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In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques

Autor: McElrath M Juliana, Ohlen Claes, Cao Jianhong, Vazquez Julio, McDonald David, Diem Kurt, Laing Kerry, Zhu Jia, Tjernlund Annelie, Picker Louis J, Corey Lawrence

Publikováno v: Retrovirology, Vol 7, Iss 1, p 12 (2010)

Abstract Background SIV and HIV predominantly replicate in lymphoid tissue, but the study of virus specific CD8+ T cells in intact lymphoid tissue is difficult, as traditional in situ tetramer staining requires fresh tissue. Results In this report, w

Externí odkaz: https://doaj.org/article/c402d79685f042f28b2434ced9e94bc9

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A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4+ cell distribution in the human rectal mucosa

Autor: Mathias Franzén Boger, Nora Benhach, Tyra Hasselrot, Rhonda M. Brand, Lisa C. Rohan, Lin Wang, Ian McGowan, Stacey Edick, Ken Ho, Leslie Meyn, Nobuyuki Matoba, Kenneth E. Palmer, Kristina Broliden, Annelie Tjernlund

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract To reduce HIV transmission, locally applied pre-exposure prophylaxis (PrEP) products for anorectal use will be important complements to oral and injectable PrEP products already available. It is critical to preserve an intact rectal epitheli

Externí odkaz: https://doaj.org/article/0e11c6efa23242c38ea13d88cf421d09

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Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers

Autor: Gabriella Edfeldt, Vilde Kaldhusdal, Paulo Czarnewski, Frideborg Bradley, Sofia Bergström, Julie Lajoie, Jiawu Xu, Anna Månberg, Joshua Kimani, Julius Oyugi, Peter Nilsson, Annelie Tjernlund, Keith R. Fowke, Douglas S. Kwon, Kristina Broliden

Publikováno v: Microbiome, Vol 11, Iss 1, Pp 1-22 (2023)

Abstract Background The majority of studies characterizing female genital tract microbiota have focused on luminal organisms, while the presence and impact of tissue-adherent ectocervical microbiota remain incompletely understood. Studies of luminal

Externí odkaz: https://doaj.org/article/dff8081e1741453d9de5744b71287711

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