Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Tjasso Blokzijl"'
Autor:
Guido Trentadue, Peter B. F. Mensink, Claudius Kruse, Bernward Reszel, Gursah Kats-Ugurlu, Tjasso Blokzijl, Jan Willem Haveman, Klaas Nico Faber, Gerard Dijkstra, Uvo M. Hölscher, Jeroen J. Kolkman, Gisbert Knichwitz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Intestinal preservation for transplantation is accompanied by hypoperfusion with long periods of ischemia with total blood cessation and absolute withdrawal of oxygen leading to structural damage. The application of intraluminal oxygen has b
Externí odkaz:
https://doaj.org/article/7738e6d875c24531bc39ed70faf54d08
Autor:
Raphael R. Fagundes, Arno R. Bourgonje, Shixian Hu, Ruggero Barbieri, Bernadien H. Jansen, Nienke Sinnema, Tjasso Blokzijl, Cormac T. Taylor, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-
Externí odkaz:
https://doaj.org/article/e4a7a598a9e746c48a15192845949bc6
Autor:
Shixian Hu, Werna T. Uniken Venema, Harm-Jan Westra, Arnau Vich Vila, Ruggero Barbieri, Michiel D. Voskuil, Tjasso Blokzijl, Bernadien H. Jansen, Yanni Li, Mark J. Daly, Ramnik J. Xavier, Gerard Dijkstra, Eleonora A. Festen, Rinse K. Weersma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Inflammatory bowel diseases are heterogeneous, and little is known about how underlying genetic variation can affect their development. Here, the authors report that intestinal inflammation modulates the effect of host genetics on the gut mucosal exp
Externí odkaz:
https://doaj.org/article/02cc8b0b815a4d49ba031137f6cb44b3
Autor:
Glauben Landskron, Karen Dubois-Camacho, Octavio Orellana-Serradell, Marjorie De la Fuente, Daniela Parada-Venegas, Mirit Bitrán, David Diaz-Jimenez, Shuang Tang, John A. Cidlowski, Xiaoling Li, Hector Molina, Carlos M. Gonzalez, Daniela Simian, Jaime Lubascher, Victor Pola, Martín Montecino, Tjasso Blokzijl, Klaas Nico Faber, María-Julieta González, Rodrigo Quera, Marcela A. Hermoso
Publikováno v:
Cells, Vol 11, Iss 12, p 1905 (2022)
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) and can be treated with glucocorticoids (GC), although some patients are unresponsive to this therapy. The transcription factor LRH-1/NR5A2 is critical to intestinal cortisol production (
Externí odkaz:
https://doaj.org/article/d47d987ba5b84968b4c265337403c29a
Autor:
Raphael R. Fagundes, Arno R. Bourgonje, Ali Saeed, Arnau Vich Vila, Niels Plomp, Tjasso Blokzijl, Mehdi Sadaghian Sadabad, Julius Z. H. von Martels, Sander S. van Leeuwen, Rinse K. Weersma, Gerard Dijkstra, Hermie J. M. Harmsen, Klaas Nico Faber
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Many chronic diseases are associated with decreased abundance of the gut commensal Faecalibacterium prausnitzii. This strict anaerobe can grow on dietary fibers, e.g., prebiotics, and produce high levels of butyrate, often associated to epithelial me
Externí odkaz:
https://doaj.org/article/9b241095487e4d15a87bb02ea127b11a
Autor:
Wouter Tobias van Haaften, Tjasso Blokzijl, Hendrik Sijbrand Hofker, Peter Olinga, Gerard Dijkstra, Ruud A. Bank, Miriam Boersema
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 13 (2020)
Background and Aims: Crohn’s disease (CD) can be complicated by intestinal fibrosis. Pharmacological therapies against intestinal fibrosis are not available. The aim of this study was to determine whether pathways involved in collagen metabolism ar
Externí odkaz:
https://doaj.org/article/9e48b0b11a31439f91188307e7e9da02
Autor:
Arno R. Bourgonje, Julius Z. H. von Martels, Ruben Y. Gabriëls, Tjasso Blokzijl, Manon Buist-Homan, Janette Heegsma, Bernadien H. Jansen, Hendrik M. van Dullemen, Eleonora A. M. Festen, Rinze W. F. ter Steege, Marijn C. Visschedijk, Rinse K. Weersma, Paul de Vos, Klaas Nico Faber, Gerard Dijkstra
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Introduction: Blood C-reactive protein (CRP) and fecal calprotectin levels are routinely measured as surrogate markers of disease activity in Inflammatory Bowel Disease (IBD), but often do not correlate well with the degree of mucosal inflammation in
Externí odkaz:
https://doaj.org/article/1d1cd076e6874f9da502d2e2b1e1d725
Autor:
Yingying Cui, Mengfan Zhang, Changsen Leng, Tjasso Blokzijl, Bernadien H. Jansen, Gerard Dijkstra, Klaas Nico Faber
Publikováno v:
Cells, Vol 9, Iss 3, p 775 (2020)
Intestinal fibrosis is a common complication of inflammatory bowel disease. So far, there is no safe and effective drug for intestinal fibrosis. Pirfenidone is an anti-fibrotic compound available for the treatment of idiopathic pulmonary fibrosis. He
Externí odkaz:
https://doaj.org/article/d983ab2fc12a4eac84309b0454094c11
Autor:
Johan H. Gibcus, Lu Ping Tan, Geert Harms, Rikst Nynke Schakel, Debora de Jong, Tjasso Blokzijl, Peter Möller, Sibrand Poppema, Bart-Jan Kroesen, Anke van den Berg
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 2, Pp 167-176 (2009)
Hodgkin lymphoma (HL) is derived from preapoptotic germinal center B cells, although a general loss of B cell phenotype is noted. Using quantitative reverse transcription-polymerase chain reaction and miRNA microarray, we determined the microRNA (miR
Externí odkaz:
https://doaj.org/article/c1d5025df3664814949176359e8b1f87
Autor:
Frank M. Raaphorst, Chris J.L.M. Meijer, Elly Fieret, Tjasso Blokzijl, Ellen Mommers, Horst Buerger, Jens Packeisen, Richard A.B. Sewalt, Arie P. Ottet, Paul J. van Diest
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 6, Pp 481-488 (2003)
Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis. We describe the expression of five PcG genes (BMI-1, RING1, HPC1, HPC2, and EZH2) in normal breast tissues, invasive breast carcinomas,
Externí odkaz:
https://doaj.org/article/d9fc1fe039f14b71b6db7d5c914b04b0