Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury

Autor: Denise Veltman, Piet Claus, Ellen Caluwé, Maarten Vanhaverbeke, Uwe Himmelreich, Stefan Janssens, Peter Pokreisz, Peter Sinnaeve, Willy Gsell, Ming Wu, Hilde Gillijns

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • The role of the CLEC4E during myocardial healing after ischemia-reperfusion injury is unknown. • CLEC4E deletion is associated with reduced cardiac injury, inflammation, and left ventricular structural and functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a46fac4ecaf99cf50513516da72175
https://lirias.kuleuven.be/handle/123456789/680542

An IL-6-IL-8 score derived from principal component analysis is predictive of adverse outcome in acute myocardial infarction

Autor: Gisela A Kristono, Scott A. Harding, Kathryn E Hally, Ana Holley, Peter D. Larsen, B. Shi, Morgane M. Brunton-O'Sullivan

Publikováno v: Cytokine
Cytokine: X, Vol 2, Iss 4, Pp 100037-(2020)

Highlights • Principal component analysis (PCA) can create scores from collinear markers. • This study shows a PCA-derived score can combine cytokines in AMI patients. • An IL-6-IL-8 score using PCA independently predicts poor outcomes in AMI.<

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb0ce9badd3cc2ba830b19651acf81b
https://pubmed.ncbi.nlm.nih.gov/33604561

Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles

Autor: Derrick, Akpalu, Gale, Newman, Mark, Brice, Mike, Powell, Rajesh, Singh, Alexander, Quarshie, Elizabeth, Ofili, James, Fonger, Nic, Chronos, David, Feldman

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • The occurrence of an MI activates production of TFMPs. • We induced an MI in Yucatan miniswine and collected plasma samples over a 6-month period post-MI. • Experimental groups consisted of infarcted but untrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e625b10fa1ae724ca8dc31f5e2c742f
https://pubmed.ncbi.nlm.nih.gov/30062169

Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T

Autor: Jian Ping Jin, Shirin Akhter

Publikováno v: FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 64-75 (2015)

Highlights • Mutations in the TnT-interface of cardiac TnI cause cardiomyopathies. • Mutations A117G and K118C resulted in distinct changes in protein conformation. • K118C, but not A117G, decreased the binding affinity for TnT. • K118C decre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18850f774c1c83163600330547c8cc62

Prognostic value of biochemical parameters among severe COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa.

Autor: Zemlin AE; Division of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa., Allwood B; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Erasmus RT; Division of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa., Matsha TE; Faculty of Health and Wellness Sciences, Peninsula University of Technology, Bellville Campus, Cape Town, South Africa., Chapanduka ZC; Division of Haematological Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa., Jalavu TP; Division of Chemical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg Hospital, Cape Town, South Africa., Ngah V; Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Sigwadhi LN; Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Koegelenberg CF; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Irusen E; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Lalla U; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Yalew A; Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Department of Statistics, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.; National Data Management Centre for Health, Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Baines N; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Tamuzi JL; Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Barasa AK; Department of Human Pathology, School of Medicine, University of Nairobi, Nairobi, Kenya., Magutu VK; Department of Human Pathology, School of Medicine, University of Nairobi, Nairobi, Kenya., Njeru C; Department of Human Pathology, School of Medicine, University of Nairobi, Nairobi, Kenya., Amayo A; Department of Human Pathology, School of Medicine, University of Nairobi, Nairobi, Kenya., Mureithi MW; Department of Human Pathology, School of Medicine, University of Nairobi, Nairobi, Kenya., Mungania M; Department of Pathology, Kenyatta National Hospital, Nairobi, Kenya., Sono-Setati M; Department of Public Health Medicine, Department of Health, Limpopo, South Africa., Zumla A; Center for Clinical Microbiology, Division of Infection and Immunity, University College London, NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom., Nyasulu PS; Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Publikováno v: IJID regions [IJID Reg] 2022 Mar; Vol. 2, pp. 191-197. Date of Electronic Publication: 2022 Jan 23.