Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Tiziano, Tuccinardi"'
Autor:
Simona Mattioli, Filippo Fratini, Chiara Cacchiarelli, Valentina Martinis, Tiziano Tuccinardi, Gisella Paci, Alessandro Dal Bosco, Simone Mancini
Publikováno v:
Italian Journal of Animal Science, Vol 23, Iss 1, Pp 125-137 (2024)
In the last decade, great attention was placed on insects to increase feed-food production without negatively affecting the environment. In this research study we compare three different insect species (Alphitobius diaperinus, Tenebrio molitor, and Z
Externí odkaz:
https://doaj.org/article/2c90f4e4c7574d519512f5e38ca4f98c
Autor:
Hannah Åbacka, Samuele Masoni, Giulio Poli, Peng Huang, Francesco Gusso, Carlotta Granchi, Filippo Minutolo, Tiziano Tuccinardi, Anna K. Hagström-Andersson, Karin Lindkvist-Petersson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common among children. AML is characterized by aberrant proliferation of myeloid blasts in the bone marrow and impaired normal hematopoiesis
Externí odkaz:
https://doaj.org/article/ea900aef07be4cb98d6a67af45956451
Autor:
Miriana Di Stefano, Salvatore Galati, Lisa Piazza, Francesca Gado, Carlotta Granchi, Marco Macchia, Antonio Giordano, Tiziano Tuccinardi, Giulio Poli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
We present a new computational approach, named Watermelon, designed for the development of pharmacophore models based on receptor structures. The methodology involves the sampling of potential hotspots for ligand interactions within a protein target
Externí odkaz:
https://doaj.org/article/3961fed658e1472d8c4b064e407e4d66
Autor:
Giulio Poli, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
hRPE65 is a fundamental enzyme of the retinoid visual cycle, and many missense mutations affecting its expression or function are associated with a wide range of diseases. Many hRPE65 missense mutations lack a clear pathogenicity classification or ar
Externí odkaz:
https://doaj.org/article/7c89f3b7f8fb4854b84bd0e0b60daf9f
Publikováno v:
Molecules, Vol 29, Iss 9, p 1930 (2024)
The phenyl(piperidin-4-yl)methanone fragment (here referred to as the benzoylpiperidine fragment) is a privileged structure in the development of new drugs considering its presence in many bioactive small molecules with both therapeutic (such as anti
Externí odkaz:
https://doaj.org/article/6816455dde564c90b93b21d9b672a53a
Autor:
Simone Mancini, Filippo Fratini, Isabella Provera, Jessica Dovicchi, Tiziano Tuccinardi, Sara Minieri, Roberto Amerigo Papini, Mario Forzan, Gisella Paci
Publikováno v:
Italian Journal of Animal Science, Vol 21, Iss 1, Pp 1419-1429 (2022)
Tenebrio molitor (mealworm) larvae are one of the most intriguing edible insects, and they may be raised on a variety of substrates, including by-products, side-stream products, and former foodstuff. The substrates could affect drastically the produc
Externí odkaz:
https://doaj.org/article/78d1c524918e40b686a7241f55f22642
Autor:
Giulio Poli, Ivana Barravecchia, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1765-1772 (2022)
The human retinal pigment epithelium-specific 65-kDa protein (hRPE65) plays a crucial role within the retinoid visual cycle and several mutations affecting either its expression level or its enzymatic function are associated with inherited retinal di
Externí odkaz:
https://doaj.org/article/32ce20e5e4674bca8efb26b1a3d728b6
Autor:
Salvatore Galati, Miriana Di Stefano, Simone Bertini, Carlotta Granchi, Antonio Giordano, Francesca Gado, Marco Macchia, Tiziano Tuccinardi, Giulio Poli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17233 (2023)
Glycogen synthase kinase-3 beta (GSK3β) is a serine/threonine kinase that plays key roles in glycogen metabolism, Wnt/β-catenin signaling cascade, synaptic modulation, and multiple autophagy-related signaling pathways. GSK3β is an attractive targe
Externí odkaz:
https://doaj.org/article/cf65f0311c554eb48d63112e232e2afa
Autor:
Emanuela Berrino, Simone Carradori, Fabrizio Carta, Francesco Melfi, Marialucia Gallorini, Giulio Poli, Tiziano Tuccinardi, José G. Fernández-Bolaños, Óscar López, Jacobus P. Petzer, Anél Petzer, Paolo Guglielmi, Daniela Secci, Claudiu T. Supuran
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2044 (2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial etiology. The most common NDs are Alzheimer’s disease and Parkinson’s disease, in which cholinergic and dopaminergic sys
Externí odkaz:
https://doaj.org/article/b5a1744f71ab47be8afc72bbec67ca7a
Autor:
Giulio Poli, Miriana Di Stefano, Joan Arias Estevez, Filippo Minutolo, Carlotta Granchi, Antonio Giordano, Salvatore Parisi, Matteo Mauceri, Vincenzo Canzonieri, Marco Macchia, Isabella Caligiuri, Tiziano Tuccinardi, Flavio Rizzolio
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 145-150 (2022)
PIN1 is considered as a therapeutic target for a wide variety of tumours. However, most of known inhibitors are devoid of cellular activity despite their good enzyme inhibitory profile. Hence, the lack of effective compounds for the clinic makes the
Externí odkaz:
https://doaj.org/article/cf62bc6b195e4bc6b05154bb0957ad8b