Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Tkačik, Gǎsper"'
Autor:
Brückner, David B., Tkačik, Gašper
A key feature of many developmental systems is their ability to self-organize spatial patterns of functionally distinct cell fates. To ensure proper biological function, such patterns must be established reproducibly, by controlling and even harnessi
Externí odkaz:
http://arxiv.org/abs/2312.05895
Many biological systems approach physical limits to their performance, motivating the idea that their behavior and underlying mechanisms could be determined by such optimality. Nevertheless, optimization as a predictive principle has only been applie
Externí odkaz:
http://arxiv.org/abs/2302.05680
Publikováno v:
Phys. Rev. X 13 (2023) 041017
Most natural and engineered information-processing systems transmit information via signals that vary in time. Computing the information transmission rate or the information encoded in the temporal characteristics of these signals, requires the mutua
Externí odkaz:
http://arxiv.org/abs/2203.03461
Autor:
Kavčič, Bor, Tkačik, Gašper
We consider a totally asymmetric simple exclusion process (TASEP) consisting of particles on a lattice that require binding by a "token" to move. Using a combination of theory and simulations, we address the following questions: (i) How token binding
Externí odkaz:
http://arxiv.org/abs/2112.13558
Models of transcriptional regulation that assume equilibrium binding of transcription factors have been very successful at predicting gene expression from sequence in bacteria. However, analogous equilibrium models do not perform as well in eukaryote
Externí odkaz:
http://arxiv.org/abs/2110.06214
Neurons in the brain are wired into adaptive networks that exhibit a range of collective dynamics. Oscillations, for example, are paradigmatic synchronous patterns of neural activity with a defined temporal scale. Neuronal avalanches, in contrast, ar
Externí odkaz:
http://arxiv.org/abs/2108.06686
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There is increasing evidence that protein binding to specific sites along DNA can activate the reading out of genetic information without coming into direct physical contact with the gene. There also is evidence that these distant but interacting sit
Externí odkaz:
http://arxiv.org/abs/1912.08579
Across diverse biological systems -- ranging from neural networks to intracellular signaling and genetic regulatory networks -- the information about changes in the environment is frequently encoded in the full temporal dynamics of the network nodes.
Externí odkaz:
http://arxiv.org/abs/1812.11884
We derive a tight lower bound on equivocation (conditional entropy), or equivalently a tight upper bound on mutual information between a signal variable and channel outputs. The bound is in terms of the joint distribution of the signals and maximum a
Externí odkaz:
http://arxiv.org/abs/1812.01475