3); Effect of RG7112 on the viability of HCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed0ac5a589251b018ba5a026af7a98e
https://doi.org/10.1158/0008-5472.22398770
https://doi.org/10.1158/0008-5472.22398770
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 136K, Includes HTRF, cell growth/viability, apoptosis assays and biacore, crystal structure and animal studies. Also includes supplemental references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462335161b3d3a7a48af64749143adb9
https://doi.org/10.1158/0008-5472.22398767.v1
https://doi.org/10.1158/0008-5472.22398767.v1
Autor:
Chang, Yong S., Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A., Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z., Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E., Horstick, James, Annis, D. Allen, Manning, Anthony M., Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T., Sawyer, Tomi K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2013 Sep 01. 110(36), 14519-14519.
Externí odkaz:
https://www.jstor.org/stable/42713145
Autor:
Krzysztof Darlak, Hongliang Cai, Eric Feyfant, Tomi K. Sawyer, Packman Kathryn E, Lyubomir T. Vassilev, Christian Tovar, Carl Elkin, Huw M. Nash, James Horstick, D. Allen Annis, Vincent Guerlavais, Anthony M. Manning, Nader Fotouhi, Aditi Mukherjee, Xiangguo E. Shi, Karen A. Olson, Kwong-Him To, Kamala Kesavan, Yong S. Chang, Pamela Berry, Theresa Baker, Zoran Filipovic, Bradford Graves, Farooq Qureshi, Pranoti Gangurde
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Stapled α-helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we report a potent and selective dual inhibitor of MDM2 and MDMX, ATSP-7041, which effectively activates the p53 pathway in tumors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bf7583698e4f39a7bb9cea1d284dbf
https://doi.org/10.1073/pnas.1303002110
https://doi.org/10.1073/pnas.1303002110
Autor:
Edmund Lee, Frank John Podlaski, Mingxuan Xia, Zoran Filipovic, Christian Tovar, Bradford Graves, Peter Michael Wovkulich, Rosario Garrido, Kwong-Him To, Christine Tardell, Kenneth Kolinsky, Lyubomir T. Vassilev, Brian Higgins, Michael Linn, Binh Thanh Vu, Packman Kathryn E
Publikováno v:
Cancer research. 73(8)
MDM2 negatively regulates p53 stability and many human tumors overproduce MDM2 as a mechanism to restrict p53 function. Thus, inhibitors of p53-MDM2 binding that can reactivate p53 in cancer cells may offer an effective approach for cancer therapy. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e06251d7077c0ea5ca6f9d861db710
https://pubmed.ncbi.nlm.nih.gov/23400593
https://pubmed.ncbi.nlm.nih.gov/23400593
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 69 (2012)
BMC Cancer
BMC Cancer
Background Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found. High expression of the p53-antagonist MDM2 in human retin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2622bec8501adc0733f49c6c1d5bb0
https://doi.org/10.1186/1471-2407-12-69
https://doi.org/10.1186/1471-2407-12-69
Autor:
To, Kwong Him
Retinoblastoma development is a multistep process, and inactivation of the RB1 gene is not sufficient for tumorigenesis. Previous studies suggest that the p53-tumor suppressor is inactivated due to overexpression of p53-antagonists MDM4 and MDM2. Thi
Externí odkaz:
http://hdl.handle.net/1807/18965