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Fibulin-1c regulates transforming growth factor–β activation in pulmonary tissue fibrosis

Autor: Liu, G, Cooley, MA, Jarnicki, AG, Borghuis, T, Nair, PM, Tjin, G, Hsu, AC, Haw, TJ, Fricker, M, Harrison, CL, Jones, B, Hansbro, NG, Wark, PA, Horvat, JC, Scott Argraves, W, Oliver, BG, Knight, DA, Burgess, JK, Hansbro, PM

Copyright: © 2019, American Society for Clinical Investigation. Tissue remodeling/fibrosis is a major feature of all fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). It is underpinned by accumulating extracellular matrix (ECM) prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::362506b0d155b11be4ee584aa9ef0a1a
https://hdl.handle.net/10453/137003

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Retinoic acid receptor γ activity in mesenchymal stem cells regulates endochondral bone, angiogenesis, and B lymphopoiesis

Autor: Green, A.C., Rudolph-Stringer, V., Straszkowski, L., Tjin, G., Crimeen-Irwin, B., Walia, M., Martin, T.J., Sims, N.A., Purton, L.E.

Retinoic acid receptor (RAR) signaling regulates bone structure and hematopoiesis through intrinsic and extrinsic mechanisms. This study aimed to establish how early in the osteoblast lineage loss of RARγ (Rarg) disrupts the bone marrow microenviron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3c3dc54ddbe4c2bdbc3733adbaded3a2
https://eprints.whiterose.ac.uk/141821/8/Green_et_al_2018_JBMR_accepted.pdf

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Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: A novel role for CCL20 in chronic mucus hypersecretion

Autor: Faiz, A, Weckmann, M, Tasena, H, Vermeulen, CJ, Van Den Berge, M, Ten Hacken, NHT, Halayko, AJ, Ward, JPT, Lee, TH, Tjin, G, Black, JL, Haghi, M, Xu, CJ, King, GG, Farah, CS, Oliver, BG, Heijink, IH, Burgess, JK

© ERS 2018. Chronic mucus hypersecretion (CMH) contributes to the morbidity and mortality of asthma, and remains uncontrolled by current therapies in the subset of patients with severe, steroidresistant disease. Altered cross-talk between airway epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::fe63120dc46bf4714fb633f140aa88ed
https://hdl.handle.net/10453/132427

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Lysyl Oxidases: Cause Of Collagen I Matrix Remodelling In Idiopathic Pulmonary Fibrosis?

Autor: Tjin, G., Jegathees, T., Mahar, A., Pw Kable, E., K Burgess, J.

Publikováno v: Respirology, 20(2). Wiley

Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a623f8bf5654f370c597f2e41b41192d
https://research.rug.nl/en/publications/d254df24-d657-4eca-8d0f-1f6ff5341dbf

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Fibrillar collagen I matrix remodelling in idiopathic pulmonary fibrosis: Are lysyl oxidases responsible?

Autor: Tjin, G., Jegathees, T., Mahar, A., Kable, E.P.W., Burgess, J.K.

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 191. AMER THORACIC SOC

Rationale: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5a8bf8255c84d226aec8e4c2e4edd479
https://research.rug.nl/en/publications/9a1b8e7e-dbe4-450c-aced-32833f60fdab

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