Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tiziana Spatola"'
Autor:
Sophie Doublier, Cristina Zennaro, Luca Musante, Tiziana Spatola, Giovanni Candiano, Maurizio Bruschi, Luca Besso, Massimo Cedrino, Michele Carraro, Gian Marco Ghiggeri, Giovanni Camussi, Enrico Lupia
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188045 (2017)
CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells. We describe here a novel role for soluble CD40L (s
Externí odkaz:
https://doaj.org/article/0fe5eca252594ac48f9c7b55507ae122
Autor:
Alessandra Cuccurullo, Elisabetta Greco, Enrico Lupia, Paolo De Giuli, Ornella Bosco, Erica Martin-Conte, Tiziana Spatola, Emilia Turco, Giuseppe Montrucchio
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151088 (2016)
BACKGROUND AND PURPOSE:Thrombopoietin (TPO), a growth factor primarily involved in thrombopoiesis may also have a role in the pathophysiology of sepsis. In patients with sepsis, indeed, TPO levels are markedly increased, with disease severity being t
Externí odkaz:
https://doaj.org/article/91daf66c1f5d4878975e80b285b266d2
Autor:
Enrico Derenzini, Alberto Bosi, Marco Ruella, Anna Paola Iori, Tiziana Spatola, Giuseppe Milone, Alessandro Rambaldi, Alessandra Risso, Stella Santarone, Pietro Pioltelli, Andrea Bacigalupo, William Arcese, Corrado Tarella
Physiologic loss of telomerase activity in adult life determines progressive telomere length (TL) shortening. Inflammation and oxidative damage are established causes of TL loss; moreover, males have shorter telomeres compared with females. Despite t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3b0aa9f9d31d63eeeebe14046c6640
http://hdl.handle.net/2108/212184
http://hdl.handle.net/2108/212184
Autor:
Cristina Zennaro, Giovanni Candiano, Maurizio Bruschi, Enrico Lupia, Massimo Cedrino, Tiziana Spatola, Gian Marco Ghiggeri, Luca Besso, Michele Carraro, Giovanni Camussi, Luca Musante, Sophie Doublier
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188045 (2017)
PLoS ONE, Vol 12, Iss 11, p e0188045 (2017)
CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells. We describe here a novel role for soluble CD40L (s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68092c7b7c225887326006c2d749f0c3
https://hdl.handle.net/11567/1104020
https://hdl.handle.net/11567/1104020
Autor:
Corrado Tarella, Alessandra Risso, Tiziana Spatola, Stefano Buttiglieri, Lorenzo Silengo, Marco Ruella, Enrico Vittorio Avvedimento
Publikováno v:
Experimental Hematology. 39:1171-1181
Various agents, including chemotherapeutic drugs, can induce cell senescence. However, the mechanisms involved in the aging pathway, particularly the stress that chemotherapy imposes on telomeres, are still undefined. To address these issues, human m
Autor:
Alberto Goffi, Cesare Poletto, Giuseppe Montrucchio, Tiziana Spatola, Enrico Lupia, Stefania Locatelli, Alessandra Cuccurullo, Ornella Bosco
Publikováno v:
Atherosclerosis. 210:314-319
Objectives : Thrombopoietin (TPO) is a humoral growth factor that primes platelet activation in response to several agonists. We recently showed that TPO enhances platelet activation in unstable angina and sepsis. Aim of this study was to investigate
Autor:
Francesco Di Carlo, Tiziana Spatola, Giovanni Camussi, Benedetta Bussolati, Maria Chiara Deregibus, Simone Procida, Sophie Doublier, Valentina Fonsato
Publikováno v:
Journal of the American Society of Nephrology. 16:1936-1947
The injury of podocytes is associated with alterations of the glomerular size-selective barrier to proteins. In this study, oxidized LDL (oxLDL) but not native LDL induced apoptosis in human cultured podocytes and reduced Akt activity and P-Akt/Akt r
Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis
Autor:
Tiziana Spatola, Alessandra Cuccurullo, Erica L. Martin-Conte, Paolo De Giuli, Emilia Turco, Ornella Bosco, Elisabetta Greco, Giuseppe Montrucchio, Enrico Lupia
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0151088 (2016)
PLoS ONE, Vol 11, Iss 3, p e0151088 (2016)
BACKGROUND AND PURPOSE:Thrombopoietin (TPO), a growth factor primarily involved in thrombopoiesis may also have a role in the pathophysiology of sepsis. In patients with sepsis, indeed, TPO levels are markedly increased, with disease severity being t
Autor:
Alessandra Risso, Stefano Buttiglieri, Alessandra Carobbio, Silvia Salmoiraghi, Tiziana Spatola, Alessandro Rambaldi, Piera Sivera, Irene Ricca, Corrado Tarella, Tiziano Barbui, Marco Ruella
Publikováno v:
Experimental hematology. 41(7)
The purpose of this study was to investigate telomere length (TL) in Ph-negative chronic myeloproliferative neoplasms (Ph-neg-CMNs), and the possible association of TL with disease progression and hydroxycarbamide (HU) treatment. TL was analyzed in p
Autor:
Enrico Lupia, Filippo Mariano, Alessandra Cuccurullo, Giuseppe Alloatti, Angela Pucci, Tiziana Spatola, Roberta Ramella, Giuseppe Montrucchio, Ornella Bosco
Publikováno v:
Basic research in cardiology. 105(5)
Thrombopoietin (TPO) is a humoral growth factor that has been shown to increase platelet activation in response to several agonists. Patients with sepsis have increased circulating TPO levels, which may enhance platelet activation, potentially partic