Zobrazeno 1 - 10
of 645
pro vyhledávání: '"Tn-seq"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 3, Pp 540-548 (2024)
The chromosomal position effect can significantly affect the transgene expression, which may provide an efficient strategy for the inauguration of alien genes in new hosts, but has been less explored rationally. The bacterium Myxococcus xanthus harbo
Externí odkaz:
https://doaj.org/article/9b5a8bec08b840828c03b3855128b2aa
Publikováno v:
mLife, Vol 3, Iss 2, Pp 277-290 (2024)
Abstract Most in silico evolutionary studies commonly assumed that core genes are essential for cellular function, while accessory genes are dispensable, particularly in nutrient‐rich environments. However, this assumption is seldom tested genetica
Externí odkaz:
https://doaj.org/article/5918481c428a43a09bfc91c6e9c7493d
Autor:
R. Blake Billmyre
Publikováno v:
mSphere, Vol 9, Iss 10 (2024)
ABSTRACT Blake Billmyre uses functional genomics to help understand the biology of fungal pathogens, with an emphasis on evolution of virulence relevant traits and drug resistance. In this mSphere of Influence article, he reflects on how two papers (
Externí odkaz:
https://doaj.org/article/d08225b2374b48388f7100022d6d6f77
Autor:
Chaoyue Pang, Ling Jin, Haoyu Zang, Damalk Saint-Claire S. Koklannou, Jiazhi Sun, Jiawei Yang, Yongxing Wang, Liang Xu, Chunyan Gu, Yang Sun, Xing Chen, Yu Chen
Publikováno v:
Journal of Integrative Agriculture, Vol 23, Iss 5, Pp 1580-1592 (2024)
Xanthomonas spp. cause severe bacterial diseases. However, effective strategies for prevention and management of these diseases are scarce. Thus, it is necessary to improve the efficiency of control of diseases caused by Xanthomonas. In this study, X
Externí odkaz:
https://doaj.org/article/e1e243734b994f27a950f6583516c233
Autor:
Louise H. Lefrançois, Jahn Nitschke, Huihai Wu, Gaël Panis, Julien Prados, Rachel E. Butler, Tom A. Mendum, Nabil Hanna, Graham R. Stewart, Thierry Soldati
Publikováno v:
mSystems, Vol 9, Iss 2 (2024)
ABSTRACTTuberculosis remains the most pervasive infectious disease and the recent emergence of drug-resistant strains emphasizes the need for more efficient drug treatments. A key feature of pathogenesis, conserved between the human pathogen Mycobact
Externí odkaz:
https://doaj.org/article/6f8ef12fa85142f6917fe6f2d44a0b6b
Autor:
Aretha Fiebig, Matthew K. Schnizlein, Selymar Pena-Rivera, Florian Trigodet, Abhishek Anil Dubey, Miette K. Hennessy, Anindita Basu, Sebastian Pott, Sushila Dalal, David Rubin, Mitchell L. Sogin, A. Murat Eren, Eugene B. Chang, Sean Crosson
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTBacteroides fragilis comprises 1%–5% of the gut microbiota in healthy humans but can expand to >50% of the population in ulcerative colitis (UC) patients experiencing inflammation. The mechanisms underlying such microbial blooms are poorly
Externí odkaz:
https://doaj.org/article/04ba6da4d1ee4dad828762f99f95006d
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The antibacterial activity of rifamycins specifically relies on the inhibition of transcription by directly binding to the β-subunit of bacterial DNA-dependent RNA polymerase (RNAP). However, its killing efficacy is substantially diminished
Externí odkaz:
https://doaj.org/article/b4db7f531a9e4367960e71428cc444cb
Autor:
Stefanie L. Vogt, Antonio Serapio-Palacios, Sarah E. Woodward, Andrew S. Santos, Stefan P.W. de Vries, Michelle C. Daigneault, Lisa V. Brandmeier, Andrew J. Grant, Duncan J. Maskell, Emma Allen-Vercoe, B. Brett Finlay
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTEnterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea, with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC colonizes the colon, which is also home to a diverse community of
Externí odkaz:
https://doaj.org/article/a5f7afa6035e4f5d813c2f4dd3f81e59
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 6, Pp 1-22 (2023)
Abstract In bacteria, natural transposon mobilization can drive adaptive genomic rearrangements. Here, we build on this capability and develop an inducible, self‐propagating transposon platform for continuous genome‐wide mutagenesis and the dynam
Externí odkaz:
https://doaj.org/article/32cd5e4f5b854b8a8c7b26deef4c5bc5
Autor:
Xi Liu, Minlu Jia, Jing Wang, Hang Cheng, Zhao Cai, Zhaoxiao Yu, Yang Liu, Luyan Z. Ma, Lianhui Zhang, Yingdan Zhang, Liang Yang
Publikováno v:
mLife, Vol 2, Iss 1, Pp 28-42 (2023)
Abstract Pseudomonas aeruginosa is one of the leading nosocomial pathogens that causes both severe acute and chronic infections. The strong capacity of P. aeruginosa to form biofilms can dramatically increase its antibiotic resistance and lead to tre
Externí odkaz:
https://doaj.org/article/6ee4ed4ba1924e0ab2718a6f0bffe182