Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment.

Autor: O'Connell BC; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA brendaoconnell5@gmail.com., Hubbard C; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA., Zizlsperger N; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA., Fitzgerald D; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA., Kutok JL; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA., Varner J; University of California San Diego, La Jolla, California, USA., Ilaria R Jr; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA., Cobleigh MA; Rush University Medical Center, Chicago, Illinois, USA., Juric D; Massachusetts General Hospital, Boston, Massachusetts, USA., Tkaczuk KHR; University of Maryland School of Medicine, Baltimore, Maryland, USA., Elias A; University of Colorado School of Medicine, Aurora, Colorado, USA., Lee A; UT Health East Texas, Tyler, Texas, USA., Dakhil S; Cancer Center of Kansas, Wichita, Kansas, USA., Hamilton E; Sarah Cannon Research Institute, Nashville, Tennessee, USA., Soliman H; Moffitt Cancer Center, Tampa, Florida, USA., Peluso S; Infinity Pharmaceuticals, Cambridge, Massachusetts, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Aug 30; Vol. 12 (8). Date of Electronic Publication: 2024 Aug 30.

In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy.

Autor: Ou W; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Stewart S; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., White A; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Kwizera EA; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Xu J; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Fang Y; Department of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Shamul JG; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Xie C; Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Nurudeen S; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA., Tirada NP; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA., Lu X; Department of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Tkaczuk KHR; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA., He X; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA. shawnhe@umd.edu.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA. shawnhe@umd.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 24; Vol. 14 (1), pp. 392. Date of Electronic Publication: 2023 Jan 24.

Greatly Enhanced CTC Culture Enabled by Capturing CTC Heterogeneity Using a PEGylated PDMS-Titanium-Gold Electromicrofluidic Device with Glutathione-Controlled Gentle Cell Release.

Autor: Kwizera EA; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States., Ou W; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States., Lee S; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States., Stewart S; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States., Shamul JG; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States., Xu J; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States., Tait N; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Maryland 21201, United States., Tkaczuk KHR; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Maryland 21201, United States., He X; Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Maryland 21201, United States.

Publikováno v: ACS nano [ACS Nano] 2022 Jul 26; Vol. 16 (7), pp. 11374-11391. Date of Electronic Publication: 2022 Jul 07.

Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting of TP53 Deficiency in Colon and Rectal Cancers.

Autor: Xu J; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA., Liu Y; Department of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Disease Proteomics of Zhejiang Province, Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, Research Center for Air Pollution and Health, Zhejiang University School of Medicine, Hangzhou, China.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA., Liu S; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA., Ou W; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA., White A; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA., Stewart S; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA., Tkaczuk KHR; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201, USA., Ellis LM; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA., Wan J; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA., Lu X; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA., He X; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201, USA.

Publikováno v: Nano today [Nano Today] 2022 Apr; Vol. 43. Date of Electronic Publication: 2022 Feb 01.

An Unusual Cause of a Pathological Vertebral Fracture: Solitary Plasmacytoma.

Autor: Li A; Division of General Internal Medicine, Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland., Sanchez-Petitto G; Division of Hematology/Oncology, Department of Medicine, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland. Electronic address: gabriela.sanchez@umm.edu., Tkaczuk KHR; Division of Hematology/Oncology, Department of Medicine, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland., Nageshwar M; Department of Pathology, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland., Singh Z; Department of Pathology, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland., Kocoglu M; Division of Hematology/Oncology, Department of Medicine, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland; Division of Blood and Marrow Transplant Program, Department of Medicine, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.

Publikováno v: The American journal of the medical sciences [Am J Med Sci] 2020 Aug; Vol. 360 (2), pp. 206-207. Date of Electronic Publication: 2020 Apr 11.