Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tiziana Masini"'
Autor:
Alberto Matteelli, Gavin Churchyard, Daniela Cirillo, Saskia den Boon, Dennis Falzon, Yohhei Hamada, Rein M G J Houben, Avinash Kanchar, Afrânio Kritski, Blessina Kumar, Cecily Miller, Dick Menzies, Tiziana Masini
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 7, p e0003306 (2024)
The provision of tuberculosis preventive treatment is one of the critical interventions to reduce tuberculosis incidence and ultimately eliminate the disease, yet we still miss appropriate tools for an impactful intervention and treatment coverage re
Externí odkaz:
https://doaj.org/article/b5089e26658d4fd8adbc70bcfe7b50fc
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Autor:
Roeland E. Wasmann, Tiziana Masini, Kerri Viney, Sabine Verkuijl, Annemieke Brands, Anneke C. Hesseling, Helen McIlleron, Paolo Denti, Kelly E. Dooley
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Following infection with Mycobacterium tuberculosis, young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the Wo
Externí odkaz:
https://doaj.org/article/7d5f5eb528d14b1ea543e2e421c070cb
Autor:
Niccolò Riccardi, Sara Occhineri, Elisa Vanino, Roberta Maria Antonello, Agostina Pontarelli, Francesca Saluzzo, Tiziana Masini, Giorgio Besozzi, Marina Tadolini, Luigi Codecasa, on behalf of StopTB Italia
Publikováno v:
Antibiotics, Vol 12, Iss 12, p 1733 (2023)
Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide and pulmonary TB (PTB) is the main variant responsible for fueling transmission of the infection. Effective treatment of drug-susceptible (DS) TB is crucial to a
Externí odkaz:
https://doaj.org/article/61777a83b2c74354b0ac4317dd3f660e
Autor:
Jennifer Walsh, Tiziana Masini, Benedikt D. Huttner, Lorenzo Moja, Martina Penazzato, Bernadette Cappello
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 473 (2022)
The World Health Organization’s Model List of Essential Medicines for Children (EMLc) presents a list of the most efficacious, safe, and cost-effective medicines for priority conditions, intended for use in children up to 12 years of age. However,
Externí odkaz:
https://doaj.org/article/54e0327f968f48f7aef5151fb9857c47
Publikováno v:
Indian Journal of Medical Research. 157:220-222
Autor:
Alexander W Kay, Tara Ness, Sabine E Verkuijl, Kerri Viney, Annemieke Brands, Tiziana Masini, Lucia González Fernández, Michael Eisenhut, Anne K Detjen, Anna M Mandalakas, Karen R Steingart, Yemisi Takwoingi
Publikováno v:
The Cochrane Database of Systematic Reviews
Background Every year, at least one million children become ill with tuberculosis and around 200,000 children die. Xpert MTB/RIF and Xpert Ultra are World Health Organization (WHO)‐recommended rapid molecular tests that simultaneously detect tuberc
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Christopher Milne, Andrea Cavalli, Josef Wachtveitl, Michel Steinmetz, Jörg Standfuss
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a72c6a2aafb8c867ef93395e8b9fb46
https://doi.org/10.21203/rs.3.rs-1964458/v1
https://doi.org/10.21203/rs.3.rs-1964458/v1
Autor:
Di Zhu, Sandra Johannsen, Tiziana Masini, Céline Simonin, Jörg Haupenthal, Boris Illarionov, Anastasia Andreas, Mahendra Awale, Robin M. Gierse, Tridia van der Laan, Ramon van der Vlag, Rita Nasti, Mael Poizat, Eric Buhler, Norbert Reiling, Rolf Müller, Markus Fischer, Jean-Louis Reymond, Anna K. H. Hirsch
Publikováno v:
Chemical Science, 13(36), 10686-10698. ROYAL SOC CHEMISTRY
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g
In the present manuscript, we describe how we successfully used ligand-based virtual screening (LBVS) to identify two small-molecule, drug-like hit classes with excellent ADMET profiles against the difficult to address microbial enzyme 1-deoxy-D-xylu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d037a73a79e9b4607948d4bb961dcdb1
https://research.rug.nl/en/publications/47d91e4b-c3e0-48f1-b774-6f2c690412a0
https://research.rug.nl/en/publications/47d91e4b-c3e0-48f1-b774-6f2c690412a0
Autor:
Tiziana Masini, Avinash Kanchar, Fuad Mirzayev, Kerri Viney, Askar Yedilbayev, Matteo Zignol, Dennis Falzon
Publikováno v:
The European respiratory journal. 60(2)